This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Cancer-related mortality, a leading cause of death in the US, is driven by tumor invasion and metastasis. Implicated in these processes is epithelial-to-mesenchymal transition, or EMT. EMT drives invasion through a dramatic reorganization of a cell's cytoskeleton and the extracellular matrix. Because EMT is a rare event, undergone by a few abnormal cells, it is difficult to view directly in a patient. But new research methods are providing a lens into this critical process. Culturing cells on planar surfaces is revealing how their EMT behavior is coordinated and driven by leader cells. Research on the protein vimentin highlights its role in enabling cells to contort during migration or proliferation. Other studies examine how topographically patterning culture surfaces changes the behaviors of cells as they slip into and out of EMT. And 3D matrices are being used to examine the dissemination and disorganization of multicellular clusters..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 03/11/2021