This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"In the absence of oxygen, some prokaryotes can degrade organic matter via anaerobic digestion. This occurs in natural settings, like wetlands, and industrial ones, like wastewater treatment or biogas production. But what about viruses? Bacteriophages can impact their hosts’ community structure through selective pressure and have been used to influence microbial communities, such as through pathogen control. A recent study examined the virome of anaerobic digestion communities undergoing prophage- inducing environmental stresses. The virome was almost entirely composed of tailed bacteriophages of the order Caudovirales. Metagenome reconstruction revealed 1,092 viral genomes and 120 prokaryotic genomes, and over half of the prokaryotic genomes contained a provirus in their genomic sequence. In general, species of viruses and prokaryotes could be grouped by having similar reactions to stressors. Archaea had the most pronounced reactions to stressors and featured behaviors unique to those species..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This example Socratic questioning page provides an outline for leading a classroom discussion regarding whether or not viruses are alive. Sample questions, resources for background information, and tips and assessment information are provided.

The aim of this presentation is to expand the student knowledge about skin microbiology. The main skin microbes are bacteria, viruses and fungi, which normally are friendly without causing harms. However, the skin flora is constantly challenges by our every-day life activities.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The birth of a child involves many big transitions, but one of these changes occurs inside the child, who transitions from the sterile womb to an outside environment full of microbes. While this has lasting effects on growth, inflammation, and immunity, remarkably little is known about how gut bacteria and viruses are acquired by infants. Recently, researchers used next-generation sequencing to evaluate microbes from the guts of 28 pairs of twins and their mothers. They found that the majority of the infant’s gut bacteria were similar to their mother’s gut bacteria. Viruses were less similar, suggesting they might be transmitted through other routes. Twins also shared more of their gut microbiota with each other, emphasizing the strong effect of environmental exposure, and mode of delivery had very little effect on how much of the infants’ gut microbiome was inherited from their mothers..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The Center for Food Safety and Applied Nutrition (CFSAN) prepared this online handbook on foodborne pathogenic microorganisms (bacteria, viruses and parasites) and natural toxins. Chapters are arranged under the following headings: Pathogenic Bacteria, Enterovirulent Escherichia Coli Group, Parasitic Protozoa and Worms, Viruses, Natural Toxins, Other Pathogenic Agents, and Appendices. The intent of each chapter is to provide basic facts regarding these organisms and toxins including their characteristics, habitat or source, associated foods, infective dose, characteristic disease symptoms, complications, recent and/or major outbreaks, and any susceptible populations. The chapters also contain minimal information on the analytical methods used to detect, isolate, and/or identify the pathogens or natural toxins.

This material is labwork meant to be used in conjunction with the Candela "Biology II" course.

This 23-minute video provides an introduction to viruses. [Biology playlist: Lesson 19 of 71].

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Birds can carry and transmit viruses to humans and other animals. Thus, understanding the viral community hosted by birds could help us predict future outbreaks of human disease. A recent metagenomics study took a broad look at the viruses found in the gut of wild and captive birds. The dataset included samples from over 3,000 birds that represented over 87 species and 10 different phylogenetic orders and the researchers characterized genomes from numerous viral families including astroviruses, coronaviruses, parvoviruses, and adenoviruses. Examining trends, they found that wild birds had higher viral diversity than captive birds. There was also evidence of potential cross-species transmission between wild birds and domestic poultry. Further analysis of the viral genomic sequences revealed differences in virus distribution patterns between wild and captive birds. Different phylogenetic orders of birds and geographic sites also had distinct distribution patterns..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Microbial interactions play a crucial role in the functioning and biogeochemical cycling of Earth's ecosystem. But these connections are highly dynamic and poorly understood. A clear picture of how microbes interact over time could help gain insight into processes that influence nutrient cycling, productivity, and the overall health of marine ecosystems. Researchers investigated microbial dynamics in the Mediterranean Sea on a monthly basis over 10 years. To pinpoint persistent, seasonal, and temporary microbial associations, the researchers identified a temporal network capturing the interactomes of each sample. This network followed an annual cycle that collapsed and reassembled with changes in water temperature. And microbial associations were more repeatable in colder versus warmer months. However, only 16 associations could be validated in the literature, underlining a serious knowledge gap in marine microbial ecological interactions..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new study published in Genome Medicine adds to the growing body of evidence that Parkinson’s disease is linked to microbes in the gut. Investigating the composition and function of this microbial community, the research team found pronounced differences between healthy patients and those in the early stages of the disease. Parkinson’s disease is most commonly associated with tremors, muscle stiffness, and impaired movement. While these symptoms are caused by the breakdown of nerve cells in the brain, the root cause and progression of this disorder are still not fully understood. Emerging evidence, however, suggests microorganisms found in the intestines may have something to do with it. The human gut contains trillions of microbes, including bacteria, archaea, fungi, and viruses. These organisms, collectively termed the microbiome, have been suggested to profoundly impact human health and disease..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In our increasingly globalized world, a single infected person can board a plane and spread a virus across continents. Mark Honigsbaum describes the history of pandemics and how that knowledge can help halt future outbreaks. A quiz, thought provoking question, and links for further study are provided to create a lesson around the 8-minute video. Educators may use the platform to easily "Flip" or create their own lesson for use with their students of any age or level.

Try your hand at this immunology crossword puzzle that uses vocabulary from CELLS alive! If you have trouble, use the "Search this Site" engine in the lefthand menu. Good Luck!

Because viruses invade host cells to take over a host's cellular machinery, the innate system has a more difficult time detecting viruses as foreign agents. However, there is a give-away element of the viral attack that the innate system can recognize: the double-stranded RNA (dsRNA) produced by a virus in its replication phase. Because mammalian cells only ever produce single-stranded RNA, the presence of dsRNA signals a foreign intruder. dsRNA can be detected by TLR-3R on the cell surface or intracellularly by the presence of dsRNA-dependent protein kinase.

7.016 Introductory Biology provides an introduction to fundamental principles of biochemistry, molecular biology, and genetics for understanding the functions of living systems. Taught for the first time in Fall 2013, this course covers examples of the use of chemical biology and twenty-first-century molecular genetics in understanding human health and therapeutic intervention.
The MIT Biology Department Introductory Biology courses 7.012, 7.013, 7.014, 7.015, and 7.016 all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.

In this activity on page 1 of the PDF, learners compare the relative sizes of biological objects (like DNA and bacteria) that can't be seen by the naked eye. Learners will be surprised to discover the range of sizes in the microscopic world. This activity can be followed up with a second activity, "What's in a microbe?", located on page 3 in the same resource.

This is an interactive learning adventure for middle school students and has accompanying classroom activities and magazines. In Mission Three: Nemesis in Neuropolis, students learn about viruses and vaccines while investigating a smallpox case.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Deep shale formations underlie most of North America and are typically inhospitable to microbial life. However, hydrologic fracturing of shale creates space and injects moisture and nutrients into the system, thus allowing new microbial communities to form. These communities can cause problems by corroding infrastructure and souring the hydrocarbon steam. Understanding the behavior of these microbial communities could lead to better management techniques. Recently, researchers examined the microbial genomes and metabolic capacity of fractured shale wells in Oklahoma, USA. Oklahoma shale is much hotter and has lower salinity than the previously characterized formations in the eastern USA. This study found that the Oklahoma formations had greater microbial taxonomic and metabolic diversity than the eastern formations. Sampling over time revealed that this microbial community broke down complex polymers from the fracturing process and used them for nutrients..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Cancer is a leading cause of mortality worldwide. Some types of cancer are linked to infection by viruses and bacteria, but many such links remain unexplored, indicating that other carcinogenic microbes are likely to exist. A recent study used a large, high-quality collection of 3025 whole-genome sequencing datasets to identify relationships between cancer, bacteria, and viruses. A custom-built pipeline based on the Kraken taxonomic sequence classification system software was used to identify bacterial and viral sequences in the datasets. A total of 3,534,707 read pairs matching 218 bacterial, viral, or phage species-level taxa were detected in tumor and matched healthy tissues. Of these, 27 taxa were identified to be linked to cancer. The findings support known associations between viruses, bacteria, and tumor and patient phenotypes and also reveal entirely new associations. For example, Pseudomonas spp..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Welcome to the Teachers' Corner of Small Things Considered. In this section, we include the posts we deem most adequate for teaching purposes. We have reorganized them into subject areas geared for a typical microbiology course. To date, this material has been used for various forms of intellectual enrichment, e.g., suggested readings, class presentations, a source of topics for term papers. You can also find here our Talmudic Questions, which we characterize as those whose answers cannot be found in Google. We are told that some of these questions have been used in exams ranging from tests for undergraduate courses to qualifying/prelims for graduate students.

6.857 Network and Computer Security is an upper-level undergraduate, first-year graduate course on network and computer security. It fits within the Computer Systems and Architecture Engineering concentration.