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Risk signature predicts prognosis, drug resistance in patients with glioma
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Gliomas are the most common brain tumors They’re also the most aggressive, able to resist various forms of chemotherapy Part of that ability comes from cancer stem cells rare cells with the capacity to form new tumors Researchers recently set out to understand how these cells are linked to drug resistance and prognosis among patients with glioma Using data from gene atlases, they developed a so-called risk signature This signature was designed to identify genetic factors tied to an increased risk of resistance to the popular chemotherapy drug temozolomide Tests showed that the risk signature could well predict the prognosis of patients with drug-resistant gliomas with a high risk score indicating shorter survival and malignant traits The risk signature also provides new ways to classify gliomas which could help clinicians deliver targeted treatment sooner With further refinement, the signature could serve as a stand-alone biomarker for the personalized treatment of patients with glioma.."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/27/2020
The Seeds and the Soil: Roles of Tumor Heterogeneity and the Tumor Microenvironment in Cancer Metastasis
Conditional Remix & Share Permitted
CC BY-NC-SA
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Metastatic disease is responsible for the vast majority of deaths associated with cancer, yet our understanding of how metastases arise is still developing. In this course, we will introduce various concepts and models that have been proposed to explain how cancer cells disseminate from a primary tumor to distant anatomical sites. We’ll learn about the critical factors that influence cancer metastasis frontiers through analysis and discussion of relevant primary research articles, with an emphasis on mechanisms of metastasis that can be applied across different cancer types. Students will gain a broad understanding of the field of cancer metastasis, including state-of-the-art techniques that are being used to address pressing questions in the field.
This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Subject:
Applied Science
Biology
Health, Medicine and Nursing
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Lambert, Arthur
Zhang, Yun
Date Added:
09/01/2020
Stem Cells and Regenerative Medicine
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CC BY
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This presentation was developed by Martha Lopez Yrigoyen. It is intended as a flexible tool for lectures and tutorials for first year students in the Biological and Biomedical Sciences. Diagrams are also encouraged to be used by scientists, science communicators and educators.Not all slides will be useful for everyone or for every occasion. Slides can be adapted for the purpose needed. There are two main activities intended for undergraduate students to engage and deepen their knowledge in the field of stem cells. The first  activity is more general and its aim is to familiarize students with the core concepts in stem cell and regenerative medicine. The second activity is a novel and current example of how induced pluripotent stem cells are being used in cutting edge biomedical research. The two publications suggested for students to read can be swapped for other examples. Presentationislicensed under a Creative Commons Attribution License 4.0https://creativecommons.org/licenses/by/4.0/

Subject:
Biology
Genetics
Health, Medicine and Nursing
Material Type:
Module
Author:
Martha Lopez Yrigoyen
Date Added:
05/12/2019
Stem Cells and Regenerative Medicine, a focus on Induced Pluripotent …
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CC BY
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This presentation was developed by Martha Lopez Yrigoyen.
It is intended as a flexible tool for lectures and tutorials for first year students in the Biological and Biomedical Sciences. Diagrams are also encouraged to be used by scientists, science communicators and educators.

Not all slides will be useful for everyone or for every occasion. Slides can be adapted for the purpose needed.

There are two main activities intended for undergraduate students to engage and deepen their knowledge in the field of stem cells. The first activity is more general and its aim is to familiarize students with the core concepts in stem cell and regenerative medicine. The second activity is a novel and current example of how induced pluripotent stem cells are being used in cutting edge biomedical research. The two publications suggested for students to read can be swapped for other examples.

Presentation is licensed under a Creative Commons Attribution License 4.0
https://creativecommons.org/licenses/by/4.0/

Subject:
Applied Science
Biology
Genetics
Health, Medicine and Nursing
Life Science
Material Type:
Homework/Assignment
Lecture
Author:
Martha Lopez-Yrigoyen
Date Added:
05/12/2019
Tissue Culture BT375 WSU
Conditional Remix & Share Permitted
CC BY-NC
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One semester animal and plant tissue culture upper level biotechnology course designed primarily for visual instruction. Unit 1, Cells, has 7 animations and 2 videos. Unit 2, Animal TC, has 2 mandatory virtual labs and 1 mandatory biosafety training tutorial (highlighted in red), 20 videos and 8 articles. Unit 3, Plant TC, has 12 videos and 4 articles. Videos are highlighted in blue, articles in green and animations in yellow.
Smyth 2017 BT375 WSU

Subject:
Applied Science
Career and Technical Education
Material Type:
Activity/Lab
Full Course
Date Added:
05/24/2017
Transplanted stem cells help heal traumatic brain injury by reducing pyroptotic cell death
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI’s mechanism is complex, but it may involve a particular type of cell death called pyroptosis, especially among brain cells known as microglia. Mesenchymal stem cells (MSCs), such as the stem cells in umbilical cords, have recently been found to regulate pyroptosis, but it’s unclear whether transplanted MSCs could help alleviate pyroptosis after TBI. To find out, researchers recently administered human umbilical cord MSCs and the MSC-secreted protein TSG-6 into the brains of mice with induced TBI. Both the MSCs and the TSG-6 protein alleviated neurological deficits in the TBI mice. They also reduced inflammatory molecule expression and inhibited microglial pyroptosis in the cerebral cortex. The MSCs’ beneficial effects were weakened when TSG-6 expression was inhibited, confirming the importance of this molecule..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/14/2023
When Fighting Leukemia, Evolutionary History Matters
Read the Fine Print
Some Rights Reserved
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In the next few months, college students across the country will be offered the chance to save a life by swabbing cells from the insides of their cheeks and registering as a potential marrow donor with Be The Match The Give A Spit About Cancer campaign, which launched in October, helps college students organize marrow donor registry drives. The cells collected in these drives are used to figure out who might be able to donate marrow or blood stem cells to a patient with a life-threatening disease like leukemia. While ethnicity is irrelevant to most medical procedures, marrow and blood stem cell transplants are an exception to this rule.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
University of California Museum of Paleontology
Provider Set:
Understanding Evolution
Date Added:
12/01/2011