Interacting with law enforcement can be a very negative experience. This lesson provides vocabulary and body language exercises that may help students have more positive interactions with police. The ‘ponder’ activities are designed to give students tools to change how they are perceived.
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"RNA base-editing tools enable scientists to study gene function and develop treatments for genetic diseases. The pioneering tool REPAIR changes A bases into I bases, while the newer RESCUE system changes A and C bases into I and U bases, respectively. However, both systems tend to edit unintended, or off-target, sites in addition to desired sites. To enable more precise RNA editing, researchers recently designed a new system, ecRESCUE, by fusing the destabilization domain (DD) of the E. coli protein ecDHFR to the RESCUE system. The DD degrades the two RESCUE proteins (dRanCas13b and ADAR2) unless the drug TMP is present, making the system drug-inducible. In vitro, ecRESCUE was just as effective as RESCUE in the presence of TMP, but ecRESCUE-mediated editing was greatly reduced in the absence of TMP. When 3 specific sites were targeted, TMP-induced ecRESCUE made many fewer off-target edits than RESCUE..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.