This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Farmed chickens often suffer from intestinal inflammation which negatively affects their feed intake, digestion, and growth performance. The gut microbial community has a known close relationship with growth performance, but how, or if, this microbiota influences intestinal inflammation is not yet known. To test this, researchers examined the microbiota in young chickens, focusing on the jejunum section of the gut. They found that 7-week-old chickens with high body weight tended to have a microbiota dominated by gram-positive bacteria, like Lactobacilli. But lower-body-weight chickens had a microbiota dominated by gram-negative bacteria, like Escherichia-Shigella. Gram-negative bacteria carry endotoxin (lipopolysaccharide), and consequently, these lower body weight chickens had more of it in their bloodstream. These elevated lipopolysaccharide levels activated inflammatory cytokines in the jejunum, causing damage to the gut barrier..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotic-resistant bacteria like carbapenem-resistant Enterobacteriaceae (CRE) pose a serious threat to human health. Some resistant pathogens can exist alongside our commensal microbiota at undetectable levels. Antibiotic use can lead to outgrowth of these subclinically colonized bacteria. A recent study sought to better understand the interaction between the gut microbiota and CRE during subclinical colonization and outgrowth. First, researchers exposed wild-type mice to the CRE _K. pneumoniae_. While the levels of _K. pneumoniae_ were not detectable after exposure, the post-exposure microbiome was disrupted. Then, administration of an antibiotic cocktail, ampicillin, vancomycin, or azithromycin induced _K. pneumoniae_ outgrowth while reducing overall microbial diversity. Vancomycin only induced outgrowth in a subset of mice. The researchers found these outgrowth-susceptible mice had differences in mRNA stability pathways and xylose abundance..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The gut microbiome is altered in patients with inflammatory bowel disease and plays an important role in colitis development in mouse models. However, the roles of host-microbe interactions in intestinal inflammation remain unclear and are difficult to study because of interindividual microbiome variability. To address these issues, researchers recently used a reductionist model and multiomics to study host-microbe interactions in wild-type and colitis-prone Was-/- mice. Was-/- mice colonized with both altered Schaedler flora (ASF) and Helicobacter developed colitis, while those colonized with either type alone did not. Bacteria also infiltrated the colon mucus layer in Was-/- mice, and Helicobacter and mucosal Mucispirillum schaedleri were positively correlated with fecal levels of the intestinal inflammation marker LCN2. Consistent with this, fitness- and immunogenicity-enhancing M. schaedleri genes were upregulated in Was-/- mice..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.