Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing Program in assessing longevity variation across 22 Caenorhabditis strains spanning 3 species, using multiple replicates collected across three independent laboratories. Reproducibility between test sites is high, whereas individual trial reproducibility is relatively low. Of ten pro-longevity chemicals tested, six significantly extend lifespan in at least one strain. Three reported dietary restriction mimetics are mainly effective across C. elegans strains, indicating species and strain-specific responses. In contrast, the amyloid dye ThioflavinT is both potent and robust across the strains. Our results highlight promising pharmacological leads and demonstrate the importance of assessing lifespans of discrete cohorts across repeat studies to capture biological variation in the search for reproducible ageing interventions.

The purpose of this curriculum is to heighten the awareness and increase knowledge of child welfare workers, foster care providers, and school staff regarding the educational needs of foster children and to develop specific skills to address those needs and smooth the transition to new school environments in order to avoid unnecessary absences from school caused by transferring to a new foster home. The process requires a three-way collaborative effort between the caseworker, foster care provider, and school staff, and this curriculum provides clear, concise, and practicable actions for all of the responsible professionals to enable them to operate effectively as part of a collaborative team. (209 pages)Berrick, J. D., Ayasse, R. H. (2005).

This collection uses primary sources to explore Incidents in the Life of a Slave Girl by Harriet Jacobs. Digital Public Library of America Primary Source Sets are designed to help students develop their critical thinking skills and draw diverse material from libraries, archives, and museums across the United States. Each set includes an overview, ten to fifteen primary sources, links to related resources, and a teaching guide. These sets were created and reviewed by the teachers on the DPLA's Education Advisory Committee.

This is a collection of complex literary texts and prompts which can be used to develop text dependent analysis skills.  This set is identified for grade 6 but can be used with other grades as determined by curriculum and the learners. The prompts are intended to be used as part of an instructional routine, but they can also be used as stand-alone benchmarks.  

This is a collection of complex texts, both literary and informational, which can be used to develop text dependent analysis skills appropriate for grade 8.  For each text, there is at least one TDA prompt (in separate documents).  

This course is an introduction to mathematical modeling of computational problems, as well as common algorithms, algorithmic paradigms, and data structures used to solve these problems. It emphasizes the relationship between algorithms and programming and introduces basic performance measures and analysis techniques for these problems.

Data Carpentry lesson to learn how to work with Amazon AWS cloud computing and how to transfer data between your local computer and cloud resources. The cloud is a fancy name for the huge network of computers that host your favorite websites, stream movies, and shop online, but you can also harness all of that computing power for running analyses that would take days, weeks or even years on your local computer. In this lesson, you’ll learn about renting cloud services that fit your analytic needs, and how to interact with one of those services (AWS) via the command line.

Data Carpentry lesson to understand data structures and common storage and transfer formats for spatial data. The goal of this lesson is to provide an introduction to core geospatial data concepts. It is intended for learners who have no prior experience working with geospatial data, and as a pre-requisite for the R for Raster and Vector Data lesson . This lesson can be taught in approximately 75 minutes and covers the following topics: Introduction to raster and vector data format and attributes Examples of data types commonly stored in raster vs vector format Introduction to categorical vs continuous raster data and multi-layer rasters Introduction to the file types and R packages used in the remainder of this workshop Introduction to coordinate reference systems and the PROJ4 format Overview of commonly used programs and applications for working with geospatial data The Introduction to R for Geospatial Data lesson provides an introduction to the R programming language while the R for Raster and Vector Data lesson provides a more in-depth introduction to visualization (focusing on geospatial data), and working with data structures unique to geospatial data. The R for Raster and Vector Data lesson assumes that learners are already familiar with both geospatial data concepts and the core concepts of the R language.

Data Carpentry lesson to open, work with, and plot vector and raster-format spatial data in R. The episodes in this lesson cover how to open, work with, and plot vector and raster-format spatial data in R. Additional topics include working with spatial metadata (extent and coordinate reference systems), reprojecting spatial data, and working with raster time series data.

This workshop introduces the basic concepts of Git version control. Whether you're new to version control or just need an explanation of Git and GitHub, this two hour tutorial will help you understand the concepts of distributed version control. Get to know basic Git concepts and GitHub workflows through step-by-step lessons. We'll even rewrite a bit of history, and touch on how to undo (almost) anything with Git. This is a class for users who are comfortable with a command-line interface.

This class is designed for first-time and longer-term users of Jupyter Notebooks, a workspace for writing code. The class focuses on using Notebooks to facilitate sharing and publishing of script workflows. It aims to provide users with knowledge about shortcuts, plugins, and best practices for maximizing re-usability and shareability of Notebook contents.

This video will introduce how to calculate statistical power in R using the pwr package.

All materials shown in the video, as well as content from our other videos, can be found here: https://osf.io/7gqsi/.

This is a recording of a 45 minute introductory webinar on preprints. With our guest speaker Philip Cohen, we’ll cover what preprints/postprints are, the benefits of preprints, and address some common concerns researcher may have. We’ll show how to determine whether you can post preprints/postprints, and also demonstrate how to use OSF preprints (https://osf.io/preprints/) to share preprints. The OSF is the flagship product of the Center for Open Science, a non-profit technology start-up dedicated to improving the alignment between scientific values and scientific practices. Learn more at cos.io and osf.io, or email contact@cos.io.

In this webinar, Doctors David Mellor (Center for Open Science) and Stavroula Kousta (Nature Human Behavior) discuss the Registered Reports publishing workflow and the benefits it may bring to funders of research. Dr. Mellor details the workflow and what it is intended to do, and Dr. Kousta discusses the lessons learned at Nature Human Behavior from their efforts to implement Registered Reports as a journal.

The goal of this lesson is to provide an introduction to R for learners working with geospatial data. It is intended as a pre-requisite for the R for Raster and Vector Data lesson for learners who have no prior experience using R. This lesson can be taught in approximately 4 hours and covers the following topics: Working with R in the RStudio GUI Project management and file organization Importing data into R Introduction to R’s core data types and data structures Manipulation of data frames (tabular data) in R Introduction to visualization Writing data to a file The the R for Raster and Vector Data lesson provides a more in-depth introduction to visualization (focusing on geospatial data), and working with data structures unique to geospatial data.

This video is an introduction to power analyses to improve the reproducibility of your research.

This class introduces students to innovative as well as classic approaches to studying U.S. government. The writing assignments will help you explore, through a variety of lenses, statis and change in the American political system over the last three decades. In the end each student will have a solid grounding in our national political institutions and processes, sharper reading and writing skills, and insight into approaching politics critically and analytically.

Command line interface (OS shell) and graphic user interface (GUI) are different ways of interacting with a computer’s operating system. The shell is a program that presents a command line interface which allows you to control your computer using commands entered with a keyboard instead of controlling graphical user interfaces (GUIs) with a mouse/keyboard combination. There are quite a few reasons to start learning about the shell: The shell gives you power. The command line gives you the power to do your work more efficiently and more quickly. When you need to do things tens to hundreds of times, knowing how to use the shell is transformative. To use remote computers or cloud computing, you need to use the shell.

Data Carpentry lesson to learn to navigate your file system, create, copy, move, and remove files and directories, and automate repetitive tasks using scripts and wildcards with genomics data. Command line interface (OS shell) and graphic user interface (GUI) are different ways of interacting with a computer’s operating system. The shell is a program that presents a command line interface which allows you to control your computer using commands entered with a keyboard instead of controlling graphical user interfaces (GUIs) with a mouse/keyboard combination. There are quite a few reasons to start learning about the shell: For most bioinformatics tools, you have to use the shell. There is no graphical interface. If you want to work in metagenomics or genomics you’re going to need to use the shell. The shell gives you power. The command line gives you the power to do your work more efficiently and more quickly. When you need to do things tens to hundreds of times, knowing how to use the shell is transformative. To use remote computers or cloud computing, you need to use the shell.

http://ntvmr.uni-muenster.de
This is a brief introduction to the New Testament Virtual Manuscript Room at The Institut für neutestamentliche Textforschung in Münster. This video will walk you through creating an account and using basic features of the NTVMR.