Registered Reports: Peer review before results are known to align scientific values and practices.

Registered Reports is a publishing format used by over 250 journals that emphasizes the importance of the research question and the quality of methodology by conducting peer review prior to data collection. High quality protocols are then provisionally accepted for publication if the authors follow through with the registered methodology.

This format is designed to reward best practices in adhering to the hypothetico-deductive model of the scientific method. It eliminates a variety of questionable research practices, including low statistical power, selective reporting of results, and publication bias, while allowing complete flexibility to report serendipitous findings.

This page includes information on Registered Reports including readings on Registered Reports, Participating Journals, Details & Workflow, Resources for Editors, Resources For Funders, FAQs, and Allied Initiatives.

The University of California, Irvine Extension, supported by generous grants from the William and Flora Hewlett Foundation and The Boeing Company, is developing online courses to prepare science and mathematics teachers for the California Subject Examinations for Teachers (CSET).

UC Irvine Extension's online test-preparation courses correspond with the 10 CSET science subtests and three CSET mathematics subtests.

Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students (2021) is an undergraduate medical-level resource for foundational knowledge across the disciplines of genetics, cell biology and biochemistry. This USMLE-aligned text is designed for a first-year undergraduate medical course that is delivered typically before students start to explore systems physiology and pathophysiology. The text is meant to provide the essential information from these content areas in a concise format that would allow learner preparation to engage in an active classroom. Clinical correlates and additional application of content is intended to be provided in the classroom experience. The text assumes that the students will have completed medical school prerequisites (including the MCAT) in which they will have been introduced to the most fundamental concepts of biology and chemistry that are essential to understand the content presented here. This resource should be assistive to the learner later in medical school and for exam preparation given the material is presented in a succinct manner, with a focus on high-yield concepts.

The 276-page text was created specifically for use by pre-clinical students at Virginia Tech Carilion School of Medicine and was based on faculty experience and peer review to guide development and hone important topics.

Available Formats
978-1-949373-42-4 (PDF)
978-1-949373-43-1 (ePub) [coming soon]
978-1-949373-41-7 (Pressbooks) https://pressbooks.lib.vt.edu/cellbio
Also available via LibreTexts: https://med.libretexts.org/@go/page/37584

How to Adopt this Book
Instructors reviewing, adopting, or adapting parts or the whole of the text are requested to register their interest at: https://bit.ly/interest-preclinical.

Instructors and subject matter experts interested in and sharing their original course materials relevant to pre-clinical education are requested to join the instructor portal at https://www.oercommons.org/groups/pre-clinical-resources/10133.

Features of this Book
1. Detailed learning objectives are provided at the beginning of each subsection
2. High resolution, color contrasting figures illustrate concepts, relationships, and processes throughout
3. Summary tables display detailed information
4. End of chapter lists provide additional sources of information
5. Accessibility features including structured heads and alternative-text provide access for readers accessing the work via a screen-reader

Table of Contents
1. Biochemistry basics
2. Basic laboratory measurements
3. Fed and fasted state
4. Fuel for now
5. Fuel for later
6. Lipoprotein metabolism and cholesterol synthesis
7. Pentose phosphate pathway (PPP), purine and pyrimidine metabolism
8. Amino acid metabolism and heritable disorders of degradation
9. Disorders of monosaccharide metabolism and other metabolic conditions
10. Genes, genomes, and DNA
11. Transcription and translation
12. Gene regulation and the cell cycle
13. Human genetics
14. Linkage studies, pedigrees, and population genetics
15. Cellular signaling
16. Plasma membrane
17. Cytoplasmic membranes
18. Cytoskeleton
19. Extracellular matrix

Suggested Citation
LeClair, Renée J., (2021). Cell Biology, Genetics, and Biochemistry for Pre-Clinical Students, Blacksburg, VA: Virginia Tech Publishing. https://doi.org/10.21061/cellbio. Licensed with CC BY NC-SA 4.0.

About the Author
Renée J. LeClair is an Associate Professor in the Department of Basic Science Education at the Virginia Tech Carilion School of Medicine, where her role is to engage activities that support the departmental mission of developing an integrated medical experience using evidence-based delivery grounded in the science of learning. She received a Ph.D. at Rice University and completed a postdoctoral fellowship at the Maine Medical Center Research Institute in vascular biology. She became involved in medical education, curricular renovation, and implementation of innovative teaching methods during her first faculty appointment, at the University of New England, College of Osteopathic Medicine. In 2013, she moved to a new medical school, University of South Carolina, School of Medicine, Greenville. The opportunities afforded by joining a new program and serving as the Chair of the Curriculum committee provided a blank slate for creative curricular development and close involvement with the accreditation process. During her tenure she developed and directed a team-taught student-centered undergraduate medical course that integrated the scientific and clinical sciences to assess all six-core competencies of medical education.

Accessibility Note
The University Libraries at Virginia Tech and Virginia Tech Publishing are committed to making its publications accessible in accordance with the Americans with Disabilities Act of 1990. The HTML (Pressbooks) and ePub versions of this book utilize header structures and include alternative text which allow for machine-readability.

Please report any errors at https://bit.ly/feedback-preclinical

This textbook was written for collegiate Cell and Molecular Biology courses and may be appropriate at both an introductory level and also as a resource for more advanced courses.

Short Description:
Proteins play vital roles in most biological processes; these roles include acting as catalysts for physiological reactions, as regulators for those reactions, or as structural framework around which these processes can occur. Proteins’ complex organization of diverse functionality in 3D space leads to an astonishing range of function for living organisms. Understanding this intimate relationship between structure and function is the backbone of understanding the natural world and is the key to controlling it. Data dashboard

Word Count: 13793

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

A mini series of choose your own adventure cases for students to explore blood bank workflow and decision making. Topics covered:Hemolytic Disease of the NewbornABO DiscrepancyCrossmatchingAuto Antibodies

Introduction to citations as a presentation. Citing data and code as well as getting citations for data and code.

If you'd visited Tuolumne Meadows in Yosemite National Park 100 years ago, you probably would have encountered the alpine chipmunk, Tamias alpinus. Today, however, park visitors will have to hike up a nearby mountain to see one of these critters. That's because this species is sensitive to temperature and over the last hundred years of global climate change, Yosemite has warmed by about 5.5 degrees Fahrenheit. As the temperature increased, the chipmunks retreated to higher and higher elevations where it was cooler. Today, they occupy a fraction of their original range. If climate change continues, they could be squeezed right off the tops of their mountains and out of existence.

Concepts of Biology is designed for the introductory biology course for nonmajors taught at most two- and four-year colleges. The scope, sequence, and level of the program are designed to match typical course syllabi in the market. Concepts of Biology includes interesting applications, features a rich art program, and conveys the major themes of biology.

Short Description:
This book provides an introduction to the genetic concepts of reproductive systems, recombination, mutation, segregation and linkage analysis, inbreeding, quantitative inheritance, fertility regulation, population genetics and polyploidy.

Long Description:
This book provides an introduction to the genetic concepts of reproductive systems, recombination, mutation, segregation and linkage analysis, inbreeding, quantitative inheritance, fertility regulation, population genetics and polyploidy.

Word Count: 61452

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

This activity will help students understand how the enzyme telomerase works to solve the "end replication problem."

Course materials on using OpenRefine, a powerful tool for cleaning and transforming tabular data.

Compiled to support a course on teaching math and science in Early Childhood Education. Chapters include: Early Learning; Math & Science Connections; Theory & Teacher Effectiveness; Special Needs; Standards & Assessment; Lesson Planning; Centers & Environment; Teaching Science Content; Teaching Math Content; and Hands-on Learning.

Word Count: 74439

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Short Description:
Labs in this book supplement the information gained in lecture, as well as providing some perspective and experience with hands-on applications of ideas in pest management. The labs are presented in week-by-week order, so the pre-labs and reading for week 1 are labeled “Pre-Lab 1” and “Week 1 Reading”. Data dashboard

Word Count: 21598

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Short Description:
This college-level open textbook covers the most salient environmental issues from a biological perspective. Order a print copy: http://www.lulu.com/content/paperback-book/environmental-biology/23350620

Long Description:
This open textbook covers the most salient environmental issues, from a biological perspective. The text is designed for an introductory-level college science course. Topics include the fundamentals of ecology, biodiversity, pollution, climate change, food production, and human population growth.

Order a print copy: http://www.lulu.com/content/paperback-book/environmental-biology/23350620

Word Count: 95192

ISBN: 978-1-63635-036-3

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Swarms of tiny robots have given up their selfish ways and started sharing resources for the greater good. Though this might sound like the plot of a bad summer blockbuster, it is real news. This month, a team of Swiss researchers announced that they've used robots to simulate biological evolution. The simple, mobile robots - each a little larger than a sugar cube - began their lives directionless, meandering aimlessly into walls. But after a few generations of natural selection, their computer programs evolved so that they became efficient foragers, purposefully collecting disks that represent food. None of that is particularly surprising. Scientists have long been able to simulate evolution through computer programs that mimic the processes of genetic inheritance, mutation, recombination, and reproduction. What is noteworthy is that many of these robots eventually evolved to help one another, sacrificing personal success to aid other robots in their group.

This chapter details cell-cell communication highlighting studies performed in the model organism Dictyostelium discoideum. Topics covered include signaling molecules, cell surface receptors, and subversion of host cell signaling by pathogens.

Back in the Jurassic, dinosaurs may have dominated terrestrial ecosystems, but they were not alone. Scurrying around their feet and clinging to the trees above them were the fuzzy ancestors of their successors. When most of the dinosaurs perished, the surviving mammals diversified into the dinosaurs' niches, where they remain today. Last month, scientists reported on the discovery of a fossil mammal from China that would have lived alongside the dinosaurs and that, at 160 million years old, represents one of the earliest mammals known.