Cellular Neurophysiology, Spring 2002

Abstract:: Surveys the molecular and cellular mechanisms of neuronal communication. Covers ion channels in excitable membrane, synaptic transmission, and synaptic plasticity. Correlates the properties of ion channels and synaptic transmission with their physiological function such as learning and memory. Discusses the organizational principles for the formation of functional neural networks at synaptic and cellular levels.

"From Molecules to Behavior: Synaptic Neurophysiology, Spring 2010"

Abstract:: "Like transistors in a computer, synapses perform complex computations and connect the brain's non-linear processing elements (neurons) into a functional circuit. Understanding the role of synapses in neuronal computation is essential to understanding how the brain works. In this course students will be introduced to cutting-edge research in the field of synaptic neurophysiology. The course will cover such topics as synapse formation, synaptic function, synaptic plasticity, the roles of synapses in higher cognitive processes and how synaptic dysfunction can lead to disease. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching."

Abstract:: In this course we will discover how innovative technologies combined with profound hypotheses have given rise to our current understanding of neuroscience. We will study both new and classical primary research papers with a focus on the plasticity between synapses in a brain structure called the hippocampus, which is believed to underlie the ability to create and retrieve certain classes of memories. We will discuss the basic electrical properties of neurons and how they fire. We will see how firing properties can change with experience, and we will study the biochemical basis of these changes. We will learn how molecular biology can be used to specifically change the biochemical properties of brain circuits, and we will see how these circuits form a representation of space giving rise to complex behaviors in living animals. A special emphasis will be given to understanding why specific experiments were done and how to design experiments that will answer the questions you have about the brain. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.