This course provides an introduction to linear systems, transfer functions, and Laplace transforms. It covers stability and feedback, and provides basic design tools for specifications of transient response. It also briefly covers frequency-domain techniques.

This lesson introduces students to the art of designing an airplane through paper airplane constructions. The goal is that students will learn important aircraft design considerations and how engineers must iterate their designs to achieve success. Students first follow several basic paper airplane models, after which they will then design their own paper airplane. They will also learn how engineers make models to test ideas and designs.

This course covers the thermo-fluid dynamic phenomena and analysis methods for conventional and nuclear power stations. Specific topics include: kinematics and dynamics of two-phase flows; steam separation; boiling, instabilities, and critical conditions; single-channel transient analysis; multiple channels connected at plena; loop analysis including single and two-phase natural circulation; and subchannel analysis.

This course is an advanced topics course on market and mechanism design. We will study existing or new market institutions, understand their properties, and think about whether they can be re-engineered or improved. Topics discussed include mechanism design, auction theory, one-sided matching in house allocation, two-sided matching, stochastic matching mechanisms, student assignment, and school choice.

The airplanes unit begins with a lesson on how airplanes create lift, which involves a discussion of air pressure and how wings use Bernoulli's principle to change air pressure. Next, students explore the other three forces acting on airplanes thrust, weight and drag. Following these lessons, students learn how airplanes are controlled and use paper airplanes to demonstrate these principles. The final lessons addresses societal and technological impacts that airplanes have had on our world. Students learn about different kinds of airplanes and then design and build their own balsa wood airplanes based on what they have learned.

What makes rockets fly straight? What makes rockets fly far? Why use water to make the rocket fly? Students are challenged to design and build rockets from two-liter plastic soda bottles that travel as far and straight as possible or stay aloft as long as possible. Guided by the steps of the engineering design process, students first watch a video that shows rocket launch failures and then participate in three teacher-led mini-activities with demos to explore key rocket design concepts: center of drag, center of mass, and momentum and impulse. Then the class tests four combinations of propellants (air, water) and center of mass (weight added fore or aft) to see how these variables affect rocket distance and hang time. From what they learn, student pairs create their own rockets from plastic bottles with cardboard fins and their choices of propellant and center of mass placement, which they test and refine before a culminating engineering field day competition. Teams design for maximum distance or hang time; adding a parachute is optional. Students learn that engineering failures during design and testing are just steps along the way to success.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Much recent research points toward a strong link between the microorganisms living in the gut and human health. Changes in this microbial community as a person grows older are thought to stem from changes in lifestyle and wellbeing associated with modern society, but evidence to support this claim is lacking. To gain a better understanding of how age affects the gut microbial community under natural conditions, researchers looked toward wild macaques. Using gene sequencing techniques, they found that the gut bacterial composition of individual macaques exhibited a unique personal signature and that this signature became increasingly unstable with age. This instability was linked to an increase in the relative abundance of rare bacterial groups. The uniqueness of an individual’s gut microbiota also increased with age, potentially due in part to a decrease in social interaction..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Breast cancer is the most common type of cancer in women worldwide. More than 70% of breast cancers are estrogen receptor alpha (ERα) positive, indicating that they might be treatable with endocrine therapy. However, half of patients with ERα-positive breast cancer develop endocrine resistance, a major roadblock to successful therapy. In a new study, researchers sought to learn more about ERα-positive breast cancer to support the development of better treatments. The enzyme TRIM3, a regulator of protein stability vs. breakdown, was upregulated in ERα-positive breast cancer tissues, and high TRIM3 expression was associated with poor survival in patients receiving endocrine therapy. In experiments on mice and cell lines, TRIM3 promoted ERα signaling and was required for cancer growth and migration. Specifically, the filamin/NHL domain of TRIM3 bound to the DNA-binding domain of ERα in the nucleus..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotic-resistant bacteria like carbapenem-resistant Enterobacteriaceae (CRE) pose a serious threat to human health. Some resistant pathogens can exist alongside our commensal microbiota at undetectable levels. Antibiotic use can lead to outgrowth of these subclinically colonized bacteria. A recent study sought to better understand the interaction between the gut microbiota and CRE during subclinical colonization and outgrowth. First, researchers exposed wild-type mice to the CRE _K. pneumoniae_. While the levels of _K. pneumoniae_ were not detectable after exposure, the post-exposure microbiome was disrupted. Then, administration of an antibiotic cocktail, ampicillin, vancomycin, or azithromycin induced _K. pneumoniae_ outgrowth while reducing overall microbial diversity. Vancomycin only induced outgrowth in a subset of mice. The researchers found these outgrowth-susceptible mice had differences in mRNA stability pathways and xylose abundance..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.