This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antimicrobials are commonly used in agriculture and are important for animal health. This use drives most of the antimicrobial use globally and has led to an increase in antimicrobial resistance (AMR), including resistance to antimicrobials that are critical in human medicine. Researchers recently examined the AMR profiles of over 400 pigs, including wild boars, Tibetan pigs, and commercial pigs, under multiple rearing modes. They identified over a thousand potential antimicrobial resistance gene (ARG) sequences that belonged to 69 different drug resistance classes. From this dataset a few patterns emerged. Tetracycline resistance was the most enriched, but aminoglycoside resistance had the most unique ARGs. Farm-reared pigs had higher AMR levels than semi-free-range pigs or wild boars..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotics are commonly used as both therapeutics and growth promoters in the poultry industry. Antibiotic use in animal husbandry has been linked to proliferation of antimicrobial resistance, but current evidence is indirect. To examine this problem directly, researchers studied the impact of the growth promoter bacitracin and the therapeutic antibiotic enrofloxacin on microbiomes and resistomes. They sampled both cloacal swabs and litter as proxies of gut and environmentally-disseminated microbiomes, coupling standard isolation and metagenomic methodologies. Antibiotic-resistant bacteria and resistance genes were ubiquitous in both the gut and litter and most of the variation in the microbiomes and resistomes was attributable to either growth stage or sample source. But, bacitracin-fed birds had higher levels of bacitracin resistance genes, and a greater proportion of their Enterococcaceae population was vancomycin-resistant..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The gut microbiota plays a critical role in various human cancers. But how can these microbes affect cancers that develop relatively far from the gut? In the case of prostate cancer, new research points to the use of antibiotics. Antibiotics are known to cause gut dysbiosis, which is associated with multiple disorders. In mice with prostate cancer, researchers found that gut dysbiosis caused by antibiotics was linked to tumor growth. Mice given broad-spectrum antibiotics (Abx) showed increased tumor growth compared to control mice (NC). Antibiotics exposure also increased Proteobacteria abundance in mouse guts, a sign of dysbiosis. The mechanism behind these findings could be a leaky gut. Under dysbiosis, a leaky gut barrier allowed the release of lipopolysaccharide (LPS) – an inflammation-inducing factor – into the circulation, which then reached the prostate tumor..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antibiotic use can increase the abundance of antibiotic resistance genes (ARGs) within microbial communities. This occurs in many settings, including in agricultural fields and within the digestive tract of livestock. These two settings interact when manure is used as fertilizer, carrying ARGs from the livestock gut to soil. Earthworms — and their gut microbiomes — play key roles in soil nutrient cycling and are often used as bioindicators in environmental risk assessment. However, the impact of common agricultural antimicrobials or the addition of manure on ARGs in the gut microbiome of earthworms is rarely examined. A recent study found that exposure to the fungicide carbendazim altered their gut microbial community and increased the abundance of ARGs. Specifically, earthworms dwelling in the manure-amended soil had more abundant ARGs in their gut microbiome and exposure to carbendazim enhanced this effect..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Heavy use of antimicrobials can drive the accumulation of antimicrobial resistance genes in a microbiome, including the gut microbiomes of food-producing animals. Pigs are often given antimicrobials when dealing with porcine reproductive and respiratory syndrome (PRRS). While PRRS is caused by a virus, the secondary bacterial infections it leads to are managed with antimicrobials. A recent study investigated the impact of antimicrobials and PRRS infections on the resistome and microbiome of growing commercial pigs. The fecal resistome and microbiome of the young pigs showed a regular development trajectory, influenced primarily by weaning and aging. This trajectory was mostly unchanged by other factors like viral illness, antimicrobial exposure, or the physical grouping of pigs..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.