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COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time
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Discrepancies between pre-specified and reported outcomes are an important source of bias in trials. Despite legislation, guidelines and public commitments on correct reporting from journals, outcome misreporting continues to be prevalent. We aimed to document the extent of misreporting, establish whether it was possible to publish correction letters on all misreported trials as they were published, and monitor responses from editors and trialists to understand why outcome misreporting persists despite public commitments to address it. Methods We identified five high-impact journals endorsing Consolidated Standards of Reporting Trials (CONSORT) (New England Journal of Medicine, The Lancet, Journal of the American Medical Association, British Medical Journal, and Annals of Internal Medicine) and assessed all trials over a six-week period to identify every correctly and incorrectly reported outcome, comparing published reports against published protocols or registry entries, using CONSORT as the gold standard. A correction letter describing all discrepancies was submitted to the journal for all misreported trials, and detailed coding sheets were shared publicly. The proportion of letters published and delay to publication were assessed over 12 months of follow-up. Correspondence received from journals and authors was documented and themes were extracted. Results Sixty-seven trials were assessed in total. Outcome reporting was poor overall and there was wide variation between journals on pre-specified primary outcomes (mean 76% correctly reported, journal range 25–96%), secondary outcomes (mean 55%, range 31–72%), and number of undeclared additional outcomes per trial (mean 5.4, range 2.9–8.3). Fifty-eight trials had discrepancies requiring a correction letter (87%, journal range 67–100%). Twenty-three letters were published (40%) with extensive variation between journals (range 0–100%). Where letters were published, there were delays (median 99 days, range 0–257 days). Twenty-nine studies had a pre-trial protocol publicly available (43%, range 0–86%). Qualitative analysis demonstrated extensive misunderstandings among journal editors about correct outcome reporting and CONSORT. Some journals did not engage positively when provided correspondence that identified misreporting; we identified possible breaches of ethics and publishing guidelines. Conclusions All five journals were listed as endorsing CONSORT, but all exhibited extensive breaches of this guidance, and most rejected correction letters documenting shortcomings. Readers are likely to be misled by this discrepancy. We discuss the advantages of prospective methodology research sharing all data openly and pro-actively in real time as feedback on critiqued studies. This is the first empirical study of major academic journals’ willingness to publish a cohort of comparable and objective correction letters on misreported high-impact studies. Suggested improvements include changes to correspondence processes at journals, alternatives for indexed post-publication peer review, changes to CONSORT’s mechanisms for enforcement, and novel strategies for research on methods and reporting.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Reading
Provider:
Trials
Author:
Aaron Dale
Anna Powell-Smith
Ben Goldacre
Carl Heneghan
Cicely Marston
Eirion Slade
Henry Drysdale
Ioan Milosevic
Kamal R. Mahtani
Philip Hartley
Date Added:
08/07/2020
CONEWAGO VALLEY SCHOOL DISTRICT'S INTRODUCTION TO OER - Part I Remix
Conditional Remix & Share Permitted
CC BY-NC-SA
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As Conewago Valley School District advances its open educational resource (OER) adoption and implementation plan, Leveraging its teaching and learning network and digital library, OER Commons (oercommons.org) launched in 2007.

This is the first of three custom module trainings that will provide participants with an introduction to OER practice and the value add, highlighting successful state and district use cases. Followed by a demonstration and discussion of how to navigate OER Commons and create collaborative workflows to identify resources, assess their quality using rubrics, and organize materials for use. Participants will get an opportunity to practice using OER tools and begin to design their plans for OER implementation, specific to their immediate OER needs. An important outcome for educators will be a shared understanding of OER practice and specific next steps for OER adoption in their work.

We have designed these modules to first spark the learner's interest in the topics covered and then dig deeper into the content through presentations, storytelling, and demonstrations of the tools. We will offer opportunities for learners to practice exploring the resources and tools, and reflect on how they might use them in their work.

Subject:
Education
Material Type:
Module
Date Added:
11/13/2017
Conewago
Conditional Remix & Share Permitted
CC BY-NC-SA
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As Conewago Valley School District advances its open educational resource (OER) adoption and implementation plan, OER Commons (https://oercommons.org) provides an OER toolset and immersive professional learning program to assist educators in enhancing their capacities to use, evaluate, curate, and create OER. Leveraging its teaching and learning network and digital library, OER Commons (oercommons.org) launched in 2007, ISKME advances collaboration and continuous improvement of high-quality curriculum.

Participants will get an opportunity to practice using OER tools and begin to design their plans for OER implementation, specific to their immediate OER needs. An important outcome for educators will be a shared understanding of OER practice and specific next steps for OER adoption in their work.

We will offer opportunities for learners to practice exploring the resources and tools, and reflect on how they might use them in their work.

Subject:
Education
Material Type:
Module
Date Added:
10/17/2017
Conewago
Conditional Remix & Share Permitted
CC BY-NC-SA
Rating
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As Conewago Valley School District advances its open educational resource (OER) adoption and implementation plan, Leveraging its teaching and learning network and digital library, OER Commons (oercommons.org) launched in 2007. This is the third of three custom module trainings that will provide participants with an introduction to OER practice and the value add, highlighting successful state and district use cases. Followed by a demonstration and discussion of how to navigate OER Commons and create collaborative workflows to identify resources, assess their quality using rubrics, and organize materials for use. Participants will get an opportunity to practice using OER tools and begin to design their plans for OER implementation, specific to their immediate OER needs. An important outcome for educators will be a shared understanding of OER practice and specific next steps for OER adoption in their work. We have designed these modules to first spark the learner's interest in the topics covered and then dig deeper into the content through presentations, storytelling, and demonstrations of the tools. We will offer opportunities for learners to practice exploring the resources and tools, and reflect on how they might use them in their work.

Subject:
Education
Material Type:
Module
Date Added:
11/16/2017
Elementary Earth and Space Science Methods
Conditional Remix & Share Permitted
CC BY-NC-SA
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This book is intended for use by future teachers, written from the perspective of students who have taken Science Methods II. The student authors gathered and created resources to help prospective elementary cience teachers better understand science and feel confident in your abilities as a future teacher.
This book is divided into five parts which align with the Science Methods II course:

Physics
Space Science
Earth Science
Climate Science
Course Materials and Pedagogy

Within each part, the material is broken down into smaller chapters. Here you will find written explanations, video links, glossary terms, key takeaways, and practice quizzes to help you understand the material. This book is designed to be a flexible resource; use it as much or as little as you need throughout the course.

Subject:
Education
Elementary Education
Higher Education
Material Type:
Teaching/Learning Strategy
Textbook
Provider:
University of Iowa
Provider Set:
Iowa Research Online
Author:
Ben Smith
Ella McDonald
Jenny Haley
Rachel Dunn
Ted Neal
Date Added:
01/05/2021