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Alternative autophagy: Mechanisms and roles in different diseases
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Autophagy is an important cellular recycling process that degrades misfolded proteins and damaged organelles. In typical (“canonical”) autophagy, membranes derived from the endoplasmic reticulum surround damaged materials that need to be degraded, and the proteins Atg5 and Atg7 help form specialized digestion compartments (autophagosomes), but another type of autophagy, called alternative autophagy, was recently discovered. In alternative autophagy, the membranes that envelop the damaged materials are derived from the trans-Golgi membrane, and Atg5 and Atg7 do not participate in autophagosome formation. Alternative autophagy seems to be activated primarily under conditions of cell stress, and it plays roles in many diseases, such as heart disease, neurodegenerative disease, cancer, inflammatory bowel disease, and bacterial infection..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/18/2022
Blood: The Stuff of Life
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CC BY-NC-SA
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The purpose of this lesson is to teach students about blood and its components while instilling an appreciation of its importance for survival. The lesson takes a step-by-step approach to determining the recipe for blood while introducing students to important laboratory techniques like centrifugation and microscopy, as well as some diseases of cell types found in blood. It also highlights the importance of donating blood by explaining basic physiological concepts and the blood donation procedure.

Subject:
Biology
Life Science
Material Type:
Lecture
Provider:
MIT
Provider Set:
MIT Blossoms
Author:
Melis Anahtar
Date Added:
10/31/2014
Challenges in exploring and manipulating the human skin microbiome
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The skin is the interface between the human body and the environment, and the different features in distinct skin regions, such as different temperatures, humidity levels, gland densities, and pH values, create a variety of niches that can support a diverse skin microbiome. This microbiome includes bacteria, archaea, viruses, fungi, and even mites. A healthy skin microbiome helps maintain skin homeostasis, protects against pathogens, communicates with and trains the immune system, and affects wound healing. However, the skin microbiome can be influenced by many factors, including intrinsic factors like aging and extrinsic factors like cosmetic. Recent advances in molecular biology techniques and next-generation sequencing have drastically increased our understanding of the microorganisms that live on our skin, but the microbes are often still difficult to culture and study..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
10/14/2021
A Clinical Approach to the Human Brain
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CC BY-NC-SA
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This course is designed to provide an understanding of how the human brain works in health and disease, and is intended for both the Brain and Cognitive Sciences major and the non-Brain and Cognitive Sciences major. Knowledge of how the human brain works is important for all citizens, and the lessons to be learned have enormous implications for public policy makers and educators.
The course will cover the regional anatomy of the brain and provide an introduction to the cellular function of neurons, synapses and neurotransmitters. Commonly used drugs that alter brain function can be understood through a knowledge of neurotransmitters. Along similar lines, common diseases that illustrate normal brain function will be discussed. Experimental animal studies that reveal how the brain works will be reviewed.
Throughout the seminar we will discuss clinical cases from Dr. Byrne's experience that illustrate brain function; in addition, articles from the scientific literature will be discussed in each class.

Subject:
Anatomy/Physiology
Applied Science
Biology
Health, Medicine and Nursing
Life Science
Physical Science
Psychology
Social Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Byrne, Thomas
Date Added:
09/01/2006
Discovering Medicines, Using Robots and Computers
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CC BY-NC-SA
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Scientists who are working to discover new medicines often use robots to prepare samples of cells, allowing them to test chemicals to identify those that might be used to treat diseases. Students will meet a scientist who works to identify new medicines. She created free software that ''looks'' at images of cells and determines which images show cells that have responded to the potential medicines. Students will learn about how this technology is currently enabling research to identify new antibiotics to treat tuberculosis. Students will complete hands-on activities that demonstrate how new medicines can be discovered using robots and computer software, starring the student as ''the computer.'' In the process, the students learn about experimental design, including positive and negative controls.

Subject:
Biology
Life Science
Material Type:
Lecture
Provider:
MIT
Provider Set:
MIT Blossoms
Author:
Anne Carpenter
Date Added:
05/07/2015
Essential Notes on Pathophysiology for Advanced Practice Nurses
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CC BY-NC-SA
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This text is a compilation of lecture notes from pathophysiology courses I have taught over the last ten years. The goal of the text is to equip future advanced practice nurses with knowledge of pathophysiology for common diseases and disorders they may encounter in the primary care setting.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Textbook
Provider:
East Tennessee State University
Author:
Alex Sargsyan
Date Added:
07/02/2020
Field Trials of Health Interventions: A Toolbox
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CC BY-NC
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Before new interventions can be used in disease control programmes, it is essential that they are carefully evaluated in “field trials”, which may be complex and expensive undertakings. Descriptions of the detailed procedures and methods used in trials that have been conducted in the past have generally not been published.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Textbook
Date Added:
01/01/2015
Horse Diseases
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CC BY-NC
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 Horse Diseases Grade Level: 9th - 12thSubject: Animal ScienceDuration: 3 daysDOK Level:  2SAMR Level:  Substitution Indiana Standard: AS-3.3 Identify common diseases, parasites and physiological disorders that affect animals AS-3.4 Explain the health risk of zoonotic diseases to humans and their historical significance and future implications Objective: The students will research and write a report explaining one horse disease and one horse parasite with no more than 10 grammatical errors.Procedure: Show the video Horse & Human Crossover DiseasesHold a class discussion about zoonotic diseases and if they are familiar of any other diseases like thisHave them write a short description of a zoonotic disease in their notebookHand out and explain the Horse Disease Project guidelinesUse google classroom to manage the submission of the project and progress checks.Have the students claim their disease and parasites picked for their reports under the comments of the google classroom assignment. Day 2 Have students review each other's work and make suggestionsDay 3 Have the students prepare and present a summary of their findingsProduct or Assessment: The students will be graded on the feedback they give their peers, written report, and the verbal summary. 

Subject:
Agriculture
Material Type:
Lesson Plan
Author:
Macon Beck
Date Added:
07/14/2017
An Introduction to Global Health - Epidemiological and Demographic Transition (18:46)
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CC BY-NC-ND
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This presentation provides an introduction to the principles of demographic and epidemiological transition with specific focus on how changes in life expectancy, socio-economic factors and life conditions will change the landscape of global disease burdens.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
University of Copenhagen
Provider Set:
An Introduction to Global Health
Author:
Epidemiologist Dan W. Meyrowitsch
Date Added:
01/07/2014
Macro-Microarray
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CC BY-NC-SA
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In this activity, learners explore the "nuts and bolts" of gene chips. Learners construct a simple model of a DNA microarray (also known as gene chips) and learn how microarrays can be used to identify and treat disease--including cancer. This resource includes references and an explanation of microarrays.

Subject:
Genetics
Life Science
Material Type:
Activity/Lab
Provider:
Exploratorium
Author:
Julie Yu
National Science Foundation
The Exploratorium
Date Added:
11/07/2007
Medical Terminology
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CC BY
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This course introduces nursing students to the language of the Health Sciences and medicine with emphasis on body systems, prefixes, suffixes, root terms, and spelling. Upon completion, students will be able to analyze words structurally and demonstrate a correlation of the word elements with basic anatomy, physiology, and disease processes of the body.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Full Course
Provider:
SkillsCommons
Date Added:
09/25/2017
Problem Based Module: Viruses
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CC BY-NC
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In this project, you will explore a real-world problem, and then work through a series of steps to analyze that problem, research ways the problem could be solved, then propose a possible solution to that problem. Often, there are no specific right or wrong solutions, but sometimes one particular solution may be better than others. The key is making sure you fully understand the problem, have researched some possible solutions, and have proposed the solution that you can support with information / evidence.Begin by reading the problem statement in Step 1. Take the time to review all the information provided in the statement, including exploring the websites, videos and / or articles that are linked. Then work on steps 2 through 8 to complete this problem-based learning experience.

Subject:
Biology
Life Science
Material Type:
Lesson Plan
Author:
Bonnie Waltz
Deanna Mayers
Tracy Rains
Date Added:
10/01/2017
Study design
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CC BY-NC-ND
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Epidemiological studies can be described as belonging to one of two categories: descriptive or analytical. Descriptive studies involve detailed investigations of individuals in order to improve knowledge of disease. Descriptive studies often have no prior hypotheses and are opportunistic studies of disease whereas analytical studies are used to test hypotheses by selection and comparison of groups. However, data obtained from analytical studies can be used in a descriptive manner and vice versa.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Veterinary Epidemiology
Date Added:
02/27/2015
Veterinary Epidemiology - General Concepts
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Veterinary epidemiology is principally concerned with the study of disease within populations (although it may also be used for investigation of issues such as animal welfare and productivity). Put simply, it involves the investigation of patterns of disease within a population, in relation to which animals are affected, the spatial distribution (i.e. location) of affected animals, and the temporal distribution of affected animals (i.e. patterns of disease through time).

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Veterinary Epidemiology
Date Added:
02/27/2015
Veterinary epidemiology: introduction
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The principles of veterinary epidemiology are identical to those of human epidemiology, with the exception that they are applied to animal populations rather than human populations. As such, veterinary and human epidemiology can be viewed as forms of the same overarching discipline of epidemiology. Epidemiology is principally concerned with the investigation of disease within populations (although the same principles are also applicable to investigation of other characteristics, such as animal welfare or productivity), and is based on the concept that disease often does not occur in a random fashion. That is, various characteristics of the animal, the pathogenic agent (or agents) and the environment interact in order to alter the probability of disease occurrence. Epidemiology aims to identify these factors and to describe disease in the population.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Veterinary Epidemiology
Date Added:
02/27/2015
WPA Posters: Planned Housing Fights Disease
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Public Domain
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Poster promoting planned housing as a method to deter disease in cities, showing microorganisms. New York City Housing Authority - Fiorello H. La Guardia, Mayor - Langdon W. Post, Commissoner.

Subject:
History
U.S. History
Material Type:
Diagram/Illustration
Primary Source
Provider:
Library of Congress
Provider Set:
Library of Congress - WPA Posters
Date Added:
07/31/2013