This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Inflammation in the brain is a hallmark of many neurodegenerative diseases, including Alzheimer’s and Huntington’s disease. One of the key orchestrators of neuroinflammation is IL-6, a cytokine secreted by brain-resident cells called astrocytes. While low levels of IL-6 support neurons and synapses in the brain higher levels of IL-6 are produced in response to injury or infection, triggering a series of proinflammatory signaling cascades. Unfortunately, how astrocytes regulate IL-6 expression remains unclear. A recent study evaluated signaling pathways involved in IL-6 gene regulation, including β-catenin, TCFs/LEF, C/EBP, and NF-κB. Using human astrocytes, researchers silenced or overexpressed the signaling proteins and measured IL-6 levels. They found that TCF/LEF induces IL-6 in the presence of ATF2, while β-catenin inhibits IL-6 by interacting with TCF/LEF. Interestingly, neither of these signaling pathways is known to regulate IL-6 in other cell types..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 10/30/2020