This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Heart attacks are dangerous events that lead to a massive loss of heart cells, called cardiomyocytes. The catastrophic damage can be treated by generating cardiomyocytes from stem cells and transplanting them into the heart. The stem cells can then proliferate in the space before becoming new cardiomyocytes by differentiating and maturing. But little is known about how macrophages from the injury site impact stem cell-derived cardiomyocytes. To learn more, researchers cultured these stem cells, called induced pluripotent stem cells (iPSCs), with macrophages of several subtypes. Macrophages start in a non-polarized phenotype (M0) and then can polarize between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes. The pro-inflammatory M1 phenotype macrophages were likely to be found at the injury site, and they inhibited iPSC differentiation and maturation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This presentation was developed by Martha Lopez Yrigoyen. It is intended as a flexible tool for lectures and tutorials for first year students in the Biological and Biomedical Sciences. Diagrams are also encouraged to be used by scientists, science communicators and educators.Not all slides will be useful for everyone or for every occasion. Slides can be adapted for the purpose needed. There are two main activities intended for undergraduate students to engage and deepen their knowledge in the field of stem cells. The first  activity is more general and its aim is to familiarize students with the core concepts in stem cell and regenerative medicine. The second activity is a novel and current example of how induced pluripotent stem cells are being used in cutting edge biomedical research. The two publications suggested for students to read can be swapped for other examples. Presentationislicensed under a Creative Commons Attribution License 4.0https://creativecommons.org/licenses/by/4.0/

This presentation was developed by Martha Lopez Yrigoyen.
It is intended as a flexible tool for lectures and tutorials for first year students in the Biological and Biomedical Sciences. Diagrams are also encouraged to be used by scientists, science communicators and educators.

Not all slides will be useful for everyone or for every occasion. Slides can be adapted for the purpose needed.

There are two main activities intended for undergraduate students to engage and deepen their knowledge in the field of stem cells. The first activity is more general and its aim is to familiarize students with the core concepts in stem cell and regenerative medicine. The second activity is a novel and current example of how induced pluripotent stem cells are being used in cutting edge biomedical research. The two publications suggested for students to read can be swapped for other examples.

Presentation is licensed under a Creative Commons Attribution License 4.0
https://creativecommons.org/licenses/by/4.0/