This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Gastric cancer remains difficult to treat, but a better understanding of its mechanism might lead to better therapies. An inflammatory state characterized by neutrophil activity is known to promote gastric cancer progression. However, it’s unclear how neutrophil extracellular traps (NETs) in the tumor immune microenvironment influence tumor growth. To learn more, researchers recently analyzed NET formation in gastric cancer. Serum NET markers were elevated in patients with gastric cancer, and higher NET marker levels were associated with worse survival. In addition, more NETs formed in gastric cancer tissues than in adjacent normal tissues. In vitro, a hypoxic environment (like that in tumors) caused gastric cancer cells to release neutrophil-recruiting factors. Hypoxia also triggered the cytoplasmic translocation of HMGB1 in gastric cancer cells and subsequent HMGB1 release. This extracellular HMGB1 then activated the TLR4/p38 MAPK pathway in neutrophils to induce NET formation..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 05/08/2023
