This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Chronic brain hypoperfusion (CBH) is caused by decreased blood flow to the brain and is considered a key predictor of neurodegenerative diseases such as Alzheimer’s disease and vascular dementia. CBH can indirectly lead to cognitive decline by altering the expression of proteins at synapses, where neurons communicate through neurotransmitters released from presynaptic vesicles and recognized by postsynaptic receptors. Researchers recently linked this decline to the microRNA miRNA-153. FM 1-43 experiments showed that overexpression of miRNA-153 impairs presynaptic vesicle release, and in a CBH rat model, overexpression of miRNA-153 decreased the expression of multiple proteins involved in vesicle release. Conversely, knockdown of miRNA-153 rescued these synaptic defects and attenuated cognitive decline in the rat model..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

We asked people diagnosed with Alzheimer's to tell us memories they never want to forget.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Micro-RNAs are small, non-coding molecules no bigger than a couple dozen nucleotides in length. But don’t let their size fool you. While they may not code for proteins, themselves, these molecules play an important role in many biological processes by regulating the expression of genes. Recently, they have been implicated in neuron development and neurodegenerative diseases such as Alzheimer’s. Now, a recent study published in the journal, _Molecular Neurodegeneration_, has identified a previously unreported association between the amount of a particular microRNA and the accumulation of toxic proteins that characterizes Alzheimer’s disease. Late-onset Alzheimer’s is characterized by structural changes in the brain and a decline in cognitive abilities, such as memory loss, that worsens with age. Despite the high prevalence of this disease and research efforts, its precise causes are still being worked out. Recent research, though, suggests altered gene expression by non-coding RNAs may play a role..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.