This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Metabolic syndrome is becoming increasingly common among humans and domestic animals and is thought to be linked to dysfunction in adipose tissue components, including adipose progenitor stem cells (ASCs). The proteins PTP1B and LMPTP have been implicated in the development of metabolic disorders, but their roles in adipogenic differentiation of ASCs and modulation of mitochondrial dynamics in these cells remain unclear. To clarify this issue, a recent study treated ASCs from metabolically impaired horses with PTP1B and LMPTP inhibitors in vitro. Both selective inhibitors enhanced the differentiation of ASCs into adipose cells and increased the expression of PPARγ, a master adipogenesis regulator, while the LMPTP inhibitor increased the expression of adiponectin, which helps protect against metabolic disorders. The compounds also improved antioxidant defense and altered mitochondrial bioenergetics..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 03/01/2022