Howard Hughes Medical Institute

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Howard Hughes Medical Institute Collection Resources (198)

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AIDS: Evolution of an Epidemic, Lecture 3: Drugs and HIV Evolution
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This video from the Howard Hughes Medical Institute is from the 2007 Holiday Lectures on Science: "AIDS: Evolution of an Epidemic." Bisola O. Ojikutu, M.D., M.P.H. discusses antiretroviral therapy in AIDS and HIV. The video is available as an indexed video with synchronized slides or webcast video only. Both require RealPlayer. The video is 58 minutes and 31 seconds long and there are 91 slides.

Subject:
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Author:
Bisola O. Ojikutu, M.D., M.P.H.
Amoeboid Sperm of C. Elegans
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Video closeup of the C. elegans sperm that moves like an amoeba. This video is featured on the HHMI DVD, The Meaning of Sex: Genes and Gender, available free from HHMI. Also, this video is 10 seconds in length, and available in Quicktime (0.8 MB) and Windows Media (1 MB). All sex determination videos are located at: http://www.hhmi.org/biointeractive/gender/video.html.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Antigen presentation and CTL
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How a cell infected by a virus signals cytotoxic T lymphocytes to kill the cell before the virus replicates and spreads. This video is two minutes and 34 seconds in length, and available in Quick Time (11 MB) and Windows Media Player (23 MB). All Infection Disease Animations are located at: http://www.hhmi.org/biointeractive/disease/animations.html.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Antlers and Mammalian Regeneration
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Dr. Rosenthal describes how antlers are one of the few examples of complete mammalian regeneration. This video presentation is also featured on the DVD Potent Biology: Stem Cells, Cloning, and Regeneration, available free from HHMI. This video is two minutes and 18 seconds in length, and available in Quicktime (24 MB) and Windows Media (35 MB) formats. All Stem Cells videos are located at: http://www.hhmi.org/biointeractive/stemcells/video.html.

Subject:
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Author:
Dr. Rosenthal
Bacterial Growth
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Dr. Brett Finlay shows how bacteria can grow rapidly to incredible numbers, and also explains what limits this explosive growth. This resource would be great preparation material for a classroom discussion or video presentation for both the students and the teacher. This visual helps further broaden the knowledge of students in both the upper high school and college undergraduate on bacterial growth. The lecture is featured on the DVD 2000 and Beyond: Confronting the Microbe Menace, available free from HHMI. The video is 54 seconds long and available on WMV (10MB) and MOV (8MB). All Infection Disease videos can be found at http://www.hhmi.org/biointeractive/disease/video.html .

Subject:
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Biodiversity and Evolutionary Trees
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Explore principles of taxonomy by sorting seashells according to their morphological characteristics and constructing an evolutionary tree.

Subject:
Biology
Material Type:
Activity/Lab
Lecture
Lesson Plan
Provider:
Howard Hughes Medical Institute
Provider Set:
Exploring Biodiversity: The Search for New Medicines
Author:
HHMI
Breeding Corn from Teosinte
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Corn was originally bred from the teosinte plant by native Mexican farmers. The morphologies of modern-day corn and teosinte plants are compared to illustrate how artificial selection can bring about dramatic changes in plants. This video is also featured on the DVD Evolution: Constant Change and Common Threads, available free from HHMI. This video is 52 seconds in length, and available in MOV (13 MB) and WMV (16 MB). All Evolution videos are located at: http://www.hhmi.org/biointeractive/evolution/video.html.

Subject:
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
C. Elegans Mating
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Video microscopy of mating between a male and a hermaphrodite C. elegans roundworm. This video featured on the HHMI DVD, The Meaning of Sex: Genes and Gender, available free from HHMI. Also, this video is 56 seconds in length, and available in Quicktime (2 MB) and Windows Media (3 MB). All sex determination videos are located at: http://www.hhmi.org/biointeractive/gender/video.html.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
CTL Killing a Target Cell
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This one minute and sixteen second video from Howard Hughes Medical Institute depicts the microscopy of a cytotoxic T lymphocyte in action. This video is available in QuickTime (MOV) and Windows Media format (WMV). It is also featured on the 2007 Holiday Lectures: AIDS: Evolution of an Epidemic. More information on this and other infectious disease videos can be found at http://www.hhmi.org/biointeractive/disease/video.html .

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Cheek Cells and Bacteria
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Rating

Dr. Brett Finlay enlists a student volunteer to show the surprisingly high amount of bacteria found in his own mouth. This resource is also featured on the DVD 2000 and Beyond: Confronting the Microbe Menace, available free from HHMI. This video is one minute and 27 seconds in length, and available in MOV (8 MB) and WMV (12 MB). All Infectious Disease videos are located at: http://www.hhmi.org/biointeractive/disease/video.html.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Author:
Dr. Brett Finlay
Clonal vs Sexual Reproduction
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Rating

What does a stack of fruits and vegetables have to do with the theoretical advantages of sexual reproduction? Find out in this demonstration with student audience members and Dr. David Page. This video featured on the HHMI DVD, The Meaning of Sex: Genes and Gender, available free from HHMI. Also, this video is 8 minutes and 55 seconds in length, and available in Quicktime (63 MB) and Windows Media (94 MB). All sex determination videos are located at: http://www.hhmi.org/biointeractive/gender/video.html.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Cloning an Army of T Cells for Immune Defense
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Rating

View the animation to see how one type of immune cell-the helper T cell-interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of the helper T cell. These identical T cells can serve as a brigade forming an essential communication network to activate B cells, which make antibodies that will specifically attack the activating antigen.

Subject:
Health, Medicine and Nursing
Chemistry
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Color Variation over Time in Rock Pocket Mouse Populations
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This activity provides an introduction to natural selection and the role of genetic variation by asking students to analyze illustrations of rock pocket mouse populations (dark/light fur) on different color substrates in the Sonoran Desert (light/dark) over time. Based on this evidence, and what they learn about variation and natural selection in the accompanying short film, students use this evidence to explain the change in the rock pocket mouse populations on the lava flow (dark substrate) over time. This is one of several classroom activities, focusing on related topics and varying in complexity, built around the short film. This ten minute film shows adaptive changes in rock pocket mouse populations, demonstrating the process of natural selection and can be accessed at http://www.hhmi.org/biointeractive/making-fittest-natural-selection-and-adaptation. The film is also available as an interactive video with embedded questions, which test students’ understanding as they watch the film.

Subject:
Genetics
Material Type:
Lesson Plan
Provider:
Howard Hughes Medical Institute
National Science Teachers Association (NSTA)
Provider Set:
NGSS@NSTA
Author:
Mary Colvard
Creating Embryonic Stem Cell Lines
Conditions of Use:
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Rating

The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Diagram/Illustration
Lecture
Reading
Simulation
Provider:
Howard Hughes Medical Institute
Cultured Human Embryonic Stem Cells
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Cell cultures derived from human embryonic stem cells can reproduce indefinitely and also differentiate into specialized cell types, including beating heart cells. This presentation is also featured on the DVD Potent Biology: Stem Cells, Cloning, and Regeneration, available free from HHMI. This video is one minute and 17 seconds in length, and available for download in Quicktime (8 MB) and Windows Media (11 MB) formats. All Stem Cell videos are located at: http://www.hhmi.org/biointeractive/stemcells/video.html.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
DNA Gene Chip Explanation
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Rating

Dr. Melton describes the process used to extract DNA from a cell and to analyze it on a gene chip. This video presentation is also featured on the DVD Potent Biology: Stem Cells, Cloning, and Regeneration, available free from HHMI. This video is 57 seconds in length, and available in Quicktime (13 MB) and Windows Media (20 MB) formats. All Stem Cell videos are located at: http://www.hhmi.org/biointeractive/stemcells/video.html.

Subject:
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Author:
Dr. Melton
DOS Matrix
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Rating

In diversity-oriented synthesis, many combinations of chemical building blocks undergo relatively few reaction steps to form a vast variety of different molecules. In this example, 45 x 45 x 45 combinations yield more than 88,000 novel molecules.

Subject:
Health, Medicine and Nursing
Chemistry
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
The Day the Mesozoic Died
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Rating

This three-act film tells the story of the detective work that solved the mystery of what caused the disappearance of the dinosaurs at the end of the Cretaceous period. Shot on location in Italy, Spain, Texas, Colorado, and North Dakota, the film traces the uncovering of key clues that led to the discovery that an asteroid struck the Earth 66 million years ago, triggering a mass extinction of animals, plants, and microorganisms. Science practices in geology, physics, biology, chemistry and paleontology all contributed to the solution to this compelling mystery. Lesson plans are included that have students identify evidence and construct an explanation to tie it together. Summary questions are included at the end and a class discussion is recommended. (This activity will be the only one evaluated in this review.) Another resource is “Finding the Crater” where students “visit” different K-T boundary sites. There are also lessons where students analyze various characteristics of the asteroid such as its size and energy, chemical data about the asteroid, and the iridium fallout from an asteroid impact. A hands-on activity where students study the differences in foraminifera fossils below and above the K-T boundary is also included as well as an article that outlines more details about each of the discoveries covered in the film. You can view the film on the website or HHMI will send you a free DVD. Lesson plans including teacher notes and a student handout can be found at http://www.hhmi.org/biointeractive/following-trail-evidence.

Subject:
Biology
Material Type:
Lesson Plan
Provider:
Howard Hughes Medical Institute
National Science Teachers Association (NSTA)
Provider Set:
NGSS@NSTA
Author:
Mary Colvard
Demo: Rapid AIDS virus test
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This seven minute, forty second video from Howard Hughes Medical Institute shows a live demonstration of how a rapid antibody-based HIV test works. This video is available in QuickTime (MOV) and Windows Media (WMV) formats, and is featured on the 2007 Holiday Lecture DVD, AIDS: Evolution of an Epidemic. This and other video is available for free at: http://www.hhmi.org/biointeractive/disease/video.html.

Subject:
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Diversity-Oriented Synthesis
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Rating

Diversity-oriented synthesis (DOS) is a strategy used by chemical biologists to create a huge diversity of small molecules with potentially useful properties. A scientist working in Dr. Stuart Schreiber's lab shows us how engineering, computer science, chemistry, and biology are all used in DOS. This video is featured on the DVD Scanning Life's Matrix: Genes, Proteins, and Small Molecules, available free from HHMI. Also this video is 5 minutes and 41 seconds in length, and available in Quicktime (37 MB) and Windows Media (44 MB). All Genomics videos are located at: http://www.hhmi.org/biointeractive/genomics/video.html.

Subject:
Computer Science
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Diversity of Small Molecules
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A molecular menagerie of small molecules is displayed, with two particular molecules singled out for attention: rapamycin and Furrowstatinss, which are discussed in the remainder of Dr. Schreiber's lectures on chemical genetics.

Subject:
Health, Medicine and Nursing
Biology
Chemistry
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Dog Breeding
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Rating

The many forms of dogs that exist today were all created through selective breeding from the dog's ancestor, the wolf. In a span of less than 10,000 years, breeders have changed traits and body shapes of dogs by artificial selection-for example, emphasizing different aspects of hunting and herding behavior. This selection is also featured on the DVD Evolution: Constant Change and Common Threads, available free from HHMI. This video is one minute and 52 seconds in length, and available in MOV (14 MB) and WMV (20 MB). All Evolution videos are located at: http://www.hhmi.org/biointeractive/evolution/video.html.

Subject:
Zoology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Dosage Compensation in C. Elegans
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Rating

A demonstration by Dr. Barbara Meyer of how a branched genetic pathway can be affected by mutations in different parts of the pathway. This video featured on the HHMI DVD, The Meaning of Sex: Genes and Gender, available free from HHMI. Also, this video is 8 minutes and 55 seconds in length, and available in Quicktime (22 MB) and Windows Media (38 MB). All sex determination videos are located at: http://www.hhmi.org/biointeractive/gender/video.html.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Echocardiogram
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Dr. Christine Seidman describes a live demonstration of an echocardiogram, with a description of the parts of the heart that are visualized. Also featured on the DVD Hearts and Hypertension: Blazing Genetic Trails, available free from HHMI. Also, this video is 4 minutes and 44 seconds in length, and available in QuickTime (27 MB) and Windows Media Player (30 MB). All cardiovascular videos are located at: http://www.hhmi.org/biointeractive/cardiovascular/video.html.

Subject:
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute
Embryonic Cell Division in C. Elegans
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Rating

Time-lapse microscopy showing cell division from 1 to 2 to 4 cell stages in C. elegans with fluorescent chromosomes. This video is featured on the HHMI DVD, The Meaning of Sex: Genes and Gender, available free from HHMI. Also, this video is 1 minute and 30 seconds in length, and available in Quicktime(3 MB) and Windows Media (4 MB). All sex determination videos are located at: http://www.hhmi.org/biointeractive/gender/video.html.

Subject:
Health, Medicine and Nursing
Biology
Material Type:
Lecture
Provider:
Howard Hughes Medical Institute