Search Results (1)

Save

Please log in to save materials.

View
Selected filters:
  • Fibrils
Protein Folding, Misfolding and Human Disease, Fall 2004
Conditions of Use:
Remix and Share
Rating

Seminar covering topics of current interest in biology. Includes reading and analysis ... More

Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. The instructor for this course, Dr. Kosinski-Collins, is a member of the HHMI Education Group. Maintenance of the complex three-dimensional structure adopted by a protein in the cell is vital for function. Oftentimes, as a consequence of environmental stress, genetic mutation, and/or infection, the folded structure of a protein gets altered and multiple proteins stick and fall out of solution in a process known as aggregation. In many protein aggregation diseases, incorrectly folded proteins self-associate, forming fiber-like aggregates that cause brain cell death and dementia. In this course, the molecular and biochemical basis of the prion diseases, which include bovine spongiform encephalopathy (mad cow disease), Creutzfedt-Jakob disease and kuru will be examined. Also discussed are other classes of misfolding diseases such as Alzheimer's disease and Huntington's disease. The proteins involved in all of these disorders and how the proteins' three dimensional structures change during the course of these afflictions is covered as well as why prions from certain species cannot infect animals from other species based on protein sequence and structure. The course will then address possible detection methods and therapies that are under development to treat some of the protein aggregation diseases. Less

More
Subject:
Biology
Material Type:
Full Course
Homework and Assignments
Syllabi
Provider:
M.I.T.
Provider Set:
MIT OpenCourseWare
Author:
Kosinski-Collins, Melissa
Less
2002 gnirpS ,ngiseD gnireenignE liviC ot noitcudortnI
Rating

.)310.1( tcejbus ngised enotspac eht dna )150.1 ,140.1 ,130.1( stcejbus ngised aera ... More

.)310.1( tcejbus ngised enotspac eht dna )150.1 ,140.1 ,130.1( stcejbus ngised aera ytlaiceps tneuqesbus eht ni desu si hcihw decudortni si esac ngised egral A .naps efil detcepxe dna ,srotcaf laicos dna cimonoce ,tnemnorivne larutan ,tnemnorivne tliub gnitsixe eht fo noitaredisnoc sa llew sa sehcaorppa lacinhcet snrecnoc ylticilpxe ngised tcejorP .)sdaor dna segdirb ,sgnidliub ,.g.e( seitilicaf tliub no sisahpme na htiw ,sesac ngised lareves sedulcnI .gnireenigne livic ni secitcarp dna seussi ngised sa llew sa ,gnivlos-melborp evitaerc dna ngised gnireenigne fo seuqinhcet dna ,sloot ,yroeht eht ot stneduts secudortnI Less

More
Less