For students interested in studying biomechanical engineering, especially in the field of surgery, this lesson serves as an anatomy and physiology primer of the abdominopelvic cavity. Students are introduced to the abdominopelvic cavity—a region of the body that is the focus of laparoscopic surgery—as well as the benefits and drawbacks of laparoscopic surgery. Understanding the abdominopelvic environment and laparoscopic surgery is critical for biomechanical engineers who design laparoscopic surgical tools.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Some pain after a major operation is expected -- but some patients suffer more than others. More than 60% of surgical patients have moderate-to-severe postoperative pain, potentially predisposing them to persistent postsurgical pain. But who falls into which category? To better predict patients’ pain -- and thereby provide better treatment -- researchers at the University of Florida studied a large group of surgical patients to identify different pain trajectories. The team’s work published in _Anesthesiolog_y revealed five distinct patterns determined in large part by patient-specific factors such as age, sex, and psychologic features. The researchers monitored patents’ pain reports for 7 days in 360 patients recovering from a variety of different surgeries. Pain was evaluated using the [Brief Pain Inventory], which asks for a patient’s average, worst, and least pain in the last 24 hours on a scale from zero to 10..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Students examine the structure and function of the human eye, learning some amazing features about our eyes, which provide us with sight and an understanding of our surroundings. Students also learn about some common eye problems and the biomedical devices and medical procedures that resolve or help to lessen the effects of these vision deficiencies, including vision correction surgery.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"What’s the best way to measure blood pressure in surgical patients with obesity? While oscillometry using blood-pressure cuffs is the standard, in patients with obesity, these may not fit well. And oscillometry only provides intermittent information. Arterial catheters provide continuous monitoring but are invasive and can cause complications. One alternative is using a non-invasive, continuous finger cuff method. But little is known about how these various methods compare in obese patients. A new prospective study published in the journal _Anesthesiology_ has found that in patients undergoing bariatric surgery, there was better agreement between intraarterial measurement and the finger cuff than with standard cuffs for mean arterial pressure and diastolic blood pressure. And with standard cuffs, forearm measurements were superior to those on the upper arm or lower leg..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The clinical practice of anesthesia is nearly two centuries old. But today, how anesthetics suppress consciousness remains a mystery. Specifically, how do molecular-level drug effects translate into macro-level phenomena? A recent review in the journal Anesthesiology looks at how brain slice studies are helping bridge that gap in neuroscience—with recent findings increasingly pointing to the cortex as a critical center of anesthetic action. Anesthesiologists have embraced the acute brain slice method for investigating anesthetic drug effects. Brain slices enable researchers to examine drug actions in isolated, locally connected networks under highly controlled but flexible conditions. Collectively, such studies suggest that both cortical and subcortical regions of the brain, such as the midbrain and thalamus, play important roles in anesthesia, each contributing to both the level of arousal and the content of consciousness..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This is a unit plan covering the history of the surgery. It is designed to take about 35 days (50-minute class periods). This unit is based on the book, The Butchering Art: Joseph Lister’s Quest to Transform the Grisly World of Victorian Medicine by Lindsey Fitzharris. For each of the chapters, vocab activities, pre-reading activities, and reflection questions have been created. A final project is included at the end of the unit. To grade this unit, the book is chunked into Portfolios (Prologue to Chapter 4, Chapters 5-8, Chapter 9 to Epilogue), which are designed to be the formative grades. Each of these Portfolios has a Portfolio Checksheet, which is a list of assignments that must be turned in for that unit. The Portfolios can be returned to the students and used on the final project. The final project is the summative grade for the unit. Quizzes could be added to this unit to increase the number of summative grades. To make this unit easier to facilitate, I would suggest purchasing the Audio Book, along with the hardcopies to help read to the class.

Students teams use a laparoscopic surgical trainer to perform simple laparoscopic surgery tasks (dissections, sutures) using laparoscopic tools. Just like in the operating room, where the purpose is to perform surgery carefully and quickly to minimize patient trauma, students' surgery time and mistakes are observed and recorded to quantify their performances. They learn about the engineering component of surgery.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new study published in the journal Anesthesiology suggests that computer-assisted individualized hemodynamic management is a promising strategy to minimize hypotension during certain surgeries. Intraoperative hypotension is common but can increase the risk of postoperative complications. During surgery, individualized hemodynamic management can help mitigate hypotension and decrease such complications. In this strategy, clinicians use both intravenous fluids and vasopressors to maintain mean arterial pressure and blood volume near a patient’s personalized baseline. Despite its reported success, this approach requires constant monitoring and adjustment, which can be particularly challenging during complex and prolonged surgeries. Automated systems that can deliver either vasopressors or fluids have recently been developed, but a single closed-loop system that can deliver both with minimal clinician intervention isn’t yet available..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Students learn about biomedical engineering while designing, building and testing prototype surgical tools to treat cancer. Students also learn that if cancer cells are not removed quickly enough during testing, a cancerous tumor may grow exponentially and become more challenging to eliminate. Students practice iterative design as they improve their surgical tools during the activity.

Student teams create laparoscopic surgical robots designed to reduce the invasiveness of diagnosing endometriosis and investigate how the disease forms and spreads. Using a synthetic abdominal cavity simulator, students test and iterate their remotely controlled, camera-toting prototype devices, which must fit through small incisions, inspect the organs and tissue for disease, obtain biopsies, and monitor via ongoing wireless image-taking. Note: This activity is the core design project for a semester-long, three-credit high school engineering course. Refer to the associated curricular unit for preparatory lessons and activities.

During the last couple of decades two new remarkably successful principles for diabetes therapy have appeared and are now used worldwide. These are incretin based therapy and surgical therapy. These two are at some extent linked together and in this lecture we’ll provide an introduction to these two principles for diabetes therapy.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

Students learn how healthy human heart valves function and the different diseases that can affect heart valves. They also learn about devices and procedures that biomedical engineers have designed to help people with damaged or diseased heart valves. Students learn about the pros and cons of different materials and how doctors choose which engineered artificial heart valves are appropriate for certain people.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Many factors influence recovery from surgical ACL reconstruction, and defining these is key to achieving the best outcomes. While the elements linked to surgical success in adult populations are well defined, they aren’t so clear for younger patients. New research from the Hospital for Special Surgery in New York suggests that for these patients, age matters when it comes to protecting the knee. That conclusion stems from an evaluation of 324 athletes under 20 years of age who underwent ACL reconstruction following a sports injury. A key consideration when operating on this group is minimizing the risk of growth disturbances. Children and young adolescents haven’t reached skeletal maturity, which has led to the development of age-specific surgical techniques. Researchers compared several of these approaches among groups divided based on skeletal age, school age distribution, surgical technique, and graft selection. Clinical follow-up was performed for at least 2 years..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"When weight loss attempts fail, people sometimes turn to surgery. Roux-en-Y gastric bypass is a last-resort treatment that alters gut architecture to cause substantial and sustained weight loss. The surgery alters the intestinal microbiota in the patient, which affects nutrient absorption. Unfortunately, it can be difficult to separate the effects from the surgery from those of the weight loss it causes. In a recent study, researchers used a rat model of gastric bypass to measure the changes in the resident gut microbes. They compared rats after surgery to weight-matched partners that didn’t receive surgery. 16S rRNA gene sequencing and metaproteomics revealed that the overall diversity of microbes decreased following surgery. Interestingly, changes varied by location, and the proportion of certain bacteria increased while others decreased. Metabolism-related changes were also seen in the gut microbes, including changes in amino acid and bile acid metabolism..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Blood transfusions these days are generally very safe. But they can still cause serious harm with a condition called transfusion-related acute lung injury, or TRALI. TRALI is a leading cause of death related to the use of blood products. A new review in the journal Anesthesiology provides an overview of the condition and makes the case for why anesthesiologists should be on the front lines fighting it. Classically, TRALI is defined as a lung injury occurring within 6 hours of a blood transfusion. Onset can also be delayed 24 to 72 hours in critically-ill patients in the I-C-U or O-R. TRALI is not fully understood, but is frequently described as a 2-hit process. Baseline inflammation within the recipient establishes increased risk, in part due to neutrophils in the lungs..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"We eat and speak with them, but our tongues may be even more important than we think. In a condition called ankyloglossia, also known as tongue-tie, the tongue is tethered more tightly than normal to the bottom of the mouth by the lingual frenulum. While this is usually considered relatively harmless, new work from dental and sleep experts at UCLA and Stanford suggests tongue mobility is critical for proper development of the jaw and facial tissues. In the study, researchers evaluated tongue mobility in 302 patients using the Tongue Range of Motion Ratio and the Kotlow free tongue measurement. All measurements were performed in triplicate to ensure consistency and accuracy. Each participant also had dental casts made and X-rays taken to capture anatomical features of the teeth, mouth, and face. Most people had normal or only slightly diminished tongue ranges, although some had more severe restrictions..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Low blood pressure, or hypotension, is common during surgery. Because hypotensive events are associated with worse outcomes, reducing the frequency, depth, and duration of intraoperative hypotension might be a way to help patients. Commercially available hypotension prediction algorithms can help physicians prevent potentially dangerous bouts of low blood pressure. But it’s unknown how effective they are. To address this question, researchers with the Cleveland Clinic tested a prediction algorithm in a pilot randomized controlled trial. The trial found no difference in hypotension in patients using the algorithm versus unguided controls. In the trial, which included 214 non-cardiac surgical patients, about half had care from practitioners using the algorithm, which is based on arterial pressure waveform features. The algorithm provides the probability of hypotension as an index ranging from 0 to 100, with 85 serving as an alert..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Going in for surgery? It’s possible the level of pain you’ll experience during recovery is encoded in your DNA. This conclusion draws from the work of an international collaboration of researchers. By looking at the outcomes of over 1000 patients, they pinpointed factors linked to ongoing postsurgical pain. They found that one important determinant is the code of a single gene – the brain-derived neurotrophic factor, or BDNF, gene – opening new avenues for how we understand, and treat, chronic pain. Nearly all surgical patients experience some degree of postoperative pain, but it’s usually resolved as they heal. For many, however, it can last for months or even years – a condition referred to as chronic postsurgical pain. Although some elements that lead to this condition are known – nerve injury during surgery, for example, is one common cause – there’s often no easily identifiable culprit. Enter genetics..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This textbook includes basic principles of large animal surgery and anesthesia, how to apply those principles to cases and situations, and discover ways of finding answers when you don’t remember the information, are presented with cases that aren’t “textbook” and/or things don’t go as planned.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Along with preventing pain, one function of anesthesia is to keep a person from remembering unpleasant experiences. And yet, after surgery, a very small number of patients report distressing events, which can have long-term effects, including PTSD. Anesthesia usually ensures patients lack explicit memory, but implicit memories can still form. Previous studies have suggested that implicit memory formation can occur under sedation, via circuits in the amygdala. To investigate this phenomenon, researchers in Israel conducted experiments on monkeys undergoing anesthesia using two different drugs: ketamine, an NMDA receptor antagonist; and midazolam, a GABA coagonist. The team made single-cell neuron recordings on sedated animals while the animals underwent classical conditioning using tones and an aversive odor. Specifically, the monkeys were conditioned to take a deeper breath after hearing a tone, in anticipation of a noxious odor that would make them inhale less deeply..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.