This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"CCL2 is a small cell-signaling protein that recruits immune cells to sites of inflammation. CCR2 is CCL2’s receptor. Together, CCL2 and CCR2 create an inflammatory and immune-suppressive microenvironment, which promotes tumor growth and progression and induces resistance to anticancer drugs. A recent review highlights research on the therapeutic potential of targeting this so-called “CCL2-CCR axis”. Circulating levels of CCL2 are particularly elevated in individuals with obesity. Studies on men with prostate cancer suggest that inhibiting CCL2 signaling can significantly inhibit tumor growth and invasion. More work is needed to differentiate natural CCL2 levels in patients from tumor-derived CCL2 involved in the formation and spread of tumors, which could lead to new ways of attacking cancer and cancer resistance..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 10/30/2020
