Biology is designed for multi-semester biology courses for science majors. It is …
Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.
By the end of this section, you will be able to:Describe the …
By the end of this section, you will be able to:Describe the different steps in RNA processingUnderstand the significance of exons, introns, and splicingExplain how tRNAs and rRNAs are processed
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"RNA base editing has great potential for use in research for cell functions and genetic disease. Unlike DNA editing, which can cause unwanted mutations in other parts of the genome, RNA editing may allow researchers to mimic genetic variants that provide a health advantage. Two main RNA base editors have been used in vitro: REPAIR, which mediates A-to-I editing, and RESCUE, which can perform both C-to-U and A-to-I editing. Unfortunately, although RESCUE is more versatile, its low editing efficiency limits its applications. Now, researchers have developed an enhanced RESCUE (eRESCUE) system. eRESCUE was generated by fusing inactivated PspCas13b with ADAR2. In tests using human cell lines, eRESCUE mediated more efficient A-to -I and C-to-U RNA editing than the original RESCUE editor. eRESCUE editing of IKKβ successfully converted 177Ser to Gly, resulting in decreased phosphorylation and downregulation of downstream IKKβ-related genes..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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