This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Heart attacks are dangerous events that lead to a massive loss of heart cells, called cardiomyocytes. The catastrophic damage can be treated by generating cardiomyocytes from stem cells and transplanting them into the heart. The stem cells can then proliferate in the space before becoming new cardiomyocytes by differentiating and maturing. But little is known about how macrophages from the injury site impact stem cell-derived cardiomyocytes. To learn more, researchers cultured these stem cells, called induced pluripotent stem cells (iPSCs), with macrophages of several subtypes. Macrophages start in a non-polarized phenotype (M0) and then can polarize between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes. The pro-inflammatory M1 phenotype macrophages were likely to be found at the injury site, and they inhibited iPSC differentiation and maturation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Mad Scientists Club - Experiments
by Olivia Taylor Copyright 2019 by Olivia Taylor under Creative Commons Non-Commercial License. Individuals and organizations may copy, reproduce, distribute, and perform this work and alter or remix this work for non-commercial purposes only.

NEBRASKA HONORS PROGRAM CLC EXPANDED LEARNING OPPORTUNITY CLUBS INFORMATION SHEET:
Name of Club: Mad Scientists

Age/Grade Level: varies; Grades 2 - 3rd and 4 - 5th

Number of Attendees: 12-15

Goal of the Club: The goal was to expand the children’s knowledge of basic science principles through demonstration and hands on experiments. Resources: University of Nebraska Lincoln Honors Program

Content Areas: (check all that apply)

☐ Arts (Visual, Music, Theater &Performance)
☐ Literacy
☒ STEM (Science, Technology, Engineering &Math)
☐ Social Studies
☐ Wellness (Physical Education, Health, Nutrition &Character Education)
Outputs or final products: The club did not have a final product, but during many of the weekly experiments we made items the children could take home to show their friends and family.

Introducing your Club/Activities: I led a science club to two groups of kids at separate times. Through experimentation I taught the kids basic natural science fundamentals. We did an experiment each week and a mini lesson to describe the experiment after.

General Directions: Each week once we got to the classroom I took attendance, introduced what we were doing that day, then performed either a demonstration or an experiment with the students. After the experiment was finished we cleaned up then I explained how and why the experiments worked the way they did.

Tips/Tricks: While working through the experiments it worked out best to perform each step with the students and all work at the same pace.

Fabrication laboratories (FabLabs) are utilized to materialize concepts. They can improve cognitive and creative abilities when used in a design-learning situation. Numerous studies have attempted to comprehend the relationship between makerspaces and creativity in a variety of disciplines, with the capacity to generate innovative consequences in makerspaces dependent on creativity. However, a comprehensive study that provides a holistic perspective on the contributions of labs as inclusive places that stimulate creativity for people with disabilities is absent. In order to address this study gap, the paper that follows provides an overview of FabLabs, makerspaces, and creativity and introduce the first of its kind MadaFabLab, as the first inclusive fablab in the world designed and tailored for innovators with disabilities “MadaFabLab”. The studies revealed that fablabs contribute to the development of creative person, product, physical, and social surroundings, as well as creative process. In addition, the MadaFabLab, a novel inclusive idea, fosters problem-solving, collaborative, and communication skills, and offers appealing locations and tools for the development of creative solutions to real-world challenges and needs identified by people with disabilities. We identified and analyzed five important themes pertaining to technical skills, technological and environmental factors, STEM learning, and skill development, and focused on their significance for fostering creativity in an inclusive FabLab.

Students are introduced to a unique fluid ferrofluids the shape of which can be influenced by magnetic fields. This activity supplements traditional magnetism activities and offers comparisons between large-scale materials and nanomaterials.Students are introduced to the concepts of magnetism, surfactants and nanotechnology by relating movie magic to practical science. Students observe ferrofluid properties as a stand-alone fluid and under an imposed magnetic field. They learn about the components of ferrofluids and their functionality as they create shapes using magnetically controlled ferrofluids and create their masterpieces.

Students watch video clips from the October Sky and Harry Potter and the Sorcerer's Stone movies to see examples of projectile motion. Then they explore the relationships between displacement, velocity and acceleration, and calculate simple projectile motion. The objective of this activity is to articulate concepts related to force and motion through direct immersive interaction based on "The Science Behind Harry Potter" theme. Students' interest is piqued by the use of popular culture in the classroom.

In this activity, students reinforce their understanding of compound machines by building a catapult. This compound machine consists of a lever and a wheel-and-axel. Catapults have been designed by engineers for a variety of purposes from lifting boulders into the air for warfare to human beings for entertainment; the projectiles in this activity are grapes for a magic act. Given the building materials, students design and build their catapult to launch a grape a certain distance.

Students complete a series of six short investigations involving magnets to learn more about their properties. Students also discuss engineering uses for magnets and brainstorm examples of magnets in use in their everyday lives.

Students visualize the magnetic field of a strong permanent magnet using a compass. The lesson begins with an analogy to the effect of the Earth's magnetic field on a compass. Students see the connection that the compass simply responds to the Earth's magnetic field since it is the closest, strongest field, and thus the compass responds to the field of the permanent magnets, allowing them the ability to map the field of that magnet in the activity. This information will be important in designing a solution to the grand challenge in activity 4 of the unit.

This lesson introduces students to the effects of magnetic fields in matter addressing permanent magnets, diamagnetism, paramagnetism, ferromagnetism, and magnetization. First students must compare the magnetic field of a solenoid to the magnetic field of a permanent magnet. Students then learn the response of diamagnetic, paramagnetic, and ferromagnetic material to a magnetic field. Now aware of the mechanism causing a solid to respond to a field, students learn how to measure the response by looking at the net magnetic moment per unit volume of the material.

Students measure the relative intensity of a magnetic field as a function of distance. They place a permanent magnet selected distances from a compass, measure the deflection, and use the gathered data to compute the relative magnetic field strength. Based on their findings, students create mathematical models and use the models to calculate the field strength at the edge of the magnet. They use the periodic table to predict magnetism. Finally, students create posters to communicate the details their findings. This activity guides students to think more deeply about magnetism and the modeling of fields while practicing data collection and analysis. An equations handout and two grading rubrics are provided.

In this fun, engaging activity, students are introduced to a unique type of fluid ferrofluids whose shape can be influenced by magnetic fields! Students act as materials engineers and create their own ferrofluids. They are challenged to make magnetic ink out of ferrofluids and test their creations to see if they work. Concurrently, they learn more about magnetism, surfactants and nanotechnology. As they observe fluid properties as a standalone-fluid and under an imposed magnetic field, they come to understand the components of ferrofluids and their functionality.

Students explore electromagnetism and engineering concepts using optimization techniques to design an efficient magnetic launcher. Groups start by algebraically solving the equations of motion for the velocity at the time when a projectile leaves a launcher. Then they test three different launchers, in which the number of coils used is different, measuring the range and comparing the three designs. Based on these observations, students record similarities and differences and hypothesize on the underling physics. They are introduced to Faraday's law and Lenz's law to explain the physics behind the launcher. Students brainstorm how these principals might be applied to real-world engineering problems.

Students begin working on the grand challenge of the unit by thinking about the nature of metals and quick, cost-effective means of separating different metals, especially steel. They arrive at the idea, with the help of input from relevant sources, to use magnets, but first they must determine if the magnets can indeed isolate only the steel.

Students learn about magnets and how they are formed. They investigate the properties of magnets and how engineers use magnets in technology. Specifically, students learn about magnetic memory storage, which is the reading and writing of data information using magnets, such as in computer hard drives, zip disks and flash drives.

This lesson ties the preceding lessons together and brings students back to the grand challenge question on MRI safety. During this lesson, students focus on the logistics of magnetic resonance imaging as well as the MRI hardware. Students can then integrate this knowledge with their acquired knowledge on magnetic fields to solve the challenge question.

Students explore the basic magnetic properties of different substances, particularly aluminum and steel. There is a common misconception that magnets attract all metals, largely due to the ubiquity of steel in metal products. The activity provides students the chance to predict, whether or not a magnet will attract specific items and then test their predictions. Ultimately, students should arrive at the conclusion that iron (and nickel if available) is the only magnetic metal.

In this activity, students will learn about the Richter Scale for measuring earthquakes. The students will make a booklet with drawings that represent each rating of the Richter Scale.

In this activity, students use their own creativity (and their bodies) to make longitudinal and transverse waves. Through the use of common items, they will investigate the different between longitudinal and transverse waves.

Students determine the refractive index of a liquid with a simple technique using a semi-circular hollow block. Then they predict the refractive index of a material (a Pyrex glass tube) by matching it with the known refractive index of a liquid using the percent light transmission measurement. The homemade light intensity detector uses an LED and multimeter, which are relatively inexpensive (and readily available) compared to commercially available measurement instruments.

Students learn about the difference between temperature and thermal energy. They build a thermometer using simple materials and develop their own scale for measuring temperature. They compare their thermometer to a commercial thermometer, and get a sense for why engineers need to understand the properties of thermal energy.