This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Familial adenomatous polyposis (FAP) is an inherited disorder characterized by the formation of up to several thousand tumors in the rectum and colon. FAP is usually caused by a mutation of the adenomatous polyposis coli (APC) gene. While the molecular changes linking this mutation to tumor formation are not fully understood, dysregulated apoptosis—a form of programmed cell death—is known to play a prominent role. Now, researchers have uncovered a pattern of expression of an apoptosis-regulating protein that may help explain how FAP tumors form. The protein is called apoptosis repressor with caspase recruitment domain, or ARC. The team examined the expression of ARC in 212 FAP tumor samples from 80 patients. They found that ARC was expressed in the cytoplasm of most tumor cells, as well as in the nuclei..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"The composition of our gut microbial community has been linked directly to our health, but researchers are only beginning to study the impact of its functional metabolic behavior, which can shift in response to external factors. Microbial production of H₂S in the gut is one such function, and it may be a colorectal cancer trigger. A recent study used publicly available datasets to examine the sulfur metabolism genes in our gut microbiota. Sulfur metabolism genes were more abundant and diverse than previously thought and were correlated with colorectal cancer. The researchers also examined two key sulfate reductases: dissimilatory sulfite reductases (Dsr) and anaerobic sulfite reductase (asr) and found that genes for asr were twice as abundant as genes for Dsr, suggesting that asr is a more important contributor to sulfate reduction in the human gut and found that genes for asr were twice as abundant as genes for Dsr, suggesting that asr is a more important contributor to sulfate reduction in the human gut..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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