This site is an OER lab manual for a college level genetics course.

This document contains eight genetic problems with multiple parts.  These include crosses in which only one character are studied, crosses in which two characters are studied, crosses with multiple alleles, and crosses that are sex-linked.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new study published in Genome Medicine adds to the growing body of evidence that Parkinson’s disease is linked to microbes in the gut. Investigating the composition and function of this microbial community, the research team found pronounced differences between healthy patients and those in the early stages of the disease. Parkinson’s disease is most commonly associated with tremors, muscle stiffness, and impaired movement. While these symptoms are caused by the breakdown of nerve cells in the brain, the root cause and progression of this disorder are still not fully understood. Emerging evidence, however, suggests microorganisms found in the intestines may have something to do with it. The human gut contains trillions of microbes, including bacteria, archaea, fungi, and viruses. These organisms, collectively termed the microbiome, have been suggested to profoundly impact human health and disease..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This guide was created to provide definitions and resources for bioinformatics and genomics terms frequently seen in literature. Each term has been linked to it's original source for additional information and resources. This guide is intended for anyone who is interested in learning more about bioinformatics or genomics. Designed to provide concise yet easy to understand definitions, this allows users with any background level in genomics and bioinformatics to gain a better understanding of some commonly used terms and phrases.

This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed. In addition to the regular lecture sessions, supplementary sections are scheduled to address issues related to Perl, Mathematica and biology.

This article is designed to help students and teachers think about the nature of various determinants underlying biological variation. Teachers facilitating any selection investigation will find this background information helpful, including those planning for the AP Biology Lab 1 of Big Idea 1: Evolution, Artificial Selection. Learners at secondary or tertiary grade levels who are preparing to investigate variation or are working on interpreting variation data can also use this resource.

The Greenomes site is part of a laboratory- and Internet-based curriculum to bring college students up to the minute with modern plant research. Plant molecular genetic and genomic research still lags behind medically-oriented research on microbes and higher animals. As a result, there are relatively few lab experiences that expose college-level students to the growing insights into plants offered by genomic biology.

This blog post, written by the MiniPCR Team, describes the use of biotechnology kits and equipment (available from multiple suppliers) in the classroom to help students and learners understand the connection between observable phenotypic traits and underlying genotypes. These investigations can be approached at varying complexity, incorporating plant breeding and growing plants through their whole life cycle, depending on teaching goals. This post includes links to the necessary seeds and options for biotechnology equipment/materials to accomplish these investigations.

Instructional video on how DNA binding proteins recognize their target sequences in DNA.

Although textbooks describe this process and show illustrations, it is difficult to grasp without seeing a live demonstration.

Created for Biology 41 General Genetics at Tufts University.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Chloroplasts harness sunlight to power all the processes that help plants grow. Like engines, they must carefully balance their fuel to run efficiently. In plants, that’s the ratio of ATP to NADPH, two forms of fuel produced by photosynthesis. But scientists have long known that ATP/NADPH ratios in chloroplasts fall short of the value required for plants to turn CO₂ into sugars. To find out how plants overcome this imbalance, researchers tracked ATP in Arabidopsis plants in real time using a fluorescent protein sensor. They found that immature chloroplasts in young seedlings imported cytosolic ATP for chloroplast biogenesis, using an abundance of ATP transporter proteins to do the job, but mature chloroplasts downregulated these transporters to minimize ATP importation. Instead of importing ATP to maintain fuel balance, chloroplasts exported NADPH in the form of malate..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The brain is the most complex biological structure known. All thoughts, movements, and behaviors are coordinated in this control center, where information is processed and transmitted in the form of electrical impulses and chemical signals. It perhaps comes as no surprise then, that alterations in this function can lead to neurological and psychiatric disorders. Now, a new study has pinpointed specific regions of a gene expressed in brain cells that appear to be associated with conditions such as developmental delay and intellectual disability. Neurodevelopmental disorders present early in life and are caused by impairments of growth, development, and function of the brain and central nervous system. With conditions including autism, attention deficit disorder, and schizophrenia, these disorders are characterized by deficits in cognitive, social, or personal functioning..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Most genetic studies of Alzheimer’s disease compare patient DNA to controls to identify mutations that increase disease risk. That approach has identified some risk variants, but none have led to effective treatments, and most of the genetic contributors are still unknown. Now, a team of researchers is tackling the problem from the opposite side, asking why some high-risk elderly people don’t have Alzheimer’s – a strategy that has discovered a protective mutation in a gene that may be a good drug target. To find protective mutations for Alzheimer’s, the scientists first searched the Utah Population Database for families with above-average rates of Alzheimer's that also had at least four people who were resilient to the disease -- that is, they were cognitively normal, despite being 75 years old or older, and having the APOE e4 allele, which increases risk more than 5-fold per copy..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This is the introduction of our Neuroscience open-access textbook. The content of this chapter focuses on giving studnets an overview of the brain and behavior before diving into specific topics. 

7.016 Introductory Biology provides an introduction to fundamental principles of biochemistry, molecular biology, and genetics for understanding the functions of living systems. Taught for the first time in Fall 2013, this course covers examples of the use of chemical biology and twenty-first-century molecular genetics in understanding human health and therapeutic intervention.
The MIT Biology Department Introductory Biology courses 7.012, 7.013, 7.014, 7.015, and 7.016 all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.

The MIT Biology Department core Introductory Biology courses, 7.012, 7.013, 7.014, 7.015, and 7.016 all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. The focus of 7.013 is on genomic approaches to human biology, including neuroscience, development, immunology, tissue repair and stem cells, tissue engineering, and infectious and inherited diseases, including cancer.

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. 7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution.
Biological function at the molecular level is particularly emphasized in all courses and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.

This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on RNA engineering, protein engineering, and cell-biomaterial engineering.
This OCW site is based on the source OpenWetWare class Wiki, 20.109(S10): Laboratory Fundamentals of Biological Engineering.

This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, rigorous data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on genome engineering, expression engineering, and biomaterial engineering.
This OCW site is based on the source OpenWetWare class Wiki, found at 20.109(F07): Laboratory Fundamentals of Biological Engineering.

This is a worksheet (with sample answers for instructors) that was developed to help learners get a better understanding of the nuances related to the regulation of the Lac operon, and to provide them with opportunities to practice analytical thinking. We have used it for years in the biology component of a first year university science course (for science majors).