Subject:
Applied Science, Life Science, Biology
Material Type:
Module
Level:
Community College / Lower Division, College / Upper Division
Provider:
Rice University
Tags:
Adaptive Immune Response, Adaptive Immune System, Adaptive Immunity, Allergies, Allergy, Antibodies, Antibody, Antibody Class, Antibody Function, Antibody Structure, Antigen, Antigen-presenting Cell, Apc, Autoantibody, Autoimmune Response, Autoimmunity, Avidity, B-cell, Basophil, CTL, Cell-mediated Immune Response, Clonal Selection, Complement System, Cross-reactivity, Cytokine, Cytokine Release, Cytotoxic T Lymphocyte, Dendritic Cell, ELISA, Effector Cell, Enzyme-linked Immunosorbent Assay, Eosinophil, Epitope, Granzyme, Helper T Cell, Helper T Lymphocyte, Humoral Immune Response, Hypersensitivities, Hypersensitivity, Immune Response, Immune System, Immune Tolerance, Immunity, Immunodeficiency, Inflammation, Innate Immune Response, Innate Immune System, Innate Immunity, Interferon, Lymph, MHC, MHC I, MHC II, Macrophage, Major Histocompatability Class I Molecule, Major Histocompatability Class II Molecule, Malt, Mast Cell, Memory Cell, Monocyte, Mucosa-associated Lymphoid Tissue, NK, Natural Killer Cell, Neutrophil, Opsonization, PAMP, PRR, Passive Immunity, Pathogen, Pathogen Recognition, Pathogen-associated Molecular Pattern, Pattern Recognition Receptor, Perforin, Plasma Cell, Regulatory T Cell, T Cell
License:
Creative Commons Attribution-NonCommercial 4.0
Language:
English
Introduction

Introduction

Section 1

Micrograph shows a blood smear. The neutrophil and eosinophil are similar in structure, but the eosinophil is larger. Both are filled with granular structures, and have three purple-stained nuclei. These white blood cells are surrounded with donut-shaped red blood cells.
In this compound light micrograph purple-stained neutrophil (upper left) and eosinophil (lower right) are white blood cells that float among red blood cells in this blood smear. Neutrophils provide an early, rapid, and nonspecific defense against invading pathogens. Eosinophils play a variety of roles in the immune response. Red blood cells are about 7–8 µm in diameter, and a neutrophil is about 10–12µm. (credit: modification of work by Dr. David Csaba)

The environment consists of numerous pathogens, which are agents, usually microorganisms, that cause diseases in their hosts. A host is the organism that is invaded and often harmed by a pathogen. Pathogens include bacteria, protists, fungi and other infectious organisms. We are constantly exposed to pathogens in food and water, on surfaces, and in the air. Mammalian immune systems evolved for protection from such pathogens; they are composed of an extremely diverse array of specialized cells and soluble molecules that coordinate a rapid and flexible defense system capable of providing protection from a majority of these disease agents.

Components of the immune system constantly search the body for signs of pathogens. When pathogens are found, immune factors are mobilized to the site of an infection. The immune factors identify the nature of the pathogen, strengthen the corresponding cells and molecules to combat it efficiently, and then halt the immune response after the infection is cleared to avoid unnecessary host cell damage. The immune system can remember pathogens to which it has been exposed to create a more efficient response upon re-exposure. This memory can last several decades. Features of the immune system, such as pathogen identification, specific response, amplification, retreat, and remembrance are essential for survival against pathogens. The immune response can be classified as either innate or active. The innate immune response is always present and attempts to defend against all pathogens rather than focusing on specific ones. Conversely, the adaptive immune response stores information about past infections and mounts pathogen-specific defenses.