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Med Myst: Mission 1, Orientation at O.R.B.
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This is an interactive learning adventure for middle school students and has ...

This is an interactive learning adventure for middle school students and has accompanying classroom activities and magazines. In this challenge, students will perform experiments to identify the germ responsible for a fungal disease. Students will follow rules or postulates worked out by Dr. Koch in the late 1800s for establishing whether a specific germ causes a particular infectious disease: 1. The suspected pathogen must be present in every case of the disease; 2. The suspected pathogen must be isolated from the host and grown in pure culture; 3. The disease must be reproduced when a pure culture of the suspected pathogen is inoculated into a healthy susceptible host; 4. The same pathogen must be recovered from the newly infected host. The Germ Theory of Disease holds that germs or microorganisms cause infectious diseases. Funded through the National Center for Research Resources and the National Institute of Allergy and Infectious Diseases.

Subject:
Biology
Material Type:
Activity/Lab
Game
Interactive
Lesson Plan
Provider:
Rice University
Provider Set:
Rice Center for Technology in Teaching and Learning
Med Myst: Mission 2, Peril in Prokaryon
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This is an interactive learning adventure for middle school students and has ...

This is an interactive learning adventure for middle school students and has accompanying classroom activities and magazines. In Mission Two: Peril in Prokaryon, students learn about infectious pathogens and epidemiology while investigating a cholera outbreak.

Material Type:
Activity/Lab
Case Study
Game
Provider:
Rice University
Provider Set:
Rice Center for Technology in Teaching and Learning
Lesson 2: Maternal Nutrition during Pregnancy and Lactation
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Some diseases are nutritionally related either through excess or deficiency of certain ...

Some diseases are nutritionally related either through excess or deficiency of certain nutrients. This unit will provide you with the basic knowledge that you need to understand how nutrition, infection and disease relate to each other. The unit also describes what can be done in order to break the Nutrition дус infection cycle.

Subject:
Nutrition
Material Type:
Reading
Provider:
WikiEducator
Molecular Biology for the Auditory System, Fall 2002
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An introductory course in the molecular biology of the auditory system. First ...

An introductory course in the molecular biology of the auditory system. First half focuses on human genetics and molecular biology, covering fundamentals of pedigree analysis, linkage analysis, molecular cloning, and gene analysis as well as ethical/legal issues, all in the context of an auditory disorder. Second half emphasizes molecular approaches to function and dysfunction of the cochlea, and is based on readings and discussion of research literature.

Subject:
Biology
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Skvorak Giersch, Anne B.
Genomics and Computational Biology, Fall 2002
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Subject assesses the relationships between sequence, structure, and function in complex biological ...

Subject assesses the relationships between sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive functional-genomics analyses. Topics include: algorithmic, statistical, database, and simulation approaches; and practical applications to biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations critically assessed. Problem sets and project emphasize creative, hands-on analyses using these concepts. From the course home page: In addition to the regular lecture sessions, supplementary sections are scheduled to address issues related to Perl, Mathematica and biology.

Subject:
Biology
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Church, George McDonald
Computing for Biomedical Scientists, Fall 2002
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Introduces abstraction as an important mechanism for problem decomposition and solution formulation ...

Introduces abstraction as an important mechanism for problem decomposition and solution formulation in the biomedical domain, and examines computer representation, storage, retrieval, and manipulation of biomedical data. Examines effect of programming paradigm choice on problem-solving approaches, introduces data structures and algorithms. Presents knowledge representation schemes for capturing biomedical domain complexity. Teaches principles of data modeling for efficient storage and retrieval. The final project involves building a medical information system that encompasses the different concepts taught in the subject.

Subject:
Computer Science
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Boxwala, Aziz A.
Ogunyemi, Omolola
Medical Computing, Spring 2003
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The focus of the course is on medical science and practice in ...

The focus of the course is on medical science and practice in the age of automation and the genome, both present and future. It includes an analysis of the computational needs of clinical medicine, a review systems and approaches that have been used to support those needs, and an examination of new technologies.

Subject:
Computer Science
Health, Medicine and Nursing
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Ohno-Machado, Lucila
Survival Skills for Researchers: The Responsible Conduct of Research, Spring 2003
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Provides graduate students and fellows with techniques that enhance both validity and ...

Provides graduate students and fellows with techniques that enhance both validity and responsible conduct in scientific practice. Topics include study design, laboratory practice, treatment of data, human and animal research, intellectual property, preparation of proposals, research papers, posters, and oral presentations. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated as appropriate to the specific topic under discussion. Subject satisfies the training grant requirements of the NIH for education in the responsible conduct of research. This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of proposals and manuscripts, peer review, authorship, use of humans and non-human animals in research, allegations of misconduct, and intellectual property. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated into lectures and case discussion as appropriate to the specific topic. This course also satisfies the training grant requirements of the NIH for education in the responsible conduct of research.

Subject:
Health, Medicine and Nursing
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Bird, Stephanie J.
Mallalieu, Sandra
Principle and Practice of Human Pathology, Spring 2003
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Subject provides a comprehensive overview of human pathology with emphasis on mechanisms ...

Subject provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and modern diagnostic technologies. Topics include: general mechanisms of disease (inflammation, infection, immune injury, host response to foreign materials, transplantation, genetic disorders and neoplasia); pathology of lipids, enzymes, and molecular transporters; pathology of major organ systems; and review of diagnostic tools from invasive surgical pathology to non-invasive techniques such as optical spectroscopy, functional imaging, and molecular markers of disease. The objectives of this subject are achieved by a set of integrated lectures and laboratories, as well as a student-driven term project leading to a formal presentation on a medical, socioeconomic, or technological issue in human pathology.

Subject:
Anatomy/Physiology
Biology
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Badizadegan, Kamran
Speech Communication, Spring 2004
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Survey of structural properties of natural languages, with special emphasis on the ...

Survey of structural properties of natural languages, with special emphasis on the sound pattern. Representation of the lexicon. Physiology of speech production, articulatory phonetics. Acoustical theory of speech production; acoustical and articulatory descriptions of phonetic features and of prosodic aspects of speech. Perception of speech. Models of lexical access and of speech production and planning. Applications to recognition and generation of speech by machine, and to the study of speech disorders.

Subject:
Computer Science
Linguistics
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Stevens, Kenneth
Principles and Practice of Tissue Engineering, Fall 2004
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The principles and practice of tissue engineering (and regenerative medicine) are taught ...

The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology (HST) and Tsinghua University, Beijing, China. The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions (e.g., static versus dynamic). Methods for fabricating tissue-engineered products and devices for implantation are taught. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies.

Subject:
Environmental Science
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Cui, Fu-Zhai
Spector, Myron
Quantitative Physiology: Cells and Tissues, Fall 2004
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Principles of mass transport and electrical signal generation for biological membranes, cells, ...

Principles of mass transport and electrical signal generation for biological membranes, cells, and tissues. Mass transport through membranes: diffusion, osmosis, chemically mediated, and active transport. Electric properties of cells: ion transport; equilibrium, resting, and action potentials. Kinetic and molecular properties of single voltage-gated ion channels. Laboratory and computer exercises illustrate the concepts. For juniors and seniors. Students engage in extensive written and oral communication exercises.

Subject:
Computer Science
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Freeman, Dennis
Physiology of the Ear, Fall 2004
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Physical and physiological mechanisms underlying the transduction and analysis of acoustic signals ...

Physical and physiological mechanisms underlying the transduction and analysis of acoustic signals in the auditory periphery. Topics include the acoustics, mechanics, and hydrodynamics of sound transmission; the biophysical basis for cochlear amplification; the physiology of hair-cell transduction and synaptic transmission; efferent feedback control; the analysis and coding of simple and complex sounds by the inner ear; and the physiological bases for hearing disorders. Based primarily on reading and discussions of original research literature. Topics for this course are based primarily on reading and discussions of original research literature that cover the analysis as well as the underlying physical and physiological mechanisms of acoustic signals in the auditory periphery. Topics include the acoustics, mechanics, and hydrodynamics of sound transmission; the biophysical basis for cochlear amplification; the physiology of hair-cell transduction and synaptic transmission; efferent feedback control; the analysis and coding of simple and complex sounds by the inner ear; and the physiological bases for hearing disorders.

Subject:
Anatomy/Physiology
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Guinan, John, Jr.
Genomic Medicine, Spring 2004
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This course reviews the key genomic technologies and computational approaches that are ...

This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely encounter from patients? how should s/he respond? Lecturers will guide the student through real world patient-doctor interactions. Outcome considerations and socioeconomic implications of personalized medicine are also discussed. The first part of the course introduces key basic concepts of molecular biology, computational biology, and genomics. Continuing in the informatics applications portion of the course, lecturers begin each lecture block with a scenario, in order to set the stage and engage the student by showing: why is this important to know? how will the information presented be brought to bear on medical practice? The final section presents the ethical, legal, and social issues surrounding genomic medicine. A vision of how genomic medicine relates to preventative care and public health is presented in a discussion forum with the students where the following questions are explored: what is your level of preparedness now? what challenges must be met by the healthcare industry to get to where it needs to be?

Subject:
Health, Medicine and Nursing
Genetics
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Kohane, Isaac
Medical Decision Support, Fall 2005
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Presents the main concepts of decision analysis, artificial intelligence, and predictive model ...

Presents the main concepts of decision analysis, artificial intelligence, and predictive model construction and evaluation in the specific context of medical applications. Emphasizes the advantages and disadvantages of using these methods in real-world systems and provides hands-on experience. Technical focus on decision analysis, knowledge-based systems (qualitative and quantitative), learning systems (including logistic regression, classification trees, neural networks), and techniques to evaluate the performance of such systems. Students produce a final project using the methods learned in the subject, based on actual clinical data. (Required for students in the Master's Program in Medical Informatics, but open to other graduate students and advanced undergraduates.)

Subject:
Computer Science
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Human Reproductive Biology, Fall 2005
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Lectures and clinical case discussions designed to provide the student with a ...

Lectures and clinical case discussions designed to provide the student with a clear understanding of the physiology, endocrinology, and pathology of human reproduction. Emphasis is on the role of technology in reproductive science. Suggestions for future research contributions in the field are probed. Students become involved in the wider aspects of reproduction, such as prenatal diagnosis, in vitro fertilization, abortion, menopause, contraception and ethics relation to reproductive science. This course is designed to give the student a clear understanding of the pathophysiology of the menstrual cycle, fertilization, implantation, ovum growth development, differentiation and associated abnormalities. Disorders of fetal development including the principles of teratology and the mechanism of normal and abnormal parturition will be covered as well as the pathophysiology of the breast and disorders of lactation. Fetal asphyxia and its consequences will be reviewed with emphasis on the technology currently available for its detection. In addition the conclusion of the reproductive cycle, menopause, and the use of hormonal replacement will be covered.

Subject:
Anatomy/Physiology
Biology
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Henry
Klapholz
Quantitative Genomics, Fall 2005
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Subject assesses the relationships between sequence, structure, and function in complex biological ...

Subject assesses the relationships between sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive functional-genomics analyses. Topics include: algorithmic, statistical, database, and simulation approaches; and practical applications to biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations critically assessed. Problem sets and project emphasize creative, hands-on analyses using these concepts.

Subject:
Biology
Genetics
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Berwick, Robert
Kho, Alvin
Kohane, Isaac
Mirny, Leonid
Principles of Pharmacology, Spring 2005
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An introduction to pharmacology. Topics include mechanisms of drug action, dose-response relations, ...

An introduction to pharmacology. Topics include mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interactions, and substance abuse. Selected agents and classes of agents examined in detail.

Subject:
Chemistry
Physics
Material Type:
Full Course
Textbook
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare