This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Myocardial infarction (MI), or heart attack, can cause long-term damage that leads to heart failure. To treat this type of heart failure, it’s critical to heal the pathological structural changes in the heart and preserve cardiac function. A recent study investigated potential treatment targets by exploring the role of the enzyme ADAM17, whose levels are increased during MI. In a group of 152 patients with MI, high ADAM17 levels were associated with a greater incidence of subsequent heart failure, as well as poorer heart function and higher mortality, suggesting a negative role of ADAM17. In mice with MI, elevated ADAM17 levels were linked to heart damage, but blocking ADAM17 activity limited the cardiac damage and remodeling after MI. Experiments in cultured heart cells revealed that ADAM17 exerted its harmful effects by promoting loss of the cardioprotective enzyme ACE2 and that the activation of ADAM17 depended on modification of a specific site in the protein p38 MAPK..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The coral reefs of the South Pacific island nation of Vanuatu are the backbone of the island's environmental and economic health. Today they face destruction from a silent predator that can rapidly decimate an entire reef. In this video, students learn about how a starfish is destroying the coral reefs of Vanuatu and how the islanders are adapting.

In this video, an entrepreneur is finding new ways to manage the invasive Asian carp problem in the Mississippi and Ohio rivers. Once introduced to help mitigate an algae problem, the carp became invasive. This video highlights how the local community has adapted to the issue, including how they have gained ideas about how to utilize the carp from other cultures to help mitigate the issue.

This exercise should be used after you think students know what AFM diagrams are and how they work. This is sort of a quiz -- to see if they can properly interpret the diagrams. There is no point moving on to real projects that involve AFM diagrams if the students don't understand the basics.

(Note: this resource was added to OER Commons as part of a batch upload of over 2,200 records. If you notice an issue with the quality of the metadata, please let us know by using the 'report' button and we will flag it for consideration.)

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Healthy corneas are clear and lack blood vessels, but injuries like alkali burns can trigger neovascularization. This serious complication reduces the patient’s vision and is the leading cause of failure in corneal transplants. Previous studies have suggested that AIP1 (Apoptosis signal-regulating kinase 1-interacting protein) is involved in inflammatory neovascularization induction and that NOX4 (NADPH oxidase 4) is activated by alkali burns. NOX4 can produce reactive oxygen species (ROS) which unbalance the expression of the inflammation-related proteins NLRP3 and NLRP6 (NLR family pyrin domain containing 3 and 6). Researchers recently used a mouse model to examine how AIP1 and NOX4 are related to NLRP3/NLRP6 after corneal alkali burns. Corneal alkali burns decreased AIP1 expression and increased the expression of two pro-angiogenic proteins, clv-IL-1β (cleaved interleukin-1β) and VEGFa (vascular endothelial growth factor A)..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Some proteins are central to many cell signaling processes. One of these key molecules is AKT2. An important kinase involved in cell survival, growth, and metabolism, it has ties to insulin-induced signaling and cancer. AKT2 has a critical role in immune cells such as neutrophils and macrophages; however, although AKT2 is expressed in antibody-producing immune cells called B cells, its function in B cells isn’t clear. In a recent study, researchers sought to understand the role of AKT2 in B cells using AKT2-deficient mice. They found that mice lacking AKT2 had impaired B-cell differentiation. B cells from these mice were not able to form a cluster of molecules called a signalosome in response to B-cell receptor (BCR) signaling, resulting in poor BCR signaling and impaired B cell activation and spreading. These results suggest that as a central orchestrator of signaling, AKT2 function is critical for proper BCR signaling and B cell development, ensuring a functional antibody-mediated immune response..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Gq protein-coupled receptors (GqPCRs) are membrane bound proteins that transmit signals from outside the cell to internal signaling pathways. One of these pathways is the PI3K/AKT pathway, which plays roles in cellular proliferation, survival, metabolism, and differentiation. PI3K/AKT dysregulation is also often implicated in cancers. A previous study determined that activating GqPCRs in certain cells inactivated AKT, which led to a specific type of cell death, JNK-dependent apoptosis. This unique signal seems to play an important role in physiological and pathological events like pituitary development and cardiac hypertrophy. Now, a new study determined that the mechanism of this AKT inactivation relies on another signaling-related protein, PP2A. When the GqPCRs are not activated, a fraction of PP2A "c" subunit is in a dimer complex with another protein, IGBP1 and they are bound to the p85 subunit of PI3K, causing its activation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Immune checkpoints are an effective way that cancers evade the immune system, but they're not the only one. In the case of pancreatic ductal carcinoma, or PDAC, tumor fibrosis also plays an important role. To understand how fibrosis might translate to poor outcomes among patients with PDAC, researchers examined the ARF6-AMAP1 molecular pathway, which research suggests is activated during fibrosis. Findings revealed that AMAP1 correlated with elevated expression of PD-L1, a molecule that tumor cells present on their surface to elude attack by the immune system. AMAP1 was also linked to elevated fibrosis. Consistently, silencing AMAP1 in a mouse model of human PDAC reduced PD-L1 and fibrosis in their tumors. Suppressing the ARF6-AMAP1, therefore, could be one way to ensure that PDAC tumors can’t hide from immune defenses, offering the prospect of more effective immunotherapies for patients with pancreatic ductal carcinoma..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The transcription factor ATF5 plays a vital role in the formation of several cancers, including breast, lung, ovarian, pancreatic, rectal, and liver cancer. But ATF5’s function in esophageal cancer—one of the most common forms of cancer worldwide—remains unclear. To find out, researchers monitored the activity of ATF5 in esophageal cancer tissues. Much like in other cancers, ATF5 was upregulated in esophageal cancer tissues cultured in the lab, and ATF5 overexpression promoted the proliferation, migration, and invasiveness of esophageal cancer cells. Silencing ATF5, however, inhibited these abilities. In fact, in mice, silencing ATF5 hampered tumor growth. ATF5’s role as a lever that triggers tumor growth is believed to occur through an interaction with HIF1, a protein complex also known to promote the growth and spread of tumors. These findings suggest that the known anti-cancer effects of silencing ATF5 might also be powerful against esophageal cancer..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

ATP synthase and its role in mitochondria during respiration and chloroplasts during photosynthesis.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, causing diseases including chronic myelogenous and acute lymphoblastic leukemia. Drugs targeting Abl kinase activity serve as paradigms of targeted therapy. Drosophila is an ideal model for studying Abl’s function because there is only a single fly Abl family member. In flies, Abl is essential for embryonic morphogenesis, playing diverse roles in embryonic and adult viability. To examine the role of the intrinsically disordered region (IDR) of Abl, researchers deleted the IDR in Drosophila. They found that Abl lacking the IDR was not able to rescue the roles of Abl in viability and embryonic morphogenesis. The IDR was also essential for cell shape changes and cytoskeletal regulation during embryonic morphogenesis and, surprisingly, for modulating protein stability..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Selection of reading resources for Abnormal Psychology courses.
These resources were compiled by Dr. Susan Harvey, Professor at Delta College

Selection of reading resources for Abnormal Psychology courses.
These resources were compiled by Dr. Susan Harvey, Professor at Delta College

Introduction to the linguistic study of language pathology, concentrating on experimental approaches and theoretical explanations. Discussion of Specific Language Impairment, autism, Down syndrome, Williams syndrome, normal aging, Parkinson's disease, Alzheimer's disease, hemispherectomy and aphasia. Focuses on the comparison of linguistic abilities among these syndromes, while drawing clear comparisons with first and second language acquisition. Topics include the lexicon, morphology, syntax, semantics and pragmatics. Relates the lost linguistic abilities in these syndromes to properties of the brain.

Selection of reading resources for Abnormal Psychology courses.
These resources were compiled by Dr. Susan Harvey, Associate Professor at Delta College

BCC Bioscience Image Library is a media file repository of images and video clips made freely available to the public, with special attention to the needs of educators and students in the biological sciences. The resources are licensed under Creative Commons 0. This means all content is free, with no restrictions on how the material may be used, reused, adapted or modified for any purposes, without restriction under copyright or database law.

This project was partially funded by a $20,000,000 grant awarded by the U.S. Department of Labor’s Employment and Training Administration, Grant # TC-26450-14-60-A-25. The product was created by the grantee and does not necessarily reflect the official position of the U.S. Department of Labor. The U.S. Department of Labor makes no guarantees, warranties, or assurances of any kind, express or implied, with respect to such information, including any information on linked sites and including, but not limited to, accuracy of the information or its completeness, timeliness, usefulness, adequacy, continued availability, or ownership.

If you have any questions contact professor Faye Reynolds at: bioimagesoer@gmail.com

Academic Journal of Surgery (AJS) is the official scientific journal of Research Center for Improvement of Surgical Outcomes & Procedures (RCISOP) affiliated to Tehran University of Medical Sciences. AJS is an open access, peer-reviewed, and quarterly journal that considers for publication articles in all fields and specialties of surgery in English language. This journal has both online and print versions and no charges are levied for publication.

Currently, AJS is indexed and abstracted in: Citefactor, UlrichsWeb, Index Copernicus (IC), Directory of Research Journal Indexing (DRJI), Google Scholar, International Committee of Medical Journal Editors (ICMJE), Open Academic Journals Index (OAJI), Advanced Science Index (ASI), Unversal Impact Factor (UIF), Directory of Abstract Indexing for Journals (DAJI), JournalTOCs, Electronic Journal Library (EZB), Scientific Indexing Services (SIS), AcademicKeys, Research Bible, InfoBase Index, Cosmoc Impacr Factor, Scholar Steer, Magiran, and IranMedex.

AJS focuses on all fields and specialties of surgery including General Surgery, Orthopedic Surgery, Pediatric Surgery, Neurosurgery, Plastic Surgery, Cardiothoracic Surgery, Vascular Surgery, Endocrine Surgery, GI Surgery, Colorectal Surgery, Urology, Surgical Oncology, Radiology, Anaesthesia, Trauma Services, ENT, particularly about surgical practice and research. Content includes Original Articles, Systematic Review or Meta-Analysis, Review Articles, Case Reports, Letters to the Editor, Clinical Trials and Health Policy Challenge.