This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Tetramates are bioactive natural products that feature a pyrrolidine-2,4-dione ring. Approximately 14% of sequenced strains of Streptococcus mutans, a causative agent of human dental caries, bear the muc biosynthetic gene cluster (BGC) to produce mutanocyclin (MUC). MUC is a tetramate that inhibits leukocyte activity, which protects S. mutans from the host’s immune attacks. Some S. mutans strains can also accumulate the intermediates of MUC biosynthesis called reutericyclins (RTCs), which have antibacterial activity. A recent study revealed that the feature ring in MUC is closed via lactam bond formation. This contrasts with most other tetramates, which form their rings via Dieckmann cyclization. It was found that RTC is converted to MUC via the deacylase MucF. Distribution analysis revealed that BCGs like muc are widespread in human-associated bacteria..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 05/08/2023
