Students create large-scale models of microfluidic devices using a process similar to that of the PDMS and plasma bonding that is used in the creation of lab-on-a-chip devices. They use disposable foam plates, plastic bendable straws and gelatin dessert mix. After the molds have hardened overnight, they use plastic syringes to inject their model devices with colored fluid to test various flow rates. From what they learn, students are able to answer the challenge question presented in lesson 1 of this unit by writing individual explanation statements.

Student teams build model hand dynamometers used to measure grip strengths of people recovering from sports injuries. They use their models to measure how much force their classmates muscles are capable of producing, and analyze the data to determine factors that influence a person's grip strength. They use this information to produce a recommendation of a hand dynamometer design for a medical office specializing in physical therapy. They also consider the many other ways grip strength data is used by engineers to design everyday products.

Students calculate the viscosity of various household fluids by measuring the amount of time it takes marble or steel balls to fall given distances through the liquids. They experience what viscosity means, and also practice using algebra and unit conversions.

After conducting the associated activity, students are introduced to the material behavior of elastic solids. Engineering stress and strain are defined and their importance in designing devices and systems is explained. How engineers measure, calculate and interpret properties of elastic materials is addressed. Students calculate stress, strain and modulus of elasticity, and learn about the typical engineering stress-strain diagram (graph) of an elastic material.

Students obtain a basic understanding of microfluidic devices, how they are developed and their uses in the medical field. After conducting the associated activity, they watch a video clip and learn about flow rate and how this relates to the speed at which medicine takes effect in the body. What they learn contributes to their ongoing objective to answer the challenge question presented in lesson 1 of this unit. They conclude by solving flow rate problems provided on a worksheet.

Students use provided materials to design and build prototype artificial heart valves. Their functioning is demonstrated using water to simulate the flow of blood through the heart. Upon completion, teams demonstrate their fully functional prototypes to the rest of the class, along with a pamphlet that describes the device and how it works.

Students learn some of the implications of 3D printing in the biomedical field. Unlike 3D printers used in a classroom or by consumers, which use a plastic filament to produce a product, 3D printing for medical purposes is often with real living cells. In this lesson, students gain an understanding of how 3D printing is changing lives for the better through a presentation and group discussion. In the corresponding activity, they have the opportunity to participate in a hands-on simulation of a real-world 3D printing task.

Students are introduced to the field of biomechanics and how the muscular system produces human movement. They learn the importance of the muscular system in our daily lives, why it is important to be able to repair muscular system injuries and how engineering can help.

Students are introduced to various types of hearing impairments and the types of biomedical devices that engineers have designed to aid people with this physical disability.

Through two lessons and four activities, students learn about nanotechnology, its extreme smallness, and its vast and growing applications in our world. Embedded within the unit is a broader introduction to the field of material science and engineering and its vital role in nanotechnology advancement. Engaging mini-lab activities on ferrofluids, quantum dots and gold nanoparticles introduce students to specific fields within nanoscience and help them understand key concepts as the basis for thinking about engineering and everyday applications that use next-generation technology nanotechnology.

Students learn about the biomedical use of nanoparticles in the detection and treatment of cancer, including the use of quantum dots and lasers that heat-activate nanoparticles. They also learn about electrophoresis a laboratory procedure that uses an electric field to move tiny particles through a channel in order to separate them by size. They complete an online virtual mini-lab, with accompanying worksheet, to better understand gel electrophoresis. This prepares them for the associated activity to write draft research proposals to use nanoparticles to protect against, detect or treat skin cancer.

This lesson describes the function and components of the human nervous system. It helps students understand the purpose of our brain, spinal cord, nerves and the five senses. How the nervous system is affected during spaceflight is also discussed in this lesson.

Through this unit, students act as engineers who are given the challenge to design laparoscopic surgical tools. After learning about human anatomy and physiology of the abdominopelvic cavity, especially as it applies to laparoscopic surgery, students learn about the mechanics of elastic solids, which is the most basic level of material behavior. Then, they explore the world of fluids and learn how fluids react to forces. Next, they combine their understanding of the mechanics of solids and fluids to understand viscoelastic materials, such as those found in the human body. Finally, they learn about tissue mechanics, including how collagen, elastin and proteoglycans give body tissues their unique characteristics. In the culminating hands-on activity, student teams design their own prototypes of laparoscopic surgical robots remotely controlled, camera-toting devices that must fit through small incisions, inspect organs and tissue for disease, obtain biopsies, and monitor via ongoing wireless image-taking. They use a (homemade) synthetic abdominal cavity simulator to test and iterate the prototype devices.

Acting as biomedical engineers, students design, build, test and redesign prototype heart valves using materials such as waterproof tape, plastic tubing, flexible plastic and foam sheets, clay, wire and pipe cleaners. They test them with flowing water, representing blood moving through the heart. As students creatively practice engineering problem solving, they demonstrate their understanding of how one-way heart valves work.

This lesson covers the topic of human bones and joints. Students learn about the skeleton, the number of and types of bones in the body, and how outer space affects astronauts' bones. Students also learn how to take care of their bones here on Earth to prevent osteoporosis or weakening of the bones.

Vision is the primary sense of many animals and much is known about how vision is processed in the mammalian nervous system. One distinct property of the primary visual cortex is a highly organized pattern of sensitivity to location and orientation of objects in the visual field. But how did we learn this? An important tool is the ability to design experiments to map out the structure and response of a system such as vision. In this activity, students learn about the visual system and then conduct a model experiment to map the visual field response of a Panoptes robot. (In Greek mythology, Argus Panoptes was the "all-seeing" watchman giant with 100 eyes.) A simple activity modification enables a true black box experiment, in which students do not directly observe how the visual system is configured, and must match the input to the output in order to reconstruct the unseen system inside the box.

In a class demonstration, the teacher places different pill types ("chalk" pill, gel pill, and gel tablet) into separate glass beakers of vinegar, representing human stomach acid. After 20-30 minutes, the pills dissolve. Students observe which dissolve the fastest, and discuss the remnants of the various pills. What they learn contributes to their ongoing objective to answer the challenge question presented in lesson 1 of this unit.

Students are introduced to prosthetics history, purpose and benefits, main components, main types, materials, control methods, modern examples including modern materials used to make replacement body parts and the engineering design considerations to develop prostheses. They learn how engineers and medical doctors work together to improve the lives of people with amputations and the challenges faced when designing new prostheses with functional and cosmetic criteria and constraints. A PowerPoint(TM) presentation and two worksheets are provided.

To gain a better understanding of the roles and functions of components of the human respiratory system and our need for clean air, students construct model lungs that include a diaphragm and chest cavity. They see how air moving in and out of the lungs coincides with diaphragm movement. Then student teams design and build a prototype face mask pollution filter. They use their model lungs to evaluate their prototypes to design requirements.

Students use balloons (a polymer) to explore preconditioning a viscoelastic material behavior that is important to understand when designing biomedical devices. They improve their understanding of preconditioning by measuring the force needed to stretch a balloon to the same displacement multiple times. Students gain experience in data collection and graph interpretation.