This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"New research suggests that a low-calorie diet might help reverse symptoms of type 2 diabetes in men with obesity. The findings of the study add to a growing body of evidence indicating that diabetes is a reversible condition. Authors of the study looked at 18 men in South Africa who were over the age of 35, had class III obesity, and were on insulin treatment for diabetes. The participants were randomized to one of two groups: one followed a commercially available low-fat, low-calorie diet consisting of vegetables and a vegetable-soup-based meal plan; while the control group received a calorie-restricted meal plan. All participants were encouraged to engage in physical activity according to their abilities and to visit a counseling psychologist at least once a month. Over the course of 6 months, the team tracked the men’s levels of blood glucose and glycated hemoglobin, or HbA1c—using those measures to establish diabetes status..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

By the end of this section, you will be able to:Name and describe lung volumes and capacitiesUnderstand how gas pressure influences how gases move into and out of the body

By the end of this section, you will be able to:Describe how oxygen is bound to hemoglobin and transported to body tissuesExplain how carbon dioxide is transported from body tissues to the lungs

This 15-minute video lesson examines hemoglobin and its role in the circulatory system. [Biology playlist: Lesson 40 of 71].

This 16-minute video looks at oxygen uptake by hemoglobin in red blood cells. [Biology playlist: Lesson 38 of 71].

Revised for Human Gas Exchange and simplified somewhat.By the end of this section, you will be able to:Name and describe lung volumes and capacitiesUnderstand how gas pressure influences how gases move into and out of the body

Although mom controls the oxygen source, the fetus has a couple of clever tricks to get the most oxygen possible! Rishi is a pediatric infectious disease physician and works at Khan Academy.

This lesson describes how the circulatory system works, including the heart, blood vessels and blood. Students learn about the chambers and valves of the heart, the difference between veins and arteries, and the different components of blood. This lesson also covers the technology engineers have developed to repair the heart if it is damaged. Students also understand how the circulatory system is affected during spaceflight (e.g., astronauts lose muscle in their heart during space travel).

Students randomly select jelly beans (or other candy) that represent genes for several human traits such as tongue-rolling ability and eye color. Then, working in pairs (preferably of mixed gender), students randomly choose new pairs of jelly beans from those corresponding to their own genotypes. The new pairs are placed on toothpicks to represent the chromosomes of the couple's offspring. Finally, students compare genotypes and phenotypes of parents and offspring for all the "couples" in the class. In particular, they look to see if there are cases where parents and offspring share the exact same genotype and/or phenotype, and consider how the results would differ if they repeated the simulation using more than four traits.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"No pregnant woman wants to hear that her developing baby has a life-threatening genetic disease. Historically, women carrying babies with alpha thalassemia major, a type of hereditary anemia, faced the difficult choice between terminating a pregnancy or continuing on despite nearly assured fetal death. Now, researchers at UCSF have reported another option: in utero blood transfusion, or IUT. In this procedure, healthy red blood cells are infused into the fetus, which can reverse the effects of ATM and increase the chance of survival. Fetal hemoglobin – a protein with two alpha and two gamma subunits – is the main oxygen supplier in utero. Patients with ATM lack alpha subunits. As a result, their hemoglobin holds oxygen so tightly that it cannot be released into developing tissues. While a lack of oxygen is harmful at any age, the effects in utero are particularly severe – depriving a developing brain of oxygen, for example, can cause devastating neurologic injury..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"People with diabetes who require basal insulin to achieve blood glucose control can be at risk of hypoglycaemia, where blood glucose levels drop too low. In randomised clinical trials (or RCTs), use of second-generation basal insulin analogues, such as insulin glargine 300 units/mL (known as glargine 300) and insulin degludec, results in similar glycated haemoglobin reductions compared with first-generation basal insulin analogues, such as glargine 100 and insulin detemir, but with less hypoglycaemia. However, it is not known whether these results translate directly to routine clinical practice, as RCTs often apply strict inclusion and exclusion criteria, meaning that they may not be generalisable to real-life situations. Electronic medical records are a source of rich real-world data, but using them to make comparisons between different treatments can be difficult because results might be biased by confounding data, something that the randomisation in RCTs is designed to minimise..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

The Online Macromolecular Museum (OMM) is a site for the display and study of macromolecules. Macromolecular structures, as discovered by crystallographic or NMR methods, are scientific objects in much the same sense as fossil bones or dried specimens: they can be archived, studied, and displayed in aesthetically pleasing, educational exhibits. Hence, a museum seems an appropriate designation for the collection of displays that we are assembling. The OMM's exhibits are interactive tutorials on individual molecules in which hypertextual explanations of important biochemical features are linked to illustrative renderings of the molecule at hand.

Why devote a site to detailed visualizations of different macromolecules? In learning about the intricacies of life processes at the molecular level, it is important to understand how natural selection has fashioned the structure and chemistry of macromolecular machines to suit them for particular functions. This understanding is greatly facilitated by the visualization of 3-dimensional structure, when known. So, if static views of molecules (even in stereo) are worth a thousand words, then interactive animations of molecules should be worth much more. Indeed, we have found the types of displays represented here invaluable in gaining an appreciation for the details of key biochemical processes.

As Carl Brandon and John Tooze stated in their classic text, Introduction to Protein Structure:
"Molecular biology began some 40 years ago with the realization that structure was crucial for a proper understanding of function. Paradoxically, the dazzling achievements of molecular genetics and biochemistry led to the eclipse of structural studies. We believe the wheel has now come full circle, and those very achievements have increased the need for structural analysis at the same time that they have provided the means for it."

It is our opinion that structural analysis should extend into the classroom: as students learn about cellular mechanisms it is important that they study the chemistry of the molecular machines involved. These considerations have motivated the construction of the OMM.

The OMM is part of a collaborative effort by faculty and students interested in macromolecular structure-function relationships. The primary authors of some tutorials are students of David Marcey and he serves as author, co-author and site editor, and assumes all responsibility for content. Any criticisms, suggestions, comments, or questions should be sent to him at: marcey@callutheran.edu. All tutorials are copyrighted.

The OMM was started in 1996 for a Molecular Biology class at Kenyon College, where DM was a professor in the Biology Department (1990-1999). The OMM is now developed and housed at California Lutheran University, where DM has been a professor since 1999.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A recently completed clinical trial of the oral drug eliglustat has delivered promising long-term results for adults with Gaucher disease type 1 – a rare and sometimes life-threatening genetic disorder that interferes with the breakdown of certain types of lipids. GD1 is caused by deficient activity of the lysosomal enzyme acid β-glucosidase. Reduced catalytic activity of the enzyme results in pathogenic accumulation of the enzyme’s substrates, primarily glucosylceramide, in various organs. The result is progressive and debilitating enlargement of the spleen and liver, anemia, low platelet counts, and skeletal manifestations. The historical standard of care is biweekly intravenous infusions of recombinant enzyme, which boosts degradation of glucosylceramide. By contrast, eliglustat, an oral substrate reduction therapy, reduces glucosylceramide storage by slowing its production..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

In a class discussion format, the teacher presents background information about basic human genetics. The number of chromosomes in both body cells and egg and sperm cells is covered, as well as the concept of dominant and recessive alleles. Students determine whether or not they possess the dominant allele for the tongue-rolling gene as an example.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Physicians may soon be able to get a detailed look at blood vessels surrounding breast tumors quickly, painlessly, and without radiation, thanks to the work of a team of Japanese researchers. One application of the technology is earlier and more accurate tracking of when cancer has turned deadly. The formation of new blood vessels around a tumor is a key sign that cancer is getting ready to spread. But getting a clear look at these blood vessels can be tricky. Approaches like MRI or computed tomography often come with a hefty price tag, and exposure to contrast agent or radiation may pose health risks. To sidestep these issues, the researchers optimized a way to perform photoacoustic imaging. This type of imaging utilizes the light-absorbing properties of hemoglobin to show where blood is flowing in the body. When hemoglobin is exposed to pulses of laser light, it produces small vibrations. These vibrations are picked up by scanners and used to generate a detailed map of blood vessel architecture..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.