Students reinforce their knowledge that DNA is the genetic material for all living things by modeling it using toothpicks and gumdrops that represent the four biochemicals (adenine, thiamine, guanine, and cytosine) that pair with each other in a specific pattern, making a double helix. They investigate specific DNA sequences that code for certain physical characteristics such as eye and hair color. Student teams trade DNA "strands" and de-code the genetic sequences to determine the physical characteristics (phenotype) displayed by the strands (genotype) from other groups. Students extend their knowledge to learn about DNA fingerprinting and recognizing DNA alterations that may result in genetic disorders.

As a class, students work through an example showing how DNA provides the "recipe" for making our body proteins. They see how the pattern of nucleotide bases (adenine, thymine, guanine, cytosine) forms the double helix ladder shape of DNA, and serves as the code for the steps required to make genes. They also learn some ways that engineers and scientists are applying their understanding of DNA in our world.

Students are given a biomedical engineering challenge, which they solve while following the steps of the engineering design process. In a design lab environment, student groups design, create and test prototype devices that help people using crutches carry things, such as books and school supplies. The assistive devices must meet a list of constraints, including a device weight limit and minimum load capacity. Students use various hand and power tools to fabricate the devices. They test the practicality of their designs by loading them with objects and then using the modified crutches in the school hallways and classrooms.

Students are introduced to engineering, specifically to biomedical engineering and the engineering design process, through a short lecture and an associated hands-on activity in which they design their own medical devices for retrieving foreign bodies from the ear canal. Through the lesson, they learn the basics of ear anatomy and how ear infections occur and are treated. Besides antibiotic treatment, the most common treatment for chronic ear infections is the insertion of ear tubes to drain fluid from the middle ear space to relieve pressure on the ear drum. Medical devices for this procedure, a very common children's surgery, are limited, sometimes resulting in unnecessary complications from a simple procedure. Thus, biomedical engineers must think creatively to develop new solutions (that is, new and improved medical devices/instruments) for inserting ear tubes into the ear drum. The class learns the engineering design process from this ear tube example of a medical device design problem. In the associated activity, students explore biomedical engineering on their own by designing prototype medical devices to solve another ear problem commonly experienced by children: the lodging of a foreign body (such as a pebble, bead or popcorn kernel) in the ear canal. The activity concludes by teams sharing and verbally analyzing their devices.

Students learn the engineering design process by following the steps, from problem identification to designing a device and evaluating its efficacy and areas for improvement. A quick story at the beginning of the activity sets up the challenge: A small child put a pebble in his ear and we don't know how to get it out! Acting as biomedical engineers, students are asked to design a device to remove it. Each student pair is provided with a model ear canal and a variety of classroom materials. A worksheet guides the design process as students create devices and attempt to extract pebbles from the ear canal.

To reinforce students' understanding of the human digestion process, the functions of several stomach and small intestine fluids are analyzed, and the concept of simulation is introduced through a short, introductory demonstration of how these fluids work. Students learn what simulation means and how it relates to the engineering process, particularly in biomedical engineering. The teacher demo requires vinegar, baking soda, water and aspirin.

Students demonstrate the erythrocyte sedimentation rate test (ESR test) using a blood model composed of tomato juice, petroleum jelly and olive oil. They simulate different disease conditions, including rheumatoid arthritis, anemia, leukocytosis and sickle-cell anemia, by making appropriate variations in the particle as well as in the fluid matrix. Students measure the ESR for each sample blood model, correlate the ESR values with disease conditions and confirm that diseases alter blood composition and properties. During the activity, students learn that when non-coagulated blood is let to stand in a tube, the red blood cells separate and fall to the bottom of the tube, resulting in a sediment and a clear liquid called serum. The height in millimeters of the clear liquid on top of the sediment in a time period of one hour is taken as the sedimentation rate. If a disease is present, this ESR value deviates from the normal, disease-free value. Different diseases cause different ESR values because blood composition and properties, such as density and viscosity, are altered differently by different diseases. Thus, the ESR test serves as a real-world diagnostic screening test to identify indications of the presence of any diseases in people.

Students further their understanding of the engineering design process (EDP) while applying researched information on transportation technology, materials science and bioengineering. Students are given a fictional client statement (engineering challenge) and directed to follow the steps of the EDP to design prototype patient safety systems for small-size model ambulances. While following the steps of the EDP, students identify suitable materials and demonstrate two methods of representing solutions to the design challenge (scale drawings and small-scale prototypes). A successful patient safety system meets all of the project's functions and constraints, including the model patient (a raw egg) "surviving" a front-end collision test with a 1:8 ramp pitch.

Students extend their knowledge of the skeletal system to biomedical engineering design, specifically the concept of artificial limbs. Students relate the skeleton as a structural system, focusing on the leg as structural necessity. They learn about the design considerations involved in the creation of artificial limbs, including materials and sensors.

Imagining themselves arriving at the Olympic gold medal soccer game in Beijing, students begin to think about how engineering is involved in sports. After a discussion of kinetic and potential energy, an associated hands-on activity gives students an opportunity to explore energy absorbing materials as they try to protect an egg from being crushed.

The course covers basic concepts of biomedical engineering and their connection with the spectrum of human activity. It serves as an introduction to the fundamental science and engineering on which biomedical engineering is based. Case studies of drugs and medical products illustrate the product development-product testing cycle, patent protection, and FDA approval. It is designed for science and non-science majors.

Students are challenged to think as biomedical engineers and brainstorm ways to administer medication to a patient who is unable to swallow. They learn about the advantages and disadvantages of current drug delivery methods—oral, injection, topical, inhalation and suppository—and pharmaceutical design considerations, including toxicity, efficacy, size, solubility/bioavailability and drug release duration. They apply their prior knowledge about human anatomy, the circulatory system, polymers, crystals and stoichiometry to real-world biomedical applications. A Microsoft® PowerPoint® presentation and worksheets are provided. This lesson prepares students for the associated activity in which they create and test large-size drug encapsulation prototypes to provide the desired delayed release and duration timing.

Students will answer the Challenge Question and use the acquired learning from Lesson 1, "Fix the Hip Challenge" and Lesson 2, "Skeletal System Overview"to construct an informative brochure addressing osteoporosis and the role biomedical engineering plays in diagnosing and preventing this disease.

This lesson introduces the MRI Safety Grand Challenge question. Students are asked to write journal responses to the question and brainstorm what information they will need to answer the question. The ideas are shared with the class and recorded. Students then watch a video interview with a real life researcher to gain a professional perspective on MRI safety and brainstorm any additional ideas. The associated activity provides students the opportunity to visualize magnetic fields.

This lesson introduces the Bone Module Grand Challenge question. Students are asked to write their initial responses to the question alone. They will then brainstorm ideas with one other student. Finally, the ideas are shared with the class and recorded. It is important for students to gather information to decide whether or not this condition is hereditary. Students then watch two videos about osteoporosis. Grand Challenge Question: When you get home from school, your mother grabs you, and you rush to the hospital. Your grandmother fell and was rushed to the emergency room. The doctor tells your family your grandmother has a fractured hip, and he is referring her to an orthopedic specialist. The orthopedic doctor decides to perform a DEXA scan. The result showed her bone mineral density (BMD) was -3.3. What would be a probable diagnosis to her condition? What are some possible causes of her condition? Should her family be worried that this condition is hereditary, and if so, what are possible prevented measures they could take to prevent this from happening to them? What statistical method did you use to determine if the condition is hereditary?

Students operate mock 3D bioprinters in order to print tissue constructs of bone, muscle and skin for a fictitious trauma patient, Bill. The model bioprinters are made from ordinary materials— cardboard, dowels, wood, spools, duct tape, zip ties and glue (constructed by the teacher or the students)—and use squeeze bags of icing to lay down tissue layers. Student groups apply what they learned about biological tissue composition and tissue engineering in the associated lesson to design and fabricate model replacement tissues. They tangibly learn about the technical aspects and challenges of 3D bioprinting technology, as well as great detail about the complex cellular composition of tissues. At activity end, teams present their prototype designs to the class.

Students further their understanding of the engineering design process while combining mechanical engineering and bioengineering to create an automated medical device. During the activity, students are given a fictional client statement and are required to follow the steps of the design process to create medical devices that help reduce the workload for hospital workers and increase the quality of patient care.

Students continue the research begun in the associated lesson as if they were biomedical engineers working for a pharmaceutical company. Groups each perform a simple chemical reaction (to precipitate solid calcium out of solution) to observe what may occur when Osteopontin levels drop in the body. With this additional research, students determine potential health complications that might arise from a new drug that could reduce inflammatory pain in many patients, improving their quality of life. The goal of this activity is to illustrate biomedical engineering as medical problem solving, as well as emphasize the importance of maintaining normal body chemistry.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The ongoing Covid-19 pandemic has highlighted the importance of streamlining regulatory approval of medical products and technologies. Computational medicine, an emerging field integrating computational imaging and modelling, offers a pathway to refine, reduce, or replace otherwise costly and lengthy clinical trials – allowing them to be performed computationally, or in-silico. But reduced cost and time are only two benefits of in-silico trials. By performing trials on virtual populations, investigators can thoroughly explore extreme but plausible conditions that would not be feasible or ethical to consider in conventional clinical trials. They can also reduce the risk of human harm and the need for animal experiments. However, because in-silico trials are a new approach, the question of whether they can genuinely first replicate, and then expand upon, conventional trial results remains..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Acting as if they are biomedical engineers, students design and print 3D prototypes of pressure sensors that measure the pressure of the eyes of people diagnosed with glaucoma. After completing the tasks within the associated lesson, students conduct research on pressure gauges, apply their understanding of radio-frequency identification (RFID) technology and its components, iterate their designs to make improvements, and use 3D software to design and print 3D prototypes. After successful 3D printing, teams present their models to their peers. If a 3D printer is not available, use alternate fabrication materials such as modeling clay, or end the activity once the designs are complete.