Keywords: Excitable Cells (5)

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Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels
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Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels

Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, ... (more)

Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, we describe their molecular architecture, physiological roles, and involvement in genetically determined channelopathies highlighting their relevance as targets for pharmacological treatment of several human disorders. The aim of the present review will be to summarize the current knowledge about the overall architecture, tissue distribution, biophysical properties, regulation and pathophysiological roles of Kv7 channels, thereby setting the basis for their increasingly important pharmacological role. (less)

Subject:
Life Science
Education
Material Type:
Reference
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BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
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BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Francesco Miceli (IRCCS Bambino Ges퀌_ Children's Hospital Division of Neurology)
Maria V. Soldovieri (University of Molise Department of Health Science)
Mauizio Taglialatela (University of Naples Federico II Department of Neuroscience)
Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels- Figure 1
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Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels- Figure 1

This figure illustrates the tissue distribution of Kv7 subunits

Subject:
Life Science
Education
Material Type:
Images and Illustrations
Instructional Material
Lecture Notes
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Francesco Miceli (IRCCS Bambino Ges퀌_ Children's Hospital Division of Neurology)
Maria V. Soldovieri (University of Molise Department of Health Science)
Mauizio Taglialatela (University of Naples Federico II Department of Neuroscience)
Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels- Figure 2
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Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels- Figure 2

This figure shows a schematic representation of a single Kv7.2 subunit

Subject:
Life Science
Education
Material Type:
Images and Illustrations
Instructional Material
Lecture Notes
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Francesco Miceli (IRCCS Bambino Ges퀌_ Children's Hospital Division of Neurology)
Maria V. Soldovieri (University of Molise Department of Health Science)
Mauizio Taglialatela (University of Naples Federico II Department of Neuroscience)
Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels- Figure 3
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Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels- Figure 3

This figure illustrates a summary of voltage-gated K+ currents possibly underlined by ... (more)

This figure illustrates a summary of voltage-gated K+ currents possibly underlined by Kv7 subunits (less)

Subject:
Life Science
Education
Material Type:
Images and Illustrations
Instructional Material
Lecture Notes
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Francesco Miceli (IRCCS Bambino Ges퀌_ Children's Hospital Division of Neurology)
Maria V. Soldovieri (University of Molise Department of Health Science)
Mauizio Taglialatela (University of Naples Federico II Department of Neuroscience)
Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels- Table 1
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Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels- Table 1

This table shows the Kv7 family genes and proteins

Subject:
Life Science
Education
Material Type:
Data
Images and Illustrations
Instructional Material
Lecture Notes
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Francesco Miceli (IRCCS Bambino Ges퀌_ Children's Hospital Division of Neurology)
Maria V. Soldovieri (University of Molise Department of Health Science)
Mauizio Taglialatela (University of Naples Federico II Department of Neuroscience)
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2002 llaF ,gnivloS melborP gnireenignE dna sretupmoC ot noitcudortnI

.desu si egaugnal gnimmargorp avaJ ehT .gninnalp dna ,tnemeganam ,ecneics ,gnireenigne ni ... (more)

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