This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Researchers at the RIKEN Center for Sustainable Resource Science have developed a new genetic pathway that can be used to co-opt E. coli bacteria to produce maleate, one of the most important industrial chemicals in use today. A chief component in the coatings of substances like nylon and galvanized steel and an important stabilizing agent in pharmaceuticals, maleate is typically produced through harsh treatments of crude oil. But by using genetically engineered microorganisms to produce maleate, the researchers have developed a much more sustainable approach. Maleate is the end product of a complex chemical reaction. Bacteria don’t normally come equipped with machinery to power this reaction, so the researchers had to design a ground-up approach before they could start harvesting maleate. This required careful analysis of the intermediates needed for maleate synthesis and the identification of genes that could help E. coli make each of these molecules..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Students are presented with an engineering challenge that asks them to develop a material and model that can be used to test the properties of aortic valves without using real specimens. Developing material that is similar to human heart valves makes testing easier for biomedical engineers because they can test new devices or ideas on the model valve instead of real heart valves, which can be difficult to obtain for research. To meet the challenge, students are presented with a variety of background information, are asked to research the topic to learn more specific information pertaining to the challenge, and design and build a (prototype) product. After students test their products and make modifications as needed, they convey background and product information in the form of portfolios and presentations to the potential buyer.

The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs.

This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.

Students operate mock 3D bioprinters in order to print tissue constructs of bone, muscle and skin for a fictitious trauma patient, Bill. The model bioprinters are made from ordinary materials— cardboard, dowels, wood, spools, duct tape, zip ties and glue (constructed by the teacher or the students)—and use squeeze bags of icing to lay down tissue layers. Student groups apply what they learned about biological tissue composition and tissue engineering in the associated lesson to design and fabricate model replacement tissues. They tangibly learn about the technical aspects and challenges of 3D bioprinting technology, as well as great detail about the complex cellular composition of tissues. At activity end, teams present their prototype designs to the class.

Students further their understanding of the engineering design process while combining mechanical engineering and bioengineering to create an automated medical device. During the activity, students are given a fictional client statement and are required to follow the steps of the design process to create medical devices that help reduce the workload for hospital workers and increase the quality of patient care.

Bioengineering at MIT is represented by the diverse curricula offered by most Departments in the School of Engineering. This course samples the wide variety of bioengineering options for students who plan to major in one of the undergraduate Engineering degree programs. The beginning lectures describe the science basis for bioengineering with particular emphasis on molecular cell biology and systems biology. Bioengineering faculty will then describe the bioengineering options in a particular engineering course as well as the type of research conducted by faculty in the department.

Students learn about the current applications and limitations of 3D bioprinting, as well as its amazing future potential. This lesson, and its fun associated activity, provides a unique way to review and explore concepts such as differing cell functions, multicellular organism complexity, and engineering design steps. As introduced through a PowerPoint® presentation, students learn about three different types of bioprinters, with a focus on the extrusion model. Then they learn the basics of tissue engineering and the steps to design printed tissues. This background information prepares students to conduct the associated activity in which they use mock-3D bioprinters composed of a desktop setup that uses bags of icing to “bioprint” replacement skin, bone and muscle for a fictitious trauma patient, Bill. A pre/post-quiz is also provided.

This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, rigorous data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on genome engineering, expression engineering, and biomaterial engineering.
This OCW site is based on the source OpenWetWare class Wiki, found at 20.109(F07): Laboratory Fundamentals of Biological Engineering.

This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on RNA engineering, protein engineering, and cell-biomaterial engineering.
This OCW site is based on the source OpenWetWare class Wiki, 20.109(S10): Laboratory Fundamentals of Biological Engineering.

Students learn the function of the liver and how biomedical engineers can use liver regeneration to help people. Students test the effects of toxic chemicals on a beef liver by adding hydrogen peroxide to various liver and salt solutions. They observe, record and graph their results.

Student teams build model hand dynamometers used to measure grip strengths of people recovering from sports injuries. They use their models to measure how much force their classmates muscles are capable of producing, and analyze the data to determine factors that influence a person's grip strength. They use this information to produce a recommendation of a hand dynamometer design for a medical office specializing in physical therapy. They also consider the many other ways grip strength data is used by engineers to design everyday products.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Biodiesel from plant oils could be the fuel of the future, but the low quality of certain plant oils means that getting there will take some engineering. So, researchers are turning to genetics for a solution. They’ve developed a transgenic soybean line that could dramatically increase biodiesel performance. Biodiesel performance relies on the fatty acid composition of the source oil. On average, soybean oil is only 25% oleic acid, which is a desirable monounsaturated fatty acid, and 13% palmitic acid, an undesirable saturated fatty acid. This fatty acid profile negatively affects biodiesel’s rate of nitrogen oxide emission and freezing point. Through metabolic engineering, the soybean genes FAD2-1 and FatB were down-regulated using RNA interference technology to increase the production of oleic acid to nearly 95% and decrease the production of palmitic acid to less than 3%, with no detectable differences in the fatty acid chemical structure between modified and standard soybean lines..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Students learn about the separation techniques of sedimentation and centrifugation and investigate whether blood is a homogeneous or a heterogeneous mixture. Working in groups as if they are biomedical researchers, they employ the scientific method and make observations about the known characteristics of urine, milk and blood. They probe further by analyzing research on the properties and fractionation modes of blood. As students learn about certain strange characteristics with the fractionation behavior of blood, they formulate hypotheses on the unique nature of blood. Using provided materials —olive oil, tomato juice and petroleum jelly—they design an experiment and construct a blood model. They test their hypotheses by conducting experiments on the blood model, and then propose theories for the nature of blood as a mixture—arriving at the theory of mixture dualism in blood—that blood is a complex mixture system. An activity-guiding handout and PowerPoint® presentation are provided for this student-directed, project-based activity.

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to give guest lectures.

Students are introduced to various types of hearing impairments and the types of biomedical devices that engineers have designed to aid people with this physical disability.

Students further their understanding of the engineering design process (EDP) while being introduced to assistive technology devices and biomedical engineering. They are given a fictional client statement and are tasked to follow the steps of the EDP to design and build small-scale, off-road wheelchair prototypes. As part of the EDP, students identify appropriate materials and demonstrate two methods of representing solutions to their design problem (scale drawings and simple scale models). They test the scale model off-road wheelchairs using spring scales to pull the prototypes across three different simulated off-road surfaces.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"NOTCH1 is a protein implicated in various diseases, including breast cancer. In order to control Notch signaling, researchers have developed a light-activated tool called OptoNotch. OptoNotch is an engineered form of NOTCH1 that is activated under blue light. This mimics NOTCH1’s natural activation program: activation, release from the plasma membrane, translocation to the nucleus, and initiation of potentially harmful expression of different genes. The ability to activate NOTCH1 using only light makes OptoNotch highly targeted and easier to implement than chemical- or genetic-based systems. When deployed in two lines of breast cancer cells, OptoNotch could track how NOTCH1 contributed to accelerated cell proliferation, as well as cell migration, the phenotype of cancer cells in 3D cultures, mimicking patients' tumors, and resistance to common chemotherapy drugs. OptoNotch could help scientists to understand the roles of NOTCH1 in normal and disease conditions, and help screen for promising drug candidates..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

To gain a better understanding of the roles and functions of components of the human respiratory system and our need for clean air, students construct model lungs that include a diaphragm and chest cavity. They see how air moving in and out of the lungs coincides with diaphragm movement. Then student teams design and build a prototype face mask pollution filter. They use their model lungs to evaluate their prototypes to design requirements.

Students follow the steps of the engineering design process while learning more about assistive devices and biomedical engineering applied to basic structural engineering concepts. Their engineering challenge is to design, build and test small-scale portable wheelchair ramp prototypes for fictional clients. They identify suitable materials and demonstrate two methods of representing design solutions (scale drawings and simple models or classroom prototypes). Students test the ramp prototypes using a weighted bucket; successful prototypes meet all the student-generated design requirements, including support of a predetermined weight.