This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Healthy corneas are clear and lack blood vessels, but injuries like alkali burns can trigger neovascularization. This serious complication reduces the patient’s vision and is the leading cause of failure in corneal transplants. Previous studies have suggested that AIP1 (Apoptosis signal-regulating kinase 1-interacting protein) is involved in inflammatory neovascularization induction and that NOX4 (NADPH oxidase 4) is activated by alkali burns. NOX4 can produce reactive oxygen species (ROS) which unbalance the expression of the inflammation-related proteins NLRP3 and NLRP6 (NLR family pyrin domain containing 3 and 6). Researchers recently used a mouse model to examine how AIP1 and NOX4 are related to NLRP3/NLRP6 after corneal alkali burns. Corneal alkali burns decreased AIP1 expression and increased the expression of two pro-angiogenic proteins, clv-IL-1β (cleaved interleukin-1β) and VEGFa (vascular endothelial growth factor A)..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

AIRS is an open source set of online modules and resources in research skills and knowledge. It provides the grounding in research processes with practical tools to support you.

AIRS is a mandatory coursework requirement for Higher Degree Research (HDR) students enrolled in a Doctor of Philosophy (PhD) or Master of Philosophy (MPhil), at the Queensland University of Technology (QUT).

aiEDU's AI Toolkits are materials designed to support teachers, parents and other community champions to share the importance of artificial intelligence education and support its adoption in your learning spaces.

World Education's AI for Learning and Work initiative is dedicated to exploring the intersection of artificial intelligence and education, and how it can shape the future of the way we live and work. On this page, you can access open resources, professional development offerings and opportunities to get involved.

Garnet Valley School District in PA established a deep commitment to open education when it first joined the #GoOpen Network over eight years ago to advance an OER initiative. Still on an innovative journey to transform teaching and learning, the district’s Director of Technology and Online Learning and Founder and Executive Director of nonprofit Edvative Learning, Sam Mormando is actively exploring the rapidly evolving landscape of AI technology and reflecting on ways it may be advantageous for education, and specifically, for OER. 

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Some proteins are central to many cell signaling processes. One of these key molecules is AKT2. An important kinase involved in cell survival, growth, and metabolism, it has ties to insulin-induced signaling and cancer. AKT2 has a critical role in immune cells such as neutrophils and macrophages; however, although AKT2 is expressed in antibody-producing immune cells called B cells, its function in B cells isn’t clear. In a recent study, researchers sought to understand the role of AKT2 in B cells using AKT2-deficient mice. They found that mice lacking AKT2 had impaired B-cell differentiation. B cells from these mice were not able to form a cluster of molecules called a signalosome in response to B-cell receptor (BCR) signaling, resulting in poor BCR signaling and impaired B cell activation and spreading. These results suggest that as a central orchestrator of signaling, AKT2 function is critical for proper BCR signaling and B cell development, ensuring a functional antibody-mediated immune response..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Gq protein-coupled receptors (GqPCRs) are membrane bound proteins that transmit signals from outside the cell to internal signaling pathways. One of these pathways is the PI3K/AKT pathway, which plays roles in cellular proliferation, survival, metabolism, and differentiation. PI3K/AKT dysregulation is also often implicated in cancers. A previous study determined that activating GqPCRs in certain cells inactivated AKT, which led to a specific type of cell death, JNK-dependent apoptosis. This unique signal seems to play an important role in physiological and pathological events like pituitary development and cardiac hypertrophy. Now, a new study determined that the mechanism of this AKT inactivation relies on another signaling-related protein, PP2A. When the GqPCRs are not activated, a fraction of PP2A "c" subunit is in a dimer complex with another protein, IGBP1 and they are bound to the p85 subunit of PI3K, causing its activation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This assignment is about exploring alternative ways of sharing goods and services and understanding the benefits, drawbacks, and implications of these methods. Students are asked to choose one of seven non-market distribution methods, such as majority rule, contests, force, first-come/first-served, sharing equally, lottery, and personal characteristics, and observe how it is implemented in real-life scenarios. They need to explain the distribution method, who benefits from it, who is excluded, and the advantages and disadvantages of using it. Students also have to find a real-life example of the chosen non-market distribution method, describe how it is used, and assess its fairness and efficiency. Lastly, they are required to include a citation and ensure their submission is no less than 180 words and comprises a list of cited works. The goal of the assignment is to better understand how goods and services are distributed and how these methods affect different groups of people.

In this class, we will explore America's diversity through questions of immigration, race, gender/sexuality and class--some of the major ways our culture is organized. It is comprised of 9 lessons based on online resources, plus 2 auto-ethnography assignments. This class was originally taught by Huma Mohibullah at Renton Technical College. 

Religion is a significant aspect of human cultures everywhere. In these lessons, we explore questions such as: What are the main elements of religion? Why is believing in a higher power important to human beings across cultures? How is religion related to our social orders? How is religion related to the politics of today's world?This resource is comprised of 7 lessons based on online modules, plus a final presentation assignment. Each lesson includes a discussion or written assignment. This class was originally taught by Huma Mohibullah at Renton Technical College. 

The standard citation style guide book for the fields of business, education, health science, public service, and social science is the Publication Manual of the American Psychological Association, 6th edition, 2010. The American Psychological Association (APA) publishes the manual. We commonly refer to it as "the APA Manual".

The business, education, health science, public service, and social science departments at IRSC recommend APA format for papers written in these fields.

Two types of citations are included in most research papers: citations within the text of the document and a list of reference citations at the end of the paper.

In-Text Citations:

The APA Manual uses the author-date citation system for in-text citations.

Reference Citations:

The sources you use in your work are included as a separate list at the end of the paper. The APA Manual suggests using the title, References, for the list.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Immune checkpoints are an effective way that cancers evade the immune system, but they're not the only one. In the case of pancreatic ductal carcinoma, or PDAC, tumor fibrosis also plays an important role. To understand how fibrosis might translate to poor outcomes among patients with PDAC, researchers examined the ARF6-AMAP1 molecular pathway, which research suggests is activated during fibrosis. Findings revealed that AMAP1 correlated with elevated expression of PD-L1, a molecule that tumor cells present on their surface to elude attack by the immune system. AMAP1 was also linked to elevated fibrosis. Consistently, silencing AMAP1 in a mouse model of human PDAC reduced PD-L1 and fibrosis in their tumors. Suppressing the ARF6-AMAP1, therefore, could be one way to ensure that PDAC tumors can’t hide from immune defenses, offering the prospect of more effective immunotherapies for patients with pancreatic ductal carcinoma..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Poor research reporting is a major contributing factor to low study reproducibility, financial and animal waste. The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines were developed to improve reporting quality and many journals support these guidelines. The influence of this support is unknown. We hypothesized that papers published in journals supporting the ARRIVE guidelines would show improved reporting compared with those in non-supporting journals. In a retrospective, observational cohort study, papers from 5 ARRIVE supporting (SUPP) and 2 non-supporting (nonSUPP) journals, published before (2009) and 5 years after (2015) the ARRIVE guidelines, were selected. Adherence to the ARRIVE checklist of 20 items was independently evaluated by two reviewers and items assessed as fully, partially or not reported. Mean percentages of items reported were compared between journal types and years with an unequal variance t-test. Individual items and sub-items were compared with a chi-square test. From an initial cohort of 956, 236 papers were included: 120 from 2009 (SUPP; n = 52, nonSUPP; n = 68), 116 from 2015 (SUPP; n = 61, nonSUPP; n = 55). The percentage of fully reported items was similar between journal types in 2009 (SUPP: 55.3 ± 11.5% [SD]; nonSUPP: 51.8 ± 9.0%; p = 0.07, 95% CI of mean difference -0.3–7.3%) and 2015 (SUPP: 60.5 ± 11.2%; nonSUPP; 60.2 ± 10.0%; p = 0.89, 95%CI -3.6–4.2%). The small increase in fully reported items between years was similar for both journal types (p = 0.09, 95% CI -0.5–4.3%). No paper fully reported 100% of items on the ARRIVE checklist and measures associated with bias were poorly reported. These results suggest that journal support for the ARRIVE guidelines has not resulted in a meaningful improvement in reporting quality, contributing to ongoing waste in animal research.

In this resource, you will find important information and activities about Huilense culture. Read about it and follow the instructions to complete the activities. 

An interactive applet and associated web page that shows how triangles that have two angles and their included side the same must be congruent. The applet shows two triangles, one of which can be reshaped by dragging any vertex. The other changes to remain congruent to it and the two angles and the included side are outlined in bold to show they are the same measure and are the elements being used to prove congruence. The web page describes all this and has links to other related pages. Applet can be enlarged to full screen size for use with a classroom projector. This resource is a component of the Math Open Reference Interactive Geometry textbook project at http://www.mathopenref.com.

This is a Canvas shell populated with videos that are freely available and suggestions for their use and other resources, if available. Videos may have restrictions on their use.

This is a Canvas shell populated with videos that are freely available and suggestions for their use and other resources, if available. Videos may have restrictions on their use.