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  • RNA Interference
Cell Biology: Structure and Functions of the Nucleus, Spring 2010
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The goal of this course is to teach both the fundamentals of ...

The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression.

Subject:
Biology
Material Type:
Full Course
Textbooks
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Sharp, Phillip
Young, Richard
Experimental Molecular Biology: Biotechnology II, Spring 2005
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Laboratory uses yeast as an experimental system to study fundamental problems in ...

Laboratory uses yeast as an experimental system to study fundamental problems in understanding cell cycle and chromosome segregation. Experimental work combines genetic approaches with the tools of molecular and cell biology to identify and characterize novel genes that act on these processes. Instruction and practice in written and oral communication provided.

Subject:
Biology
Material Type:
Full Course
Textbooks
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Non-coding RNAs: Junk or Critical Regulators in Health and Disease?, Spring 2012
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Every time we scientists think that we have dissected the precise biological ...

Every time we scientists think that we have dissected the precise biological nature of a process, an incidental finding, a brilliantly designed experiment, or an unexpected result can turn our world upside down. Until recently thought by many to be cellular "junk" because they do not encode proteins, non-coding RNAs are gaining a growing recognition for their roles in the regulation of a wide scope of processes, ranging from embryogenesis and development to cancer and degenerative disorders. The aim of this class is to introduce the diversity of the RNA world, inhabited by microRNAs, lincRNAs, piRNAs, and many others. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

Subject:
Literature
Biology
Material Type:
Full Course
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Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Nadya Dimitrova
Thales Papagiannakopoulos
RNA Interference: A New Tool for Genetic Analysis and Therapeutics, Fall 2004
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Seminar covering topics of current interest in biology. Includes reading and analysis ...

Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. To understand and treat any disease with a genetic basis or predisposition, scientists and clinicians need effective ways of manipulating the levels of genes and gene products. Conventional methods for the genetic modification of many experimental organisms are technically demanding and time consuming. Just over 5 years ago, a new mechanism of gene-silencing, termed RNA interference (RNAi), was discovered. In addition to being a fascinating biological process, RNAi provides a revolutionary technology that has already changed the way biomedical research is done and that may even prove useful for genetic interventions in a clinical context. In this course, students learn how RNAi was discovered, how it works, and what its physiological relevance might be. How RNAi can be harnessed to modulate gene expression and perform genetic screens, both in cells and in various organisms is also covered. Finally, this course examines the first attempts to use RNAi for the treatment of models of human diseases in experimental animals.

Subject:
Biology
Material Type:
Full Course
Textbooks
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Kissler, Stephan
Ventura, Andrea