This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"When patients undergo general anesthesia, there’s a shift in the distribution of ventilation and perfusion throughout the lung, with more areas of the lung getting too much air, relative to the amount of blood flow, and others getting too little. This type of scatter is traditionally described by Riley’s three-compartment model, in which high-ratio lung regions getting less blood flow produce increases in the alveolar deadspace. But new work published in the journal Anesthesiology shows that this model fails to account for different blood solubilities of various anesthetics -- and shows how multicompartment models better predict what is happening in the lungs. The researchers extended an earlier study in anesthetized patients that found that partial pressure measurements of inhaled anesthetic in the lungs did not match those made for carbon dioxide -- and were inconsistent with the three-compartment theory..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In this capstone course, students will use new and previous knowledge about drug delivery and biopharmaceutics, to design an innovation. Throughout the course students will engage in learning opportunities related to real-world scenarios in drug delivery, gain a better understanding of the anatomy and physiology related to drug delivery, and participate in a self-directed project to solve a fictitious problem. This learning tool will guide students through the process of understanding real-world applications of drug delivery and how drug delivery is applied to treating infectious diseases. DDF’s innovation project is aligned with NGSS and Common Core standards in math and ELA core curriculum subject areas. The learning activities, final project, and mid-unit assessments are provided to the teacher and students in the form of eLearning readings, quizzes, interactive tools, student response sheets, and presentation outlines. Students using this module should find success in self-directed learning, though they may use additional resources in the community, the guidance of teachers, the advice of scientists or biomedical professionals at DDF, or the knowledge presented in scientific literature to help them achieve their goal; though this module should provide most of the tools they will need for guidance. For more information on in-person learning experiences, please contact our DDF eLearning Project Manager, Lindsay Malcolm: lmalcolm@tsrlinc.com

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and has high rates of recurrence and death. In patients with advanced HCC and poor liver function, surgery and ablation aren’t very effective, so pharmacotherapy is typically used. However, traditional antitumor drugs don’t have ideal properties or efficacy, and they’re highly toxic to normal cells. Recently developed nanotechnologies have shown promise for improving drug kinetics and efficacy against HCC. For example, nanoparticles can deliver drugs to tumor tissues and affect specific cells and molecules in the tumor microenvironment. These nanocarriers can reach their targets passively (due to intrinsic tumor characteristics) or actively (via molecules engineered onto their surfaces). Drug release from the nanoparticles can be induced by conditions common in tumors, such as hypoxia and acidification or by externally applied stimuli, such as light, heat, ultrasound, and magnetic fields..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A recent report in the journal Cancer Science adds to the growing body of evidence demonstrating that prexasertib is a promising option for several types of cancer. Two prior clinical trials conducted in the United States showed prexasertib has both antitumor activity and an acceptable safety profile. A new clinical trial extends these findings by looking at how the drug performs in a new demographic of patients – namely, Japanese patients with advanced solid tumors. Prexasertib is a novel inhibitor of the protein checkpoint kinase 1 – a serine/threonine kinase that promotes DNA repair, controls initiation of DNA replication, and coordinates mitosis. Blocking the protein’s activity prevents cells from resolving replication stress and/or repairing DNA double-strand breaks, which leads to apoptosis. Inhibitors of checkpoint kinase 1 can augment the efficacy of DNA‐damaging chemotherapeutics, but they’re also being evaluated as single-agent therapies..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.