This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Colorectal cancer is the third most frequently diagnosed cancer and the second leading cause of cancer-related death in the world. Understanding the associated mechanisms is critical to the development of strategies to treat patients with colorectal cancer. Emerging evidence suggests that LOXL1, a lysyl oxidase, is a promising drug candidate for its effects on malignant cancer progression. Now, a molecular-level study could indicate why. Researchers examined the effects of LOXL1 on tumorigenicity and metastasis ability in lab-grown colorectal tumor cells and mouse xenografts. In vitro, LOXL1 overexpression dramatically reduced migration, invasion, and colony formation. In mice, LOXL1 overexpression drastically inhibited metastatic progression and tumor growth. Further experiments showed that LOXL1 exerted its effects by inhibiting the transcriptional activity of Yes-associated protein (YAP). by interacting with MST1/2 and increasing the phosphorylation of MST1/2 thereby activating the Hippo signaling pathway..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

October 1915–April 1918

Word Count: 41743

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Lyme disease in humans and other vertebrates is caused by _Borrelia burgdorferi_. This spirochete pathogen lives in the midgut of ticks and migrates to their salivary glands to be transmitted to vertebrate hosts. But the midgut contains other bacterial species, many of which are symbionts of the tick, and how this microbiome impacts spirochete migration remains unclear. So, a recent study examined this interaction in the blacklegged tick, the predominant transmitter of _B. burgdorferi_ in the US. However, changes to the midgut microbiome composition via external exposure to other bacteria did not impact _B. burgdorferi_ migration or its transmission to mice. Within 24 to 48 hours of the onset of tick feeding, _B. burgdorferi _(B) are in the cells at the border of the midgut, ready to exit..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Glioblastoma (GBM), an aggressive cancer in the brain or spinal cord, is a devastating diagnosis. Although therapies exist, GBM has a poor prognosis, with a median survival of only 14-15 months after diagnosis. Key to its aggressiveness is the degree to which migrating GBM cells infiltrate adjacent brain tissue. GBM cells express the protein MACC1, which is a marker of metastasis and tumor cell migration. Unfortunately, how GBM cells learn to migrate is unclear. A recent study used live-cell and atomic force microscopy to evaluate cell migration and mechanical properties of GBM cells overexpressing MACC1. The results showed that MACC1 increased the migratory speed and elasticity of GBM cells while it decreased cell-cell adhesion and inhibited aggregation. MACC1-overexpressing cells also had specific increases in protrusive actin, allowing the cells to adhere to laminin..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Renal cell carcinoma (RCC) is one of the most common cancers in the United States. The most frequent form of RCC, clear cell RCC (ccRCC), is particularly aggressive with high mortality. Thus, there is an urgent need for prognostic tools and treatments. The protein Integrin β4 (ITGB4) plays important roles in other malignancies, but its role in ccRCC is not well documented. A recent study confirmed that ITGB4 was significantly overexpressed in ccRCC tissues and that high levels predicted metastasis and a poor prognosis. ITGB4 stimulated cell migration and invasion in benchtop experiments and metastasis in a mouse model. Another protein, methyltransferase-like 14 (METTL14), accelerated the degradation of ITGB4 mRNA, ultimately reducing ITGB4's expression. METTL14 did this by facilitating the addition of a methyl group to an adenosine on the end of ITGB4 mRNA. The modified ITGB4 mRNA is then bound by YTH domain family protein 2 (YTHDF2), which promotes the decay of the mRNA..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The aim of this manual is to train the participants to become intercultural coaches in their own territory by having acquired the necessary basics. An intercultural guide is a person, who has a personal sensitivity to the theme of migration, most of the time based on his or her own experience and who proposes to third parties, tourists, citizens, to discover a district, a city through his or her own eyes and his or her own history. The content of this manual aims, in the form of evening classes, to offer, in all the territories of the large European urban cities and even elsewhere, the acquisition of the essential notions allowing the conception of such intercultural urban itineraries. Four training modules, each consisting of three units, are proposed and presented in the form of a slide show. The training units are structured around Key Concepts, definitions and explanations, examples and elements of conclusions.The training modules consist of:● Module 1 - Know your territory and identify tourism stakeholders● Module 2 - Design intercultural tourist routes● Module 3 - Conduct intercultural tourist routes● Module 4 - Present your project All modules are also available in 6 languages on : https://citiesbyheart.aeva.eu/index.php/portfolios/io2/

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Melanoma is a dangerous skin cancer that can quickly become resistant to treatment, in part through interactions between cancer cells and their surroundings. For example, melanoma cells can secrete factors that activate fibroblasts in the tumor microenvironment, and the resulting cancer-associated fibroblasts (CAFs) facilitate cancer progression. However, the exact interactions between melanoma cells and CAFs remain unclear. To learn more, researchers recently cultured normal human fibroblasts with melanoma cells or melanoma-secreted proteins in vitro. They confirmed that the normal fibroblasts became CAFs with enhanced migration, invasion, and matrix protein degradation abilities, which are properties that facilitate cancer progression. The levels of immune molecules called cytokines and proteins related to blood vessel formation were also upregulated in the CAFs, and secretion of lactate, a common end product of cancer cell metabolism, was increased..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Migrant construction workers from rural China describe their living conditions in Beijing in this Wide Angle video segment.

Chinese migrant workers give insight into their status, lack of power and vulnerability in the new economic order in this video from Wide Angle.

Thousands of orange and black shapes flutter through the trees. Welcome to one of the few wintering homes of the monarch butterfly. Also in: Spanish

Since the Russian annexation of Crimea in 2014 and the beginning of the war in Donbas, Eastern Europe has been facing a migration crisis. Several million Ukrainians are internally displaced or have fled the country and now face an uncertain future. At the same time, Western-imposed sanctions and the creation of the Eurasian Economic Union have affected Russia’s migration policies. These largely ignored processes have a potential to change the social landscape of the region for many years to come. The aim of this collection is to shed light on the forgotten migrant crisis at the European Union’s doorstep and make sense of the various migration processes in and out of Ukraine and Russia. The book is divided into two sections. The first section deals with migration processes that have taken place within Ukraine or have involved Ukrainian citizens’ migration out of the country, excluding Russia. The second section discusses Russia’s response to the rapid inflow of migrants from Ukraine, its changing migration policies and their effect on migrants, as well as other processes related to the phenomenon over the course of the Ukraine crisis.

This video segment from NOVA: "The Mystery of Animal Pathfinders" explores the migratorial exploits of monarch butterflies.

Students will learn about Wyoming’s pronghorn population and the challenges it faces from human activity. Students will watch portions of the PBS documentary “Migrations” to learn about the pronghorn and how humans are working to protect the pronghorn’s migration route.

Students will learn about the animals that use the migration corridor that stretches from the Grand Tetons in Northwest Wyoming to the Red Desert in South Central Wyoming. Students will watch portions of the PBS documentary “Migrations” to learn about about the challenges these species face. Students will identify threats to animals that use the migration corridor and develop potential solutions that could reduce the negative impact of human activities.

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

The purpose of this assignment is to help you think about what it would’ve been like to have experienced the Mormon Migration. The people who participated in this historic event left many things behind, including their homes, families, jobs, etc.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Despite advances in therapy, the prognosis and survival of patients with glioblastoma remain dismal. Part of the reason is poor targeting. The sheer complexity of tumor growth at the molecular scale makes it difficult to pinpoint the origin of gliomas. In recent years, more targeted research has led to the discovery of chains of molecular events that regulate glioma development, including the unusual trafficking of proteins into the nucleus of glioma cells. In a new study, researchers examined this glioma-related behavior for the protein doublecortin (DCX). DCX is a neuronal protein crucial for the formation of new neurons in adulthood and for neuronal migration. While researchers have looked at how glioma cells shuttle different proteins to their nucleus, this marked the first time that scientists zeroed in on DCX. The team found that high accumulation of DCX in the nucleus boosted the invasiveness of glioma cells, whereas blocking the nuclear import of DCX reduced glioma proliferation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Since the mid-l970s, economic reforms have transformed China from one of the most egalitarian societies into one of the most unequal in the world. Wide disparities currently exist between the income levels of a relatively few rich and middle-class Chinese and their fellow citizens who number in the hundreds of millions. This "wealth gap" is particularly acute when one compares the incomes of urban and rural residents, between Chinese living in the interior of the country and those living in the rapidly developing cities on China's eastern coast.The causes of the growing income gap include previous governmental policies that favored city dwellers over farmers, the uneven regional patterns of foreign investment, and the massive outflow of displaced farmers to China's already overcrowded cities in pursuit of manufacturing jobs.Recently, the Chinese government, in recognition of the potential for social instability, and in the face of growing unrest amongst China's poor, has made the elimination of economic and social inequalities a top priority. Plans are in motion to build a more "harmonious society" through the delivery of improved educational and health services to those who appear to have been left behind in China's rush to modernize its economy.This lesson, using clips from the WIDE ANGLE film "To Have and Have Not" (2002), can be used after a lesson on the Communist Revolution and Mao's rule. A basic knowledge of China's geography, of the tenets of Chinese Communism, and of Mao's efforts to redirect the course of China's future by means of the Cultural Revolution, is required for the successful completion of the lesson.

The movement of people and goods is an important part of the New York State Global History and Geography Curriculum. It is listed as one of the themes that are emphasized in the core curriculum. Students are expected to understand why people migrate and what the impact of migrations has been on people, nations, and regions. Recently, the PBS WIDE ANGLE documentary series created two programs that relate to the movement of people. 'Border Jumpers' (2005) documents migration between countries in Africa, and 'To Have and Have Not' (2002) deals with migration from rural to urban areas in China. By studying these two migrations, students can deepen their understanding of events and trends in Africa and China since World War II. A study of these two migrations can also provide students with a framework for reviewing other migrations included in the core curriculum and help students to prepare for possible thematic essays on the Regents exam. The purpose of this lesson is to show the reasons why people are migrating in Africa and China today and how these migrations are impacting those regions. In addition, students will be motivated to critically analyze national immigration policies and to consider the relevance of national borders in a world that is experiencing rapid globalization. As a culminating activity, students will outline a response for a sample Regents thematic essay question and will be assigned to write the essay for homework.