This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"RXRβ is one of three types of retinoid X receptors, which play important roles in how cells grow, differentiate, and die and might be targets for the treatment of conditions such as insulin resistance, autoimmunity, and neurodegeneration. A recent study into the physical behavior of RXRβ could bring researchers closer to that possibility. A combination of lab experiments and computer modeling revealed the unique properties of the receptor’s AB region. This region, common to this family of receptors, enables the activation of target genes. But in RXRβ, researchers found, the AB region also supports liquid-liquid phase separation a biochemical phenomenon that is fundamental to the compartmentalization of the cell. As a driver of RXRβ’s physical behavior, this capacity for phase separation could also influence the receptor’s transcriptional behavior. Understanding how could give researchers a better idea of RXRβ’s role in disease and how it might be modulated to promote human health..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Phospholipid scramblase 1 (PLSCR1) is the most studied member of its protein family and has a complex array of suggested functions. While PLSCR1 was first described as a plasma membrane protein, it has subsequently been found in other cellular compartments and implicated in numerous cellular pathways including apoptosis, intracellular trafficking of membrane proteins, and pro-inflammatory events. PLSCR1 interacts with various effectors, mediators, and regulators that then contribute to distinct cellular processes. While most PLSCR1 interactors are thought to be cell-type specific, the mechanisms of PLSCR1's regulatory functions are often shared. But not all PLSCR1 interactors are endogenous in origin; PLSCR1 also interacts with exogenous viral proteins. These interactions regulate viral uptake and spread in both pro- and anti-viral ways..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This article describes the principle of Universal Design for Learning and how teachers can use this principle when designing lessons.

We designed this project to help Special Education students think about and experiment, and express what art means to them.There are no specific standards that we are going to use since they all will be different and flexible for each student depending on their IEP and their related services.

Students will review the signs for emotions and play a game to better understand how to use the emotions in conversation. Students will have the opportunity to communicate with peers to defend and explain their choices.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The hormone and receptor pair IGF-1 and IGF-1R and the Hippo-YAP signaling pathway are critical to breast cancer stem cells, but if or how these pathways interact in these cells remained unclear. So, researchers recently examined YAP and IGF-1R in triple negative breast cancer cell lines and xenograft models. YAP knockdown reduced viability and stemness in cell culture and tumorigenicity in vivo, suggesting that YAP contributes to stemness in breast cancer cells. Further tests determined that IGF-1R regulated YAP expression, and in turn, YAP regulated IGF-1 expression but not IGF-1R. Specifically, depleting IGF-1R decreased YAP expression, while addition of IGF-1 upregulated YAP and increased its nuclear localization. YAP overexpression increased IGF-1 expression without impacting IGF-1R expression. In clinical data from basal-like breast cancer patients, higher levels of YAP and IGF-1 are correlated with shorter overall survival..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.