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3D-ection: Molecular Shape Recognition
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In this activity, learners explore how molecules self-assemble and how molecules must ... More

In this activity, learners explore how molecules self-assemble and how molecules must fit together, like a lock and key, in order to identify each other and initiate a new function as a combined unit. Learners use play-dough and keys to design their own molecular models that demonstrate how shapes of molecules are important to self-assembly. <br> <br> Note: The write-up for this activity starts on the bottom of page 12. <br> Less

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Subject:
Engineering
Education
Life Science
Chemistry
Physics
Material Type:
Activities and Labs
Data
Instructional Material
Lesson Plans
Provider:
Science and Math Informal Learning Educators (SMILE)
Provider Set:
SMILE Pathway: Science and Math Activities in One Search
Author:
Arizona Science Center
Science Education Partnership Award, National Institutes of Health
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3D-tection: Trying to Fit In
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In this activity, learners explore how molecules must fit together, like a ... More

In this activity, learners explore how molecules must fit together, like a lock and key, in order to identify each other and initiate a new function as a combined unit. By fitting their hands into uniquely-shaped Play-dough models, learners simulate how receptors recognize each other and stick together based on their distinctive three-dimensional forms. This activity includes an optional extension, in which learners match objects to impressions of the objects in play-dough. Use this activity to introduce concepts related to nanotechnology, self-assembly, antigens, and antibodies. Less

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Subject:
Engineering
Life Science
Chemistry
Physics
Material Type:
Activities and Labs
Data
Instructional Material
Lesson Plans
Provider:
Science and Math Informal Learning Educators (SMILE)
Provider Set:
SMILE Pathway: Science and Math Activities in One Search
Author:
Arizona Science Center
Science Education Partnership Award, National Institutes of Health
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AP Statistics Curriculum 2007
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This is an Internet-based E-Book for advanced-placement (AP) statistics educational curriculum. The ... More

This is an Internet-based E-Book for advanced-placement (AP) statistics educational curriculum. The E-Book is initially developed by the UCLA Statistics Online Computational Resource (SOCR), however, all statistics instructors, researchers and educators are encouraged to contribute to this effort and improve the content of these learning materials. Less

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Subject:
Computer Science
Engineering
Education
Life Science
Ecology
Forestry and Agriculture
Mathematics
Physics
Material Type:
Instructional Material
Textbooks
Provider:
NSDL Staff
Shodor
Provider Set:
Mathematics Gateways and Resources
CSERD: Computational Science Education Reference Desk
Author:
Statistics Online Computational Resource
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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
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Background MUC2 mucin produced by intestinal goblet cells is the major component ... More

Background MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterized the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis. Methods and FindingsBy murine N-ethyl-N-nitrosourea mutagenesis we identified two distinct noncomplementing missense mutations in Muc2 causing an ulcerative colitis-like phenotype. 100% of mice of both strains developed mild spontaneous distal intestinal inflammation by 6 wk (histological colitis scores versus wild-type mice, p , 0.01) and chronic diarrhea Monitoring over 300 mice of each strain demonstrated that 25% and 40% of each strain, respectively, developed severe clinical signs of colitis by age 1 y. Mutant mice showed aberrant Muc2 biosynthesis, less stored mucin in goblet cells, a diminished mucus barrier, and increased susceptibility to colitis induced by a luminal toxin. Enhanced local production of IL-1b, TNF-a, and IFN-c was seen in the distal colon, and intestinal permeability increased 2-fold. The number of leukocytes within mesenteric lymph nodes increased 5-fold and leukocytes cultured in vitro produced more Th1 and Th2 cytokines (IFN-c, TNF-a, and IL-13). This pathology was accompanied by accumulation of the Muc2 precursor and ultrastructural and biochemical evidence of endoplasmic reticulum (ER) stress in goblet cells, activation of the unfolded protein response, and altered intestinal expression of genes involved in ER stress, inflammation, apoptosis, and wound repair. Expression of mutated Muc2 oligomerisation domains in vitro demonstrated that aberrant Muc2 oligomerisation underlies the ER stress. In human ulcerative colitis we demonstrate similar accumulation of nonglycosylated MUC2 precursor in goblet cells together with ultrastructural and biochemical evidence of ER stress even in noninflamed intestinal tissue. Although our study demonstrates that mucin misfolding and ER stress initiate colitis in mice, it does not ascertain the genetic or environmental drivers of ER stress in human colitis.Conclusions Characterization of the mouse models we created and comparison with human disease suggest that ER stress-related mucin depletion could be a fundamental component of the pathogenesis of human colitis and that clinical studies combining genetics, ER stress-related pathology and relevant environmental epidemiology are warranted. Less

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Material Type:
Images and Illustrations
Video Lectures
Provider:
SciVee
Provider Set:
SciVee
Author:
mmcguckin
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Abuse-a-Cyst
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In this activity, learners examine how brine shrimp populations can survive in ... More

In this activity, learners examine how brine shrimp populations can survive in some of the harshest environments. Learners subject brine shrimp cysts to extreme conditions to evaluate the hardiness of these creatures. Less

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Subject:
Education
Life Science
Ecology
Forestry and Agriculture
Genetics
Anthropology
Material Type:
Activities and Labs
Instructional Material
Lesson Plans
Provider:
Genetic Science Learning Center
NSDL Staff
Science and Math Informal Learning Educators (SMILE)
Provider Set:
Teach.Genetics
Key Concepts in Biology
SMILE Pathway: Science and Math Activities in One Search
Author:
University of Utah
Utah's WIRED (Workforce Innovation In Regional Economic Development) program
Westminster College
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Accelerating Biology with Bioinformatics: Collaborations with Lab Scientists
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Projects to facilitate collaboration between biologists and computer scientists. Lecture from the ... More

Projects to facilitate collaboration between biologists and computer scientists. Lecture from the Women in Bioinformatics series. Fran Lewitter, Ph.D. Director of the Bioinformatics and Research Computing Department, Whitehead Institute, MIT Less

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Subject:
Computer Science
Biology
Chemistry
Material Type:
Images and Illustrations
Video Lectures
Provider:
SciVee
Provider Set:
SciVee
Author:
WomenInBioinformatics
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.)310.1( tcejbus ngised enotspac eht dna )150.1 ,140.1 ,130.1( stcejbus ngised aera ... More

.)310.1( tcejbus ngised enotspac eht dna )150.1 ,140.1 ,130.1( stcejbus ngised aera ytlaiceps tneuqesbus eht ni desu si hcihw decudortni si esac ngised egral A .naps efil detcepxe dna ,srotcaf laicos dna cimonoce ,tnemnorivne larutan ,tnemnorivne tliub gnitsixe eht fo noitaredisnoc sa llew sa sehcaorppa lacinhcet snrecnoc ylticilpxe ngised tcejorP .)sdaor dna segdirb ,sgnidliub ,.g.e( seitilicaf tliub no sisahpme na htiw ,sesac ngised lareves sedulcnI .gnireenigne livic ni secitcarp dna seussi ngised sa llew sa ,gnivlos-melborp evitaerc dna ngised gnireenigne fo seuqinhcet dna ,sloot ,yroeht eht ot stneduts secudortnI Less

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