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Marathon Mouse
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Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in ...

Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse. This video is featured on the DVD Science of Fat, available free from HHMI. This video is 52 seconds in length, and available in MOV (6 MB) and WMV (8 MB). All Obesity videos are located at: http://www.hhmi.org/biointeractive/obesity/video.html

Subject:
Health, Medicine and Nursing
Anatomy/Physiology
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Measuring Circadian Activity in Drosophila
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This animation series shows four experiments that compare the activity patterns of ...

This animation series shows four experiments that compare the activity patterns of a wild-type fly keeping a normal schedule with those of a mutant fly apparently following a 19-hour internal clock.

Subject:
Health, Medicine and Nursing
Biology
Chemistry
Material Type:
Diagram/Illustration
Lecture
Reading
Simulation
Provider:
Howard Hughes Medical Institute
Meet the Geneticists
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Meet the OLogists is part of OLogy, where kids can collect virtual ...

Meet the OLogists is part of OLogy, where kids can collect virtual trading cards and create projects with them. Here, they can learn more about three kids and one scientist whose curiosity focuses on genetics: Emily, a 12-year-old from New York who is interested in her genetic ability to curl her tongue and in her cat's colorings. Logan, an 11-year-old from Washington State who has a plan for scientists interested in cloning a woolly mammoth. Seth, a 12-year-old from Kansas who got excited about genetics when he visited an agronomy farm. Rob deSalle, a molecular biologist who answers kids' questions, including "Do all species of plants and animals have the same amount of DNA?"

Subject:
Biology
Genetics
Material Type:
Reading
Provider:
American Museum of Natural History
Provider Set:
American Museum of Natural History
Microbiology in Jeopardy
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This group learning activity involves students in an engaging review of concepts ...

This group learning activity involves students in an engaging review of concepts of microbiology. The review is set up as a power point presentation in the style of the "Jeopardy" gameshow where students groups compete against each other to answer review questions.

Subject:
Education
Life Science
Chemistry
Material Type:
Activity/Lab
Provider:
Science Education Resource Center (SERC) at Carleton College
Provider Set:
Pedagogy in Action
Author:
Stephen C. Wagner, Stephen F. Austin State University
Modern Biology
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This course covers specialized and somewhat advanced topics in the fields of ...

This course covers specialized and somewhat advanced topics in the fields of cellular biology, molecular biology, biochemistry, and genetics. It does not cover organismal biology or taxonomy. The course is carefully planned to provide the background that biology students will need for advanced biology classes. Non-biology majors will also find this course useful as it explains many of the concepts and techniques currently discussed in the popular press.

This course is built around six key concepts that provide unifying explanations for how and why structures are formed and processes occur throughout your study of biology. Because it is not possible to cover the breadth of modern molecular biology in one semester, an understanding of these key concepts will provide a basis for extension of your knowledge to biological systems beyond the specifics covered in this course. One of the major goals of the course therefore is for you to not only learn the definitions of the concepts but also learn to recognize when they are operating the process being studied.

Topics covered include: Biological Chemistry, Cell Biology, Molecular biology, and Metabolism.

Subject:
Biology
Genetics
Material Type:
Assessment
Full Course
Interactive
Reading
Provider:
Carnegie Mellon University
Provider Set:
Open Learning Initiative
Molecular Biology
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After a historical introduction to molecular biology, this course describes the basic ...

After a historical introduction to molecular biology, this course describes the basic types of DNA and RNA structure and the molecular interactions that shape them. It describes how DNA is packaged within the cellular nucleus as chromosomes. It also describes the core processes of molecular biology: replication of DNA, transcription of DNA into messenger RNA, and translation of messenger RNA into a protein. These are followed by modifications of these basic processes: regulation of gene expression, DNA mutation and repair, and DNA recombination and transposition. Upon successful completion of this course, students will be able to: discuss the experimental findings that lead to the discovery of inheritance laws; discuss the experimental findings that lead to the identification of DNA as the hereditary material; compare and contrast the structure and function of mRNA, rRNA, tRNA, and DNA; identify the characteristics of catalyzed reactions; compare and contrast enzyme and ribozyme catalyzed reactions; discuss the structure of the chromosome and the consequence of histone modifications in eukaryotes; discuss the stages of transcription, differential splicing, and RNA turnover; predict the translation product of an mRNA using the genetic code; compare and contrast transcription and translation in prokaryotes and eukaryotes; identify codon bias and variations of the standard genetic code; compare and contrast the regulation of prokaryotic and eukaryotic gene expression; predict the activation of an operon and tissue specific gene expression based on the availability of regulators; compare and contrast mutations based on their effect on the gene product; discuss DNA repair mechanisms; discuss DNA recombination, transposition, and the consequence of exon shuffling; design custom-made recombinant DNA using PCR, restriction enzymes, and site-directed mutagenesis; compare and contrast the uses of model organisms; discuss the uses of model organisms in specific molecular biology applications. (Biology 311)

Subject:
Biology
Material Type:
Full Course
Provider:
The Saylor Foundation
Molecular Biology, Spring 2005
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Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and ...

Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature.

Subject:
Literature
Biology
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Baker, Tania
Bell, Stephen
Molecular Biology for the Auditory System, Fall 2002
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An introductory course in the molecular biology of the auditory system. First ...

An introductory course in the molecular biology of the auditory system. First half focuses on human genetics and molecular biology, covering fundamentals of pedigree analysis, linkage analysis, molecular cloning, and gene analysis as well as ethical/legal issues, all in the context of an auditory disorder. Second half emphasizes molecular approaches to function and dysfunction of the cochlea, and is based on readings and discussion of research literature.

Subject:
Biology
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Skvorak Giersch, Anne B.
Molecular Structure of Fat
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Fat is tissue, a type of cell, and a substance. Learn about ...

Fat is tissue, a type of cell, and a substance. Learn about the chemical and molecular structure of fat and how it relates health. A Flash slide show that delves into the various molecular shapes that fat can take. Also featured on the HHMI DVD, Science of Fat, available free from HHMI.

Subject:
Health, Medicine and Nursing
Biology
Chemistry
Material Type:
Reading
Provider:
Howard Hughes Medical Institute
More Than Meets the Eye: The Genetics of Eye Color
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The genetics of eye color are more complex than commonly believed. This ...

The genetics of eye color are more complex than commonly believed. This interrupted case study uses the story of a blue-eyed couple with a brown-eyed child to explore the possible scenarios that could result in this outcome. The case emphasizes the link between Mendelian genetics and the underlying molecular basis of the phenotype. It is appropriate for upper-level undergraduate biology majors with a good understanding of eukaryotic gene regulation and Mendelian genetics.

Subject:
Life Science
Genetics
Material Type:
Case Study
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
Annie PrudĽË_homme Genereux
Mt Hood Community College Biology 102
Conditions of Use:
No Strings Attached
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BI102A is a survey course that introduces the discipline of molecular biology ...

BI102A is a survey course that introduces the discipline of molecular biology and genetics, exploring topics including cell division, protein production, inheritance and gene regulation. This book focuses on putting those topics into an appropriate context for students who are not biology majors.

Subject:
Biology
Material Type:
Textbook
Provider:
OpenOregon
The Mystery of the Seven Deaths: A Case Study in Cellular Respiration
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In this interrupted case study, students learn about the function of cellular ...

In this interrupted case study, students learn about the function of cellular respiration and the electron transport chain and what happens when that function is impaired. The case is loosely based on the real-life 1982 Chicago Tylenol murders where seven people died when Tylenol capsules were laced with cyanide. Students play the role of medical examiner as they analyze the autopsy results to determine the cause of the mysterious deaths of these seven victims. The case was originally used in a general biology course taken by both science majors and non-majors.

Subject:
Life Science
Anatomy/Physiology
Material Type:
Case Study
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
Michaela A. Gazdik
Nematodes
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Genetically modified foods have caused a lot of controversy among environmentalists. Some ...

Genetically modified foods have caused a lot of controversy among environmentalists. Some worry that these so-called "Frankenfoods" might disrupt the ecosystems they grow in, or even threaten human health. But others praise their potential to offset other environmental problems. For example, in this Science Update, you'll hear how genetically engineered tomatoes may be able to resist parasitic worms without the use of toxic pesticides.

Subject:
Engineering
Environmental Science
Ecology
Forestry and Agriculture
Material Type:
Activity/Lab
Lecture
Provider:
AAAS
Provider Set:
Science Netlinks
Not Exactly...: The Complexity of a Human Genetic Disease
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This case study follows a young couple that is consulting with a ...

This case study follows a young couple that is consulting with a genetic counselor about their plans to have a child. Because of their family history with cystic fibrosis, they are concerned about their chances of having a child with this genetic disease. The case study reviews the basics of Mendelian and molecular genetics in humans, briefly examines the possibilities and limitations of genetic testing, and introduces students to online databases, including OMIM, a catalog of human genetic traits. The case also requires students to practice the scientific method, including hypothesis development, experimental design, and the analysis of primary research articles. Although developed for use as an introductory unit to an upper-level genetics course, the case could be adapted for an introductory biology course, perhaps as a closing exercise to a unit on molecular genetics.

Subject:
Life Science
Material Type:
Case Study
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
Dean Fraga
William Morgan
PKU Carriers  How Many Are in Your Hometown?
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In this interrupted case study, students read about a college student with ...

In this interrupted case study, students read about a college student with phenylketonuria (PKU).Ę Students learn how diet affects a person with PKU and how PKU is inherited. The case is designed to introduce introductory biology students to the Hardy-Weinberg Principle. Terms of the equation are related to phenotypes and genotypes mentioned in the case. Given the number of people in the population with PKU and assuming the population is in Hardy-Weinberg Equilibrium, students estimate the number of carriers for PKU in the population. Finally, students estimate the probability that a person from this population with PKU would have a child with PKU and the probability that a person from this population without PKU would have a child with PKU.

Subject:
Life Science
Material Type:
Case Study
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
David J. Grise
Pharmacogenetics: Using Genetics to Treat Disease
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This case study investigates the applications of genetics to medicine by exploring ...

This case study investigates the applications of genetics to medicine by exploring one of the first examples of a pharmacogenetic test to enter mainstream clinical practice. Pharmacogenetics examines how genetic variations in an individual correlate with responses to a specific medication in order to develop tailored medical treatments. Through a scenario based on clinical observations, students learn about acute lymphocytic leukemia as well as the wide range of individual responses to the drug used to treat it. Then, students interpret data similar to those initially published in scientific journals in order to construct an understanding of how genetic variation can be used to "tailor" medical care. Lastly, students are asked to apply their understanding of what they have learned in the case by making the appropriate medical recommendation based on a particular individual's genotype.

Subject:
Engineering
Health, Medicine and Nursing
Life Science
Genetics
Material Type:
Case Study
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
Jeanne Ting Chowning
Phenylketonuira
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In this activity, students are assigned different alleles of the gene for ...

In this activity, students are assigned different alleles of the gene for phenylalanine hydroxylase to research using OMIM (Online Mendelian Inheritance in Man). They are then asked to both explain and illustrate how this mutation may cause the disease phenylketonuria (PKU).

Subject:
Education
Life Science
Genetics
Material Type:
Activity/Lab
Assessment
Data Set
Homework/Assignment
Provider:
Science Education Resource Center (SERC) at Carleton College
Provider Set:
Pedagogy in Action
Starting Point (SERC)
Author:
Scott Cooper
The Physiology of a Neurodegenerative Disease: Huntington's Disease
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In this case, a young woman learns that her uncle has been ...

In this case, a young woman learns that her uncle has been diagnosed with Huntington's disease. She talks with her fellow graduate students to try to better understand the physiology of the disorder, along with the medical and personal implications for the patient and his caregivers. Students review scientific papers to help them address a series of guided questions about the symptoms and care; the roles of membrane potential, neurotransmitters and cell death; and experimental approaches to understanding the disease. The case encourages students to integrate ideas from a range of biology disciplines to develop a conceptual framework for what is currently known about Huntington's. Developed for an upper-level college physiology course, this case could also be appropriate for classes on cell biology, molecular biology, or genetics.

Subject:
Life Science
Anatomy/Physiology
Material Type:
Case Study
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
Christine M. Fleet
Poor Devils: The Plight of the Tasmanian Devils
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Cancer is usually thought to be a disease that affects individuals. But ...

Cancer is usually thought to be a disease that affects individuals. But could cancer evolve to become infectious? This case follows the research on a form of transmissible cancer that is decimating the Tasmanian devil, the world's largest carnivorous marsupial. Students analyze two landmark papers that uncovered the molecular mechanism of this cancer, which is known as Tasmanian Devil Facial Tumor Disease (DFTD). Through this case, students develop an understanding of cancer, immunology, microbiology, and cytogenetics in addition to becoming more comfortable using primary research literature. The case was developed for third-year biology students in a molecular biology course, but may also be used in courses in genetics, evolution, immunology, conservation, and research methods.

Subject:
Life Science
Ecology
Forestry and Agriculture
Material Type:
Case Study
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
Annie PrudĽË_homme Genereux