This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Bariatric surgeries like gastric bypass are often used for weight loss, but they can also help protect patients from fatal heart attacks, possibly by altering the levels of gut-derived metabolic hormones like GLP-1, leptin, ghrelin, and insulin, which are known to affect heart tissue, or by acting on heart tissue directly. Researchers recently investigated the mechanisms by performing three common bariatric surgeries on non-obese, non-diabetic rats. Ten weeks later, the researchers subjected the rats to simulated heart attacks by restricting and reestablishing their cardiac blood flow. Both Roux-en-Y gastric bypass and sleeve gastrectomy, but not ileal transposition surgery, reduced the size of the damaged area in the heart and the no-reflow area to which blood flow couldn’t be restored. Gastric bypass and sleeve gastrectomy also increased GLP-1 and leptin levels, while sleeve gastrectomy reduced ghrelin levels. In contrast, none of the surgeries affected insulin levels..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

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