This case study uses a PowerPoint (~1MB) combined with role-playing to present the epidemiology and pathophysiology of Severe Acute Respiratory Syndrome (SARS). Students learn about the etiology and pathophysiology of the disease, and then argue different health professionals' perspectives on a plan of action for dealing with its consequences. Developed for a pathophysiology course for undergraduates, the case could also be used in a microbiology course or in a course in public or international health.

This case study is based on another case in our collection, The 2000-Meter Row: A Case in Homeostasis, which emphasizes the metabolic, respiratory, and cardiac responses of a young athlete competing in a championship rowing event. In this modified version, the same event is viewed in a new light to explore the psychological ramifications of the stressful sports competition. The case was developed for a mixed undergraduate-graduate course in sport psychology.

The physically demanding sport of competitive rowing is the backdrop for this case about homeostasis in which students follow the physiological changes that occur in an athlete competing in a 2000-meter race. The case was developed for use in a second-year anatomy and physiology course. It would also be appropriate in exercise and sports science classes.

As the carbon dioxide concentration of our atmosphere increases and our climate warms, the hay fever season seems to be getting longer and more severe. In this case study, students assume the a role of a public relations specialist contracted to communicate the link between climate change and pollen allergies. The activity focuses on the importance of scientific skills to careers outside science, and is most suitable for a lower-level introductory biology, human health, or environmental science course.

Renowned virologist and member of the prestigious National Academy of Science, Peter Duesberg has argued that AIDS is not caused by HIV, but is the result of recreational and anti-HIV drugs. In this PBL case, students read Duesberg's 1999 article in Science magazine titled "HIV is Not the Cause of AIDS" as well as a response to it titled "HIV Causes AIDS" by medical researchers Dr. William A. Blattner and colleagues. Students work in groups to identify the issues as well as any terms or concepts they don't understand, then research these out of class to pool their information as they learn about AIDS and HIV.

This case introduces students to HIV, its life cycle, treatment, and problems associated with treatment options. The case, which incorporates critical thinking skills, active learning, self-directed study, and peer-to-peer learning, was developed for use in an undergraduate upper-level biology course entitled "The Molecular Basis of Disease." It could also be used in an immunology class, a molecular evolution class, or a general biology class to introduce viruses.

This case was developed for use in the first semester of a sophomore organic chemistry laboratory to illustrate how a combination of techniques is usually required in the identification of chemical compounds. It involves a murder mystery with a forensic twist. Students are told that two bodies have recently been recovered from two different lakes. Due to a mix-up at the morgue, the coroner's office is unable to determine which body came from which lake. The students' task is to develop a methodology to solve this mystery as well as determine whether the deaths were the result of murder or mishap. The case could also be used in instrumental analysis courses or adapted for a non-majors course in the general education curriculum.

In this "clicker case," a three-year-old girl gets into the medicine cabinet and ingests an unknown number of aspirin tablets. Her brother calls 911 and the girl is taken to a nearby hospital, where she is treated. The case is used to discuss the Law of Mass Action, chemical equilibrium and equilibrium constants, pH, and weak acids and buffers in the context of medical management of a life-threatening emergency. It is called a "clicker" case because it is designed to be presented in a class that uses personal response systems, or "clickers." The case is presented via a series of PowerPoint slides (~400KB) punctuated by multiple-choice questions, which the students answer using their clickers. It could be adapted for use without these technologies. The case is suitable for use in an introductory biology course where integration with biologically relevant chemistry is an important course objective. It could also be used in a chemistry course.

Playfully alluding to Lewis Carroll's tale of Alice Through the Looking Glass, this case study considers the problems that would arise if a person were to cross over into a mirror-image environment. Students read about a drowsy undergraduate studying for a stereochemistry exam who finds herself in a place where spearmint gum tastes like caraway seed. The case emphasizes the lock-and-key theory of enzyme action and stresses the need for molecules to have the proper chirality if they are to be biologically useful. Designed for introductory organic chemistry and biochemistry courses, the case could also be used in biology courses.

This "clicker case" follows Susan, an intern at a local hospital, who has admitted a patient she discovers has used the drug Ecstasy. The girl becomes delirious, and Susan begins to suspect that she may be suffering from water intoxication. The case is designed for an introductory biology course for either science or non-science majors, though it could be adapted for upper level courses. It uses an example of water intoxication to introduce membrane structure and function, osmosis, and electrolyte balance in the body. The case itself is a PowerPoint presentation (~800KB) shown in class that is punctuated by multiple-choice questions students answer using clickers. It could be adapted for use without these technologies.

Aircraft are complex products comprised of many subsystems which must meet demanding customer and operational lifecycle value requirements. This course adopts a holistic view of the aircraft as a system, covering: basic systems engineering; cost and weight estimation; basic aircraft performance; safety and reliability; lifecycle topics; aircraft subsystems; risk analysis and management; and system realization. Small student teams "retrospectively analyze" an existing aircraft covering: key design drivers and decisions; aircraft attributes and subsystems; and operational experience. Finally, the student teams deliver oral and written versions of the case study.

Subject addresses a holistic systems engineering approach for aircraft development. Focuses on the conceptual phase of product definition during which all aspects relevant to a new or derivative aircraft must be considered. These include technical, economic, market, environmental, regulatory, legal, manufacturing, and societal factors. Subject centers on a realistic aircraft system case study and includes a number of lectures from industry and government. Past examples included the Very Large Transport Aircraft and a Supersonic Business Jet. Subject identifies the critical system level issues and analyzes them in depth via student team projects and individual assignments. The overall goal of the semester is to produce a business plan and aircraft level system specifications document which can serve as an independent assessment of a current candidate aircraft system. Aircraft are complex products comprised of many subsystems which must meet demanding customer and operational lifecycle value requirements. This course adopts a holistic view of the aircraft as a system, covering: basic systems engineering; cost and weight estimation; basic aircraft performance; safety and reliability; lifecycle topics; aircraft subsystems; risk analysis and management; and system realization. Small student teams "retrospectively analyze" an existing aircraft covering: key design drivers and decisions; aircraft attributes and subsystems; and operational experience. Finally, the student teams deliver oral and written versions of the case study.

16.885J offers an holistic view of the aircraft as a system, covering: basic systems engineering; cost and weight estimation; basic aircraft performance; safety and reliability; lifecycle topics; aircraft subsystems; risk analysis and management; and system realization. Small student teams retrospectively analyze an existing aircraft covering: key design drivers and decisions; aircraft attributes and subsystems; and operational experience. Oral and written versions of the case study are delivered. For the Fall 2005 term, the class focuses on a systems engineering analysis of the Space Shuttle. It offers study of both design and operations of the shuttle, with frequent lectures by outside experts. Students choose specific shuttle systems for detailed analysis and develop new subsystem designs using state of the art technology.

In this decision case, a congressional staffer must weigh a number of competing concerns and issues, including popular reactions to genetically modified organisms, in deciding how to present information to her boss, an influential congressman drafting legislation to support agricultural research. The case explores the social and biological issues surrounding micronutrient malnutrition, including deficiencies of several vitamins and essential minerals, especially iron, iodine, and vitamin A, which affect at least one-third of the world's population, primarily in developing nations. Developed for a graduate-level seminar on "Genomics, Agriculture, Food Systems and Development," the case teaches about the issues surrounding genomic applications in agriculture and their implications to health, environmental stewardship, economic sustainability, and national development.

When chronic pain forces a top student to withdraw from college, biology instructor Dr. Sharpe learns that medications (in this case, Vioxx) may be removed from the market for many reasons, including safety concerns. As the case unfolds, students learn how the FDA balances drug safety against medical needs. As written, the case is appropriate for a non-majors biology course. It could also be adapted for use in a more advanced course in cell biology, pharmacology, or biochemistry, or modified to explore statistical analysis, specific analytical methods used for risk/benefit analysis, or bioethical issues.

This problem-based case focuses on the female menstrual cycle and early stages of pregnancy of an unwed teenager. Working in small groups, students identify the learning issues for each part of the story and research answers to their questions. They are then given more of the case to evaluate. The cycle of analysis, information seeking, and sharing is repeated for each stage of the case. The case can be used in numerous settings including general health, biology, and sociology classes or in more specialized courses such as physiology, endocrinology, nursing, medicine, human development, social services, or counseling.

Intelligent Design continues to be a hot political and educational topic in some parts of the country. This discussion case study uses the dramatic setting of a public school board as it considers whether district science teachers should be made to read a statement to their classes identifying Intelligent Design as a competing theory to evolution that is worthy of scientific consideration. The relevant statement is in fact the one that was at the center of the 2004 controversy in Dover, Pennsylvania. This case would be appropriate in general biology or advanced courses where the focus is on evolution.

In chronicling the life and death of a woman who developed diabetes as a teenager, this case study explores such basic science topics as metabolism, hormones, cell receptors, eye anatomy, and immunology as well as issues in nutrition, exercise, stem cell research, transplantation, drug delivery systems, genetic engineering, and health care. The case has been used in a physiology course as part of a unit on metabolism and hormonal control.

This case study presents a fictitious bio-terrorist plan to release anthrax in the United States. Students are assigned character roles and, through research, role-playing, and teamwork, develop a plan to minimize or avert the attack. The case is appropriate for courses designed for health professionals, general biology courses, and social science courses.