This project will recommend a big data analytics tool for the customers, …
This project will recommend a big data analytics tool for the customers, ministry and hotels in Oman to adapt new hotel services after considering together hotel services with customer opinions. The IOT services are for customer convenience, control in online booking IOT services such as radio station, smart coffee makers, dim lights and energy programmed lights.The big data analytics will analyze the hotel information , rating and reviews of UK , Dubai to recomend aspect like services especially IOT services. The coverage of Analysis in R: Big data Analytics with Hadoop/HDFS Sentiment AnalysisEmotion Analysis Machine Learning K-mean , Regression and Neural NetworkAnova version to analyze Big data of 90k reviews
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"The MAPK/ERK inhibitor vemurafenib is frequently used to treat late-stage melanomas with the BRAF V600E mutation, but acquired resistance is a major challenge, and it’s unclear if this resistance is due to unintended effects on normal stromal cells. To find out, a recent study examined early vemurafenib-induced molecular changes in human dermal fibroblasts (HDFs), a main stromal cell type of melanomas. Sequencing revealed that vemurafenib upregulated proliferation-related genes but downregulated genes related to autophagy and protein degradation in the HDFs, while it exerted the opposite effects in melanoma (MaMel) cells. The expression changes were consistent with the observed paradoxical effects of vemurafenib. Specifically, vemurafenib hyperactivated MAPK/ERK signaling in normal HDFs despite inhibiting it in melanoma cells, which seemed to be facilitated by a permissive chromatin landscape. The paradoxical effects indicate that vemurafenib monotherapy may promote cancer progression in normal cells..."
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