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Blood: The Stuff of Life
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The purpose of this lesson is to teach students about blood and its components while instilling an appreciation of its importance for survival. The lesson takes a step-by-step approach to determining the recipe for blood while introducing students to important laboratory techniques like centrifugation and microscopy, as well as some diseases of cell types found in blood. It also highlights the importance of donating blood by explaining basic physiological concepts and the blood donation procedure.

Subject:
Biology
Life Science
Material Type:
Lecture
Provider:
MIT
Provider Set:
MIT Blossoms
Author:
Melis Anahtar
Date Added:
10/31/2014
Body Circulation
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Educational Use
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Students are introduced to the circulatory system, the heart, and blood flow in the human body. Through guided pre-reading, during-reading and post-reading activities, students learn about the circulatory system's parts, functions and disorders, as well as engineering medical solutions. By cultivating literacy practices as presented in this lesson, students can improve their scientific and technological literacy.

Subject:
Applied Science
Engineering
Life Science
Technology
Material Type:
Activity/Lab
Lesson Plan
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Denise W. Carlson
Jay Shah
Malinda Schaefer Zarske
Todd Curtis
Date Added:
09/18/2014
CAII helps tumor endothelial cells survive in a lactic acid-rich environment
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Cancer cell growth depends on the production of new blood vessels by tumor endothelial cells in a process called angiogenesis. But the growing cancer cells produce large amounts of lactic acid as a byproduct of glucose breakdown. How tumor endothelial cells are able to survive in this toxic environment is unclear. In a recent study, researchers sought to uncover the mechanism of tumor endothelial cell survival in a lactic acid-rich tumor microenvironment. Using genetics and proteomics, they compared the RNA and protein levels of pH-regulating proteins in tumor endothelial cells to those in normal endothelial cells. They found that carbonic anhydrase 2 (CAII), an important pH regulator, was elevated in tumor endothelial cells, which was induced through the VEGF signaling pathway. Blocking CAII in tumor endothelial cells decreased cell survival in lactic acid conditions, and treating tumor-bearing mice with a CAII inhibitor had decreased lung metastasis..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
10/29/2020
The Cardiovascular System : Composition of Blood (13:02)
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We take a look at the basic composition of blood. Blood is composed of liquids and solids. The solids are called the formed elements while the liquid portion is called plasma. The solids of the blood consists of red blood cells, white blood cells and platelets . The plasma is mostly water, but it does contain some plasma proteins, dissolved gases, nutrients and electrolytes.

Lesson 2 in our Cardiovascular System (Blood) series. This is part of our Anatomy and Physiology lecture series.

If this video helps you please be sure to LST -like subscribe and tell your friends. Your support helps us make more videos. For the complete series please visit http://mrfordsclass.net/

Blood Videos
-Introduction to Blood (13:01): http://youtu.be/-Y5U49E-CM4
-Composition of Blood (13:02): http://youtu.be/YHCIMKZ0zrg
-Hematopoiesis-Making Blood (13:03): http://youtu.be/sibrcrXHJGI
-Red Blood Cells (13:04): http://youtu.be/19_6kUCVYfk

Heart and Blood Vessels Videos
-Heart Fundamentals (14:01): http://youtu.be/Y335KJ-EuDw
-Layers of the Heart (14:02): http://youtu.be/8PlwFTwJRMQ
-Chambers in the Heart (14:03): http://youtu.be/SdNQtPzUfHg
-Introduction to Blood Vessels (14:08): http://youtu.be/GVs8cd6jv94
-Types of Blood Vessels (14:09): http://youtu.be/_jkQR8v-bAg
-Movement of Blood (14:11): http://youtu.be/x9dH5TpKntk

Subject:
Anatomy/Physiology
Life Science
Material Type:
Lecture
Provider:
Mr. Ford's Class
Author:
Scott Ford
Date Added:
10/05/2014
The Cardiovascular System : Hematopoiesis - Making Blood (13:03)
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In this video take a look at hematopoiesis (haematopoiesis), or the creation of blood. While we are still embryos the formation of blood can occur in multiple sites. After birth production primary takes place in red bone marrow.

All blood cells that are circulating derive from pluripotential hematopoietic cells also known as hematopoietic stem cells (HSCs). These stem cells can form any of the blood cells or other stem cells. Hematopoietic Growth Factor will help determine what the stem cell grows into.

There are three families that blood cells can grow up to become: 1) Erythroid cells, 2) Lymphocytes, and 3) Myelocytes.

Lesson 3 in our Cardiovascular System (Blood) series. This is part of our Anatomy and Physiology lecture series.

If this video helps you please be sure to LST -like subscribe and tell your friends. Your support helps us make more videos. For the complete series please visit http://mrfordsclass.net/

Blood Videos
-Introduction to Blood (13:01): http://youtu.be/-Y5U49E-CM4
-Composition of Blood (13:02): http://youtu.be/YHCIMKZ0zrg
-Hematopoiesis-Making Blood (13:03): http://youtu.be/sibrcrXHJGI
-Red Blood Cells (13:04): http://youtu.be/19_6kUCVYfk

Heart and Blood Vessels Videos
-Heart Fundamentals (14:01): http://youtu.be/Y335KJ-EuDw
-Layers of the Heart (14:02): http://youtu.be/8PlwFTwJRMQ
-Chambers in the Heart (14:03): http://youtu.be/SdNQtPzUfHg
-Introduction to Blood Vessels (14:08): http://youtu.be/GVs8cd6jv94
-Types of Blood Vessels (14:09): http://youtu.be/_jkQR8v-bAg
-Movement of Blood (14:11): http://youtu.be/x9dH5TpKntk

Subject:
Anatomy/Physiology
Life Science
Material Type:
Lecture
Provider:
Mr. Ford's Class
Author:
Scott Ford
Date Added:
10/05/2014
The Cardiovascular System : Introduction to Blood (13:01)
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In this anatomy physiology video we take a look at the functions of blood and the general composition of blood.

Lesson 1 in our Cardiovascular System (Blood) series. This is part of our Anatomy and Physiology lecture series.

If this video helps you please be sure to LST -like subscribe and tell your friends. Your support helps us make more videos. For the complete series please visit http://mrfordsclass.net/

Blood Videos
-Introduction to Blood (13:01): http://youtu.be/-Y5U49E-CM4
-Composition of Blood (13:02): http://youtu.be/YHCIMKZ0zrg
-Hematopoiesis-Making Blood (13:03): http://youtu.be/sibrcrXHJGI
-Red Blood Cells (13:04): http://youtu.be/19_6kUCVYfk

Heart and Blood Vessels Videos
-Heart Fundamentals (14:01): http://youtu.be/Y335KJ-EuDw
-Layers of the Heart (14:02): http://youtu.be/8PlwFTwJRMQ
-Chambers in the Heart (14:03): http://youtu.be/SdNQtPzUfHg
-Introduction to Blood Vessels (14:08): http://youtu.be/GVs8cd6jv94
-Types of Blood Vessels (14:09): http://youtu.be/_jkQR8v-bAg
-Movement of Blood (14:11): http://youtu.be/x9dH5TpKntk

Subject:
Anatomy/Physiology
Life Science
Material Type:
Lecture
Provider:
Mr. Ford's Class
Author:
Scott Ford
Date Added:
10/05/2014
The Cardiovascular System : Red Blood Cells (13:04)
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Red Blood Cells also known as red blood cells (RBCs) or erythrocytes are around 7.5μm in diameter. The average number (red blood cell count) is typically:
*5,200,000 per cubic millimeter ± 300,000 men
*4,700,000 per cubic millimeter ± 300,000 women

Red blood cells are made of hemoglobin. When the hemoglobin combines with oxygen it is called oxyhemoglobin, when oxygen has been released it is known as deoxyhemoglobin. The RBC initially have a nuclei during the early stages of development, they then remove the nuclei to help make room for hemoglobin.

Lesson 4 in our Cardiovascular System (Blood) series. This is part of our Anatomy and Physiology lecture series.

If this video helps you please be sure to LST -like subscribe and tell your friends. Your support helps us make more videos. For the complete series please visit http://mrfordsclass.net/

Blood Videos
-Introduction to Blood (13:01): http://youtu.be/-Y5U49E-CM4
-Composition of Blood (13:02): http://youtu.be/YHCIMKZ0zrg
-Hematopoiesis-Making Blood (13:03): http://youtu.be/sibrcrXHJGI
-Red Blood Cells (13:04): http://youtu.be/19_6kUCVYfk

Heart and Blood Vessels Videos
-Heart Fundamentals (14:01): http://youtu.be/Y335KJ-EuDw
-Layers of the Heart (14:02): http://youtu.be/8PlwFTwJRMQ
-Chambers in the Heart (14:03): http://youtu.be/SdNQtPzUfHg
-Introduction to Blood Vessels (14:08): http://youtu.be/GVs8cd6jv94
-Types of Blood Vessels (14:09): http://youtu.be/_jkQR8v-bAg
-Movement of Blood (14:11): http://youtu.be/x9dH5TpKntk

Subject:
Anatomy/Physiology
Life Science
Material Type:
Lecture
Provider:
Mr. Ford's Class
Author:
Scott Ford
Date Added:
10/05/2014
Catching lung cancer early using only a sample of blood
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Lung cancer is the number one cause of cancer-related death Early detection is key to beating the disease A lung tumour that’s detected early, before it grows too large or spreads to other parts of the body, can be removed by surgeons and essentially cured The problem is that early detection is tricky Most patients don’t develop symptoms until advanced disease has set in, and the most common screening methods can be expensive and impractical Scientists are working on a new blood test that could help The test can spot small bits of DNA floating around in the blood Cancer cells shed this DNA as they grow and multiply Preliminary tests in mice showed the test can detect lung tumours before they become malignant The amount of tumour DNA found in the blood went up as tumours grew, giving scientists an idea of how large a mass had become More work is needed before the test can be used to detect cancer in humans But the research suggests that spotting early-stage lung cancer may one day be.."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019
Coagulation Tests
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It is important that all aspects of haemostasis can be independently evaluated. This will help to identify the phase affected and to pinpoint what the abnormality is. There are tests available to assess primary haemostasis, secondary haemostasis and fibrinolysis.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Blood
Date Added:
02/11/2015
Complement
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Complement is so called because it complements the function of antibody. It is a triggered enzyme cascade and there are more than 20 different proteins in the complement cascades, with most being enzymes or pro-enzymes. It can be activated by both the innate and adaptive immune systems and is one of the main innate protective mechanisms of invertebrates. Due to its destructive potential the complement system is heavily regulated but when activated it works largely by forming pore complexes as well as triggering acute inflammation and by promoting phagocytosis by macrophages and neutrophils.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Blood
Date Added:
02/11/2015
Diseases Exposed: ESR Test in the Classroom
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Educational Use
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Students demonstrate the erythrocyte sedimentation rate test (ESR test) using a blood model composed of tomato juice, petroleum jelly and olive oil. They simulate different disease conditions, including rheumatoid arthritis, anemia, leukocytosis and sickle-cell anemia, by making appropriate variations in the particle as well as in the fluid matrix. Students measure the ESR for each sample blood model, correlate the ESR values with disease conditions and confirm that diseases alter blood composition and properties. During the activity, students learn that when non-coagulated blood is let to stand in a tube, the red blood cells separate and fall to the bottom of the tube, resulting in a sediment and a clear liquid called serum. The height in millimeters of the clear liquid on top of the sediment in a time period of one hour is taken as the sedimentation rate. If a disease is present, this ESR value deviates from the normal, disease-free value. Different diseases cause different ESR values because blood composition and properties, such as density and viscosity, are altered differently by different diseases. Thus, the ESR test serves as a real-world diagnostic screening test to identify indications of the presence of any diseases in people.

Subject:
Career and Technical Education
Chemistry
Physical Science
Physics
Material Type:
Activity/Lab
Provider:
TeachEngineering
Author:
Renuka Rajasekaran
Date Added:
02/03/2017
Eosinophils
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Eosinophils are a similar size to neutrophils, have a bilobed nucleus and are characterised by the large eosinophilic granules present in their cytoplasm. Produced in the bone marrow they migrate into circulation briefly before moving into tissue where they survive for around six hours. The proportion of eosinophils circulating depends on the state of the animal. Normally numbers are very low but will rise considerably during a parasitic infection or allergic reaction.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Blood
Date Added:
02/11/2015
Erythrocytes
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Also known as red blood cells (RBCs). Erythrocytes deliver oxygen to, and remove carbon dioxide from tissues. Erythrocytes are derived from the stem cell (CFU-GEMM) and formed in a process known as erythropoiesis.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Blood
Date Added:
02/11/2015
Erythropoiesis
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Erythrocytes contain no nucleus and are thus only produced from stem cells. During the fetal stage production is in both the liver and spleen however production is transferred to the bone marrow (red marrow) in the final stages of gestation. Initially erythropoiesis occurs in all bones, however after puberty production is limited to membranous bones (ribs, vertebrae, pelvic bones etc.) as the long bones contain adipose tissue in place of red marrow.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Blood
Date Added:
02/11/2015
Examining cell-to-cell contacts to predict the efficacy of CAR immunotherapy
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Chimeric Antigen Receptor (CAR) immunotherapy is a promising new technique for precisely targeting tumor cells. The technique works by using the patient's own cells to express a molecule that combines tumor antigen specificity with immune cell activation. Doctors have already had some success treating many types of refractory blood cancers. Unfortunately, conventional tools are limited when it comes to evaluating the efficacy and safety of CAR treatment, and the potential for high toxicity makes it critical to identify patients who will benefit from the treatment. To address this, researchers have developed a new method of predicting the efficacy and toxicity of CAR immunotherapy. The Synapse Predicts Efficacy (SPE) system begins by measuring the contact site between immune cells and tumor cells – the immunological synapse. The system relies on microscopic measurements of immunological synapse quality – particularly effective polarization of the immune cell to the antigen..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
11/11/2020
Exploring the microbiome of kissing bugs
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The blood-feeding kissing bugs are the vector for Trypansoma cruzi, the parasite that causes Chagas disease in humans. One factor believed to alter parasite transmission is the kissing bug’s microbiome, which is a fundamental component of natural gut environment where T.cruzi develops. To explore this complex environment, researchers set out to identify the factors that shape the kissing bug's microbiome. They investigated the microbiome composition of 5 species of kissing bugs from two U.S. states across all life stages. They analysed 170 T. cruzi negative kissing bugs sampled from the nests of white-throated woodrats. The primary factors determining microbiome structure were developmental stage, species identity, and environment. Later developmental stages correlated with lower microbial diversity. In fact, adult microbiomes were frequently dominated by a single taxon of bacteria..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
11/12/2020
Failure of Passive Transfer
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Transfer of passive immunity in the bovine neonate occurs solely through maternal colostrum. This is in contrast to humans where placental transfer of immunity via specific Fc receptors is the predominant mechanism. However, inadequate transfer of immunity is a relatively commonly diagnosed problem affecting young stock. This is particularly the case in modern Holstein dairy herds, where large milk yields dilute the antibody concentration in the colostrum meaning relatively more must be consumed to have the same immunity transferred. Due to the lower yields and possibly other genetic reasons, this tends to be less of a problem in suckler herds.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Blood
Date Added:
02/11/2015
Haematopoiesis - Overview
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Haematopoiesis is also known as haemopoiesis or hemopoiesis and describes the process of blood cell formation. All blood cells are derived from the initial pluripotent stem cell (PPSC) which gives rise to colony forming units (CFUs). These CFUs further differentiate to give rise to their final stage of development where they become the various forms of blood cells or those cells which migrate from the circulation into tissues, such as mast cells and macrophages.

Subject:
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
WikiVet
Provider Set:
Blood
Date Added:
02/11/2015