Summary
Table of Contents

A first person story is presented to the students to hook their interest in the disease. Using a jigsaw approach, students will learn about the fundamentals of Pompe disease and share information during a whole class discussion. The Pompe Predicament was developed as a part of Biomedical Explorations: Bench to Bedside which was supported by the National Center for Research Resources and the Division of Program Coordination, Planning, and Strategic Initiatives of the National Institutes of Health through Grant Number R25RR023294. Additional support provided by the University of Florida (UF) and the UF Center for Precollegiate Education and Training. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.

Learning Goals

1. Describe an enzyme.
2. Explain the role of an enzyme in the human body.
3. Define gene and understand how a gene relates to a protein
4. Explain where a lysosome is located and its role in the function of a cell
5. Explain the genetics of Pompe disease
6. Associate disease pathology with symptoms

title "The Pompe Predicament - Lesson One" 2024 by Julie Bokor
under license"Creative Commons Attribution Non-Commercial Share Alike"

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Cite this work

Lesson One: Looking Through a Father's Eyes

The Pompe Predicament - Lesson One

Created Feb. 7, 2024 by Julie Bokor

A first person story is presented to the students to hook their interest in the disease. Using a jigsaw approach, students will learn about the fundamentals of Pompe disease and share information during a whole class discussion. This activity sets the stage for further investigation of Pompe disease specifically, but more generally the steps of translational research. This lesson also challenges students to think in reverse. We often know the symptoms and pathology of diseases and perform a differential diagnosis to determine which disease fits the symptoms, then proceeding with treatment accordingly. In this lesson, students will understand the basis of the disease, know what cellular structures are affected, deduce the symptoms and propose treatment.

Download: PompeCurriculum_Lesson1.pdf

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Subject:: Life Science
Level:: High School
Material Type:: Activity/Lab, Lesson Plan, Primary Source, Simulation, Teaching/Learning Strategy, Unit of Study

Standards

WY.SCI.HS.LS1.1

Wyoming Science Content and Performance Standards

Grades 9-12

Learning Domain: From Molecules to Organisms: Structure and Processes

Degree of Alignment: Not Rated (0 users)

WY.SCI.HS.LS1.2

Wyoming Science Content and Performance Standards

Grades 9-12

Learning Domain: From Molecules to Organisms: Structure and Processes

Standard: Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multi-cellular organisms.

Degree of Alignment: Not Rated (0 users)

WY.SCI.HS.LS3.1

Wyoming Science Content and Performance Standards

Grades 9-12

Learning Domain: Heredity: Inheritance and Variation of Traits

Standard: Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring.

Degree of Alignment: Not Rated (0 users)

WY.SCI.HS.LS3.2

Wyoming Science Content and Performance Standards

Grades 9-12

Learning Domain: Heredity: Inheritance and Variation of Traits

Degree of Alignment: Not Rated (0 users)

WY.SCI.HS.LS3.3

Wyoming Science Content and Performance Standards

Grades 9-12

Learning Domain: Heredity: Inheritance and Variation of Traits

Standard: Apply concepts of statistics and probability to explain the variation and distribution of expressed traits in a population.

Degree of Alignment: Not Rated (0 users)

NGSS.HS.LS1.1

Next Generation Science Standards

Grades 9-12

Science Domain: Life Sciences

Topic: Structure and Function

Standard: Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells. [Assessment Boundary: Assessment does not include identification of specific cell or tissue types, whole body systems, specific protein structures and functions, or the biochemistry of protein synthesis.]

Degree of Alignment: Not Rated (0 users)

NGSS.HS.LS1.2

Next Generation Science Standards

Grades 9-12

Science Domain: Life Sciences

Topic: Structure and Function

Standard: Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms. [Clarification Statement: Emphasis is on functions at the organism system level such as nutrient uptake, water delivery, and organism movement in response to neural stimuli. An example of an interacting system could be an artery depending on the proper function of elastic tissue and smooth muscle to regulate and deliver the proper amount of blood within the circulatory system.] [Assessment Boundary: Assessment does not include interactions and functions at the molecular or chemical reaction level.]

Degree of Alignment: Not Rated (0 users)

NGSS.HS.LS3.1

Next Generation Science Standards

Grades 9-12

Science Domain: Life Sciences

Topic: Inheritance and Variation of Traits

Standard: Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring. [Assessment Boundary: Assessment does not include the phases of meiosis or the biochemical mechanism of specific steps in the process.]

Degree of Alignment: Not Rated (0 users)

NGSS.HS.LS3.2

Next Generation Science Standards

Grades 9-12

Science Domain: Life Sciences

Topic: Inheritance and Variation of Traits

Standard: Make and defend a claim based on evidence that inheritable genetic variations may result from: (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors. [Clarification Statement: Emphasis is on using data to support arguments for the way variation occurs.] [Assessment Boundary: Assessment does not include the phases of meiosis or the biochemical mechanism of specific steps in the process.]

Degree of Alignment: Not Rated (0 users)

NGSS.HS.LS3.3

Next Generation Science Standards

Grades 9-12

Science Domain: Life Sciences

Topic: Inheritance and Variation of Traits

Standard: Apply concepts of statistics and probability to explain the variation and distribution of expressed traits in a population. [Clarification Statement: Emphasis is on the use of mathematics to describe the probability of traits as it relates to genetic and environmental factors in the expression of traits.] [Assessment Boundary: Assessment does not include Hardy-Weinberg calculations.]

Degree of Alignment: Not Rated (0 users)