This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"There may be a silver lining for those at high risk for Alzheimer’s: as the chance of getting the disease goes up, certain treatments may become more effective. The risk of developing Alzheimer’s largely relies on a gene called APOE, with different variants conferring more or less risk. Usually, having a high-risk allele is bad news, but a group of researchers from New York University has reported that carrying the high-risk allele could actually boost responsiveness to immunotherapy, a promising new treatment option. The APOE gene helps determine how much beta-amyloid accumulates in the brain. Beta-amyloid starts as small misfolded bits of protein that clump together to form the plaques that are the hallmark of Alzheimer’s. As the plaques appear, the brain deteriorates, particularly in regions associated with memory. One way to potentially halt this process is to use antibodies that recognize beta-amyloid. The antibodies bind to the protein and signal to the immune system to clear it out..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Genetics
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 11/20/2020