This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Wet age-related macular degeneration, or wet AMD, occurs when newly formed blood vessels leak or bleed into the center of the retina, resulting in poor vision. Proactive treatment with intravitreal aflibercept has produced good outcomes in clinical studies. The treat-and-extend dosing strategy in particular has been shown to produce similar visual outcomes to fixed dosing every 4 or 8 weeks. And real-world evidence suggests that patients treated proactively in real life show outcomes similar to those observed in clinical trials. In the ALTAIR study, investigators explored how to fine-tune the proactive treat-and-extend approach in Japanese patients. The study aimed to identify the optimal extension interval for individual patients and individualize treatment with optimal extension to reduce the treatment burden for as many patients as possible. Ideally, treatments would be as infrequent as once every 16 weeks—with fast extensions made in 4-week increments—while maintaining initial vision gains..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Retinal degeneration diseases affect over 200 million people worldwide These diseases cause severe vision loss and can ultimately lead to irreversible blindness While excessive light exposure is known to damage photoreceptors and exacerbate retinal degeneration, the underlying mechanism is unclear, making it difficult to effectively treat these diseases In a recent study, researchers sought to understand the mechanisms driving light-induced photoreceptor cell death Using mouse models, they evaluated the molecular changes that occurred in retinal cells after excessive light exposure The results showed that light activated the molecules mTOR and PARP-1, initiating a unique programmed cell death mechanism termed “parthanatos” Blocking this process protected light-damaged photoreceptors, preventing cell death While additional studies are needed to determine the precise mechanisms involved and how these results translate to humans, the results suggest that targeting mTOR and PARP-1 could lead to strateg.."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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