This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"RNF43 is an enzyme frequently mutated in many forms of cancer. Under normal circumstances, the protein is known to inhibit canonical Wnt signaling, which regulates various aspects of cell development and disease. What remains controversial, however, is the function of a part of the protein known as the “protease-associated” (PA) domain. To find out, researchers recorded the effects of RNF43 without this domain in human cells. They discovered that the PA domain is not essential for RNF43 to block Wnt signaling. Rather, the PA domain’s job is to regulate levels of RNF43 on the cell surface, which is achieved through the pro-Wnt protein RSPO1. Understanding how RSPO1 behaves when RNF43 lacks its PA domain could be informative, as it could refine the perceived role of RNF43 mutations in human disease..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

By the end of this section, you will be able to:Describe the difference between the central and peripheral nervous systemsExplain the difference between the somatic and autonomic nervous systemsDifferentiate between the sympathetic and parasympathetic divisions of the autonomic nervous system

Psychology is designed to meet scope and sequence requirements for the single-semester introduction to psychology course. The book offers a comprehensive treatment of core concepts, grounded in both classic studies and current and emerging research. The text also includes coverage of the DSM-5 in examinations of psychological disorders. Psychology incorporates discussions that reflect the diversity within the discipline, as well as the diversity of cultures and communities across the globe.Senior Contributing AuthorsRose M. Spielman, Formerly of Quinnipiac UniversityContributing AuthorsKathryn Dumper, Bainbridge State CollegeWilliam Jenkins, Mercer UniversityArlene Lacombe, Saint Joseph's UniversityMarilyn Lovett, Livingstone CollegeMarion Perlmutter, University of Michigan

By the end of this section, you will be able to:Describe the difference between the central and peripheral nervous systemsExplain the difference between the somatic and autonomic nervous systemsDifferentiate between the sympathetic and parasympathetic divisions of the autonomic nervous system

By the end of this section, you will be able to:Describe how hunger and eating are regulatedDifferentiate between levels of overweight and obesity and the associated health consequencesExplain the health consequences resulting from anorexia and bulimia nervosa

By the end of this section, you will be able to:Understand what is meant by consciousnessExplain how circadian rhythms are involved in regulating the sleep-wake cycle, and how circadian cycles can be disruptedDiscuss the concept of sleep debt

Thermoregulation is the ability of an endothermic organism to maintain a relatively constant body temperature, despite fluctuations in temperature of the external environment. This is a vital part of homeostasis.

Students learn about homeostasis and create models by constructing simple feedback systems using Arduino boards, temperature sensors, LEDs and Arduino code. Starting with pre-written code, students instruct LEDs to activate in response to the sensor detecting a certain temperature range. They determine appropriate temperature ranges and alter the code accordingly. When the temperature range is exceeded, a fan is engaged in order to achieve a cooling effect. In this way, the principle of homeostasis is demonstrated. To conclude, students write summary paragraphs relating their models to biological homeostasis.