This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, causing diseases including chronic myelogenous and acute lymphoblastic leukemia. Drugs targeting Abl kinase activity serve as paradigms of targeted therapy. Drosophila is an ideal model for studying Abl’s function because there is only a single fly Abl family member. In flies, Abl is essential for embryonic morphogenesis, playing diverse roles in embryonic and adult viability. To examine the role of the intrinsically disordered region (IDR) of Abl, researchers deleted the IDR in Drosophila. They found that Abl lacking the IDR was not able to rescue the roles of Abl in viability and embryonic morphogenesis. The IDR was also essential for cell shape changes and cytoskeletal regulation during embryonic morphogenesis and, surprisingly, for modulating protein stability..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 10/16/2021